PHY 545: Nanotechnology in Imaging and Therapy
Please note that exact details of the course can vary
Professor: Dr Yana Reshetnyak
Semester: Spring of even-numbered years
Prerequisites :Permission from instructor
Nanomaterials: physical properties, application in drug delivery and diagnostics, nanodevices, nano-oncology.
Course Goals & Outcomes
Upon completion students are expected: to explain the difference in physical properties between macro and nano-sized objects; describe application of nano-sized objects in medicine and biology.
Upon completion, successful students will be able to:
The course will overview nanotechnology from physics perspective and introduce cutting-edge nanomedical technologies and their applications in imaging and therapy of pathological states. The course consists of instructor and students presentations prepared under instructor guidance.
This course will include lectures and students presentations.The course will be based on the lectures material, which will be available on-line
Topics covered in this course include:
- Nanotechnology: overview of methods, which allow to get nano-size resolution. Nanomaterials. Cancer and nanotechnology. Concept of theronostics
- Cellular uptake of nanocarriers. Endocytosis. Fusion.
- Lipid-based delivery nanocarriers.
- Viral vectors. VLP. Gene Therapy.
- Polymeric nanocarriers and dendrimers
- Peptide delivery agents: pHLIP
- Fullerens. Carbon nanotubes: physical properties and delivery agents
- Transfer from bulk to nano-sized materials: physical properties. Quantum dots. Quantum Confinement.
- Gold and magnetic nanoparticles. Hypothermia. Surface Plasmon
- Peptide nanotubes and various structures. Aptamers
- Targeting approaches. Biomarkers. Targeting of microenvironment. Toxicity of nanomaterials.
- Biosensors. SPR. Micro and nano-fabrications techniques.
Contact Information: Dr Yana Reshetnyak
LEC: (3 crs.) Nanomaterials: physical properties, application in drug delivery and diagnostics, nanodevices, nano-oncology. (Lec. 3) Pre: MTH 244.