Research

iCubed conducts basic and translational research into the biology of infectious diseases, host-pathogen interactions, and mechanisms of disease pathogenesis.

Dengue

Dengue is an acute viral illness transmitted by mosquitoes, mainly in tropical regions of the world. Although illness is usually mild, dengue can be life-threatening.

Our research seeks to understand how interactions between the virus and human host determine the severity of the illness.

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Selected publications

Link to all iCubed publications in PubMed

Sanchez-Vargas LA, Mathew A, Salje H, Sousa D, Casale NA, Farmer A, Buddhari D, Anderson K, Iamsirithaworn S, Kaewhiran S, Friberg H, Currier JR, Rothman AL. Protective Role of NS1-Specific Antibodies in the Immune Response to Dengue Virus through Antibody-Dependent Cellular Cytotoxicity. J Infect Dis. 2024 Mar 13;. doi: 10.1093/infdis/jiae137. [Epub ahead of print] PubMed PMID: 38478732.

Udawatte DJ, Lang DM, Currier JR, Medin CL, Rothman AL. Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1. Front Cell Infect Microbiol. 2022;12:926036. doi: 10.3389/fcimb.2022.926036. eCollection 2022. PubMed PMID: 36310878; PubMed Central PMCID: PMC9615918.

Sanchez Vargas LA, Adam A, Masterson M, Smith M, Lyski ZL, Dowd KA, Pierson TC, Messer WB, Currier JR, Mathew A. Non-structural protein 1-specific antibodies directed against Zika virus in humans mediate antibody-dependent cellular cytotoxicity. Immunology. 2021 Oct;164(2):386-397. doi: 10.1111/imm.13380. Epub 2021 Jun 14. PubMed PMID: 34056709; PubMed Central PMCID: PMC8442231.

Udawatte DJ, Rothman AL. Viral Suppression of RIPK1-Mediated Signaling. mBio. 2021 Aug 31;12(4):e0172321. doi: 10.1128/mBio.01723-21. Epub 2021 Aug 10. Review. PubMed PMID: 34372694; PubMed Central PMCID: PMC8406217.