Instrumentation Update
The CRCF purchased two new instruments: the NanoTemper Monolith X and the BioTek Synergy H1 Multimode Reader. To accommodate the demands and needs of researchers statewide, the CRCF applied for the National Institutes of Health (NIH) supplemental funds PA-20-272 grant to acquire the NanoTemper Monolith X
instrument. The NanoTemper Monolith X, a fluorescence-based detection system, accurately assesses biomolecular interactions using MicroScale Thermophoresis (MST). The Monolith X complements the CRCF’s existing Surface Plasmon Resonance (SPR) technology by combining isothermal spectral shift measurement with MST technology, further enhancing the CRCF capabilities in molecular interaction analysis.
In January 2024, the BioTek Synergy H1 replaced the CRCF’s existing SpectraMax readers. The BioTek Synergy H1 Multimode Reader, a cutting-edge modular multimode microplate reader, is capable of performing absorbance, fluorescence, and luminescence readings. This state-of-the-art instrument is a valuable asset for supporting all research and academic pursuits at URI, all nine participating RI-INBRE research institutions, and RI’s biomedical research community.