Nervous System Wiring by the RoBo3 Axon Guidance Receptor and its Ligand NELL2

Investigator: Alexander Jaworski, Brown University Scientific Theme: Neuroscience Abstract: Guidance of axons to their targets is central to nervous system wiring, but the mechanisms of axon guidance are not completely understood. The proposed work aims to elucidate the function of a new axon guidance cue, NELL2, and its receptor Robo3 in neurodevelopment and to define molecular mechanisms […]

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Studying Cortico-Muscular Coherence: Fusing Neuroimaging with Body Motion

Investigator: Kunai Mankodiya, University of Rhode Island Scientific Theme: Neuroscience Abstract: The proposal aims at establishing an innovative framework to integrate a wearable full-body motion capture suit with a portable neuroimaging based on functional near-infrared spectroscopy (fNIRS). The unified infrastructure will quantify cortico-muscular coherence (CMC) in people with movement disorders. Cortico-muscular coherence (CMC) also known […]

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Mechanisms of Treprostinil-Mediated Anti-Inflammation in Liver Diseases

Investigator: Nisanne Ghonem, University of Rhode Island Scientific Theme: Cancer & Molecular Toxicology Abstract: Orthotopic liver transplantation (OLT) is the only curative therapy for end-stage liver diseases. The surgical procedure inherently involves cold ischemia during graft preservation, followed by graft reperfusion, resulting in cold ischemia and reperfusion (I/R) injury. I/R injury is a major cause of liver […]

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