Our research group employs techniques in nanotechnology, engineering, and pharmaceutics to develop novel formulations capable of penetrating biological barriers associated with pulmonary diseases. We use principles in biomimetics, particle engineering, inhaler science, and pharmaceutical manufacturing to produce results relevant to large-scale manufacturing of novel inhalable therapeutics. Common research themes include investigating the potential of acetalated dextran as a promising polymer for drug release, as well as the optimization of spray drying parameters for the fabrication of dry powders.
Current Projects
Spray dried flavonoid-loaded nanocomposite microparticles (nCmP)
Flavonoids are a class of poorly water-soluble compounds that have been shown to have major therapeutic effects on inflammatory pulmonary diseases. Nanocomposite microparticles (nCmP) is a drug delivery platform that combines the benefits of nano- and microparticles into one system for efficient delivery of drugs to the deep lung. We are currently investigating ways in which to successfully encapsulate and aerosolize spray-dried flavonoid nCmP to overcome the challenges associated with the delivery of poorly water-soluble drugs.
Novel drug-loaded smart bandages for drug delivery
In collaboration with the Roxbury Lab, we are using electrospinning to develop a drug-loaded smart bandage capable of delivering wound healing agents triggered by the presence of infection biomarkers in wounds.
Platelet membrane-coated nanoparticles for the treatment of pulmonary fibrosis
Platelet membranes have been shown to preferentially bind to scar tissue and attenuate collagen production – two symptoms that characterize pulmonary fibrosis. We are investigating the potential for platelet membranes to be used as coatings for drug-loaded nanoparticles to treat pulmonary fibrosis.