Brian Plouffe

  • Clinical Assistant Professor
  • Email:
  • Office Location: Woodward Hall, Rm 239


Dr. Brian Plouffe is a Clinical Assistant Professor in the Department of Cell and Molecular Biology. He is the academic advisor for the Biotechnology program within the department. He obtained his Ph.D in Chemical Engineering from Northeastern University with a focus on diagnostic and therapeutic applications of nanomedicine platforms. After Northeastern, Dr. Plouffe was a Postdoctoral Research Associate at MIT. In 2013, Dr. Plouffe co-founded a biotechnology company, Quad Technologies, that was subsequently acquired by Bio-Techne (NASDAQ: TECH) in July 2018. Before joining URI, he also founded the Biomedical Engineering program at Regis College in Weston, MA, serving as the program director from 2016-2021.


  • Ph.D. Chemical Engineering, Northeastern University, 2011
  • M.S. Chemical Engineering, Northeastern University, 2007
  • B.S. Chemical Engineering, University of Rhode Island, 2004

Selected Publications

F. Diekmann, P. Chouvarine, H. Sallmon, L. Meyer-Kobbe, M. Kieslich, B.D. Plouffe, S.K. Murthy, R. Lichtinghagen, E. Legchenko, G. Hansmann. “Soluble Receptor for Advanced Glycation Endproducts (sRAGE) is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension” International Journal of Molecular Science 22: 8591 (2021)

S.A. Mensah, M.J. Cheng, H. Homayoni, B.D. Plouffe, A.J. Coury, and E.E. Ebong. “Regeneration of Glycocalyx by Heparan Sulfate and Sphingosine 1-Phosphate Restores Inter-Endothelial Communication” PLoS One 12: e0186116 (2017)

B.D. Plouffe and S.K. Murthy. “Fluorescence-based Lateral Flow Assays for Rapid Oral Fluid Roadside Detection of Cannabis Use” Electrophoresis 38: 501-506 (2017)

L. Calvier, E. Legchenko, L. Grimm, H. Sallmon, A. Hatch, B.D. Plouffe, C. Schröder, J. Bauersachs, S.K. Murthy, and G. Hansmann, “Galectin-3, a novel biomarker in patients with pulmonary arterial hypertension” Heart 102: 390–396 (2016)

S. Li, B.D. Plouffe, A.M. Belov, S. Ray, X. Wang, S.K. Murthy, B.L. Karger, and A.R. Ivanov. “An Integrated Platform for Isolation, Processing and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood” Molecular & Cellular Proteomics 14: 1672–1683 (2015)

B.D. Plouffe, S.K. Murthy, and L.H. Lewis. “Fundamentals and Application of Magnetic Particles in Biological Cell Separation” Reports on Progress in Physics 78: 016601 (2015)

B.D. Plouffe and S.K. Murthy. “Perspective on Microfluidic Cell Separation: A Solved Problem?” Analytical Chemistry 86: 11481–11488 (2014) (Invited Perspectives Article)

B.D. Plouffe, M. Mahalanabis, L.H. Lewis, C.M. Klapperich, and S.K. Murthy. “Clinically Relevant Microfluidic Magnetophoretic Isolation of Rare-Cell Populations for Diagnostic and Therapeutic Monitoring Applications” Analytical Chemistry 84: 1336–1344 (2012)