The National Institutes of Health (NIH) Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability (STRIDES) Initiative is designed to enhance biomedical discovery and improve efficiency through new digital data management strategies that contribute to NIH efforts to develop and sustain a modern biomedical data ecosystem. In partnership with cloud service providers, like Amazon Web Services (AWS), STRIDES provides a cost-effective way for biomedical researchers at the NIH and at NIH-funded institutions to access rich datasets and the most advanced computational infrastructure, tools, and services.