Division of Research and Economic Development

Expanding the University's research enterprise.

Comparative Biology Resources Center

The Comparative Biology Resources Program (CBRC) provides URI faculty, staff, and students high-quality husbandry and support services to accomplish our shared research objectives. We provide housing facilities, husbandry services, veterinary support, and personnel training to support the University’s research and teaching goals. All vivaria and support areas assure humane care through compliance with Federal regulations and University policies.

  • Investigators will be charged per diem on acquisitions housed and cared for by the CBRC. All fees and additional services provided in the previous month will be included on the invoice.

    Within 10 days of the new month, investigators will be sent by email attachment the prior month’s invoice. Investigators are required to review all charges for accuracy and submit a valid Chart Field String (CFS) to CBRC at email CBRC@uri.edu to cover the invoiced charges. During the 3rd week of the month, internal vouchers will be submitted to accounting to move money from each investigator account previously identified by CFS. Those accounts identified by accounting with either invalid CFS, or inadequate funds will be sent back to the investigator correct the issue.

    We encourage investigators to use blanket POs to generate valid CFS’s to cover 6 to 12 months of care charges. Each investigator should estimate monthly care charges (for assistance contact Dr. Brackee at gbrackee@uri.edu) and generate the blanket PO with enough to cover this extended time period. Funds will only be removed from accounts when a monthly statement has been processed by the CBRC.

  • Acquisitions from either CBRC-approved vendors or  imports.

    All purchases and acquisition for use must be processed by the CBRC at CBRC@uri.edu. Likewise, all imports must be coordinated through the LARC office, and approved by the Attending Veterinarian prior to shipment.

    We have created the CBRC-Approved Vendors page and the Imports (non-standard) page to help investigators coordinate with the CBRC for research acquisitions for IACUC-approved studies.

  • The CBRC maintains database information, literature, and case reports pertaining to these topics. Best practices and guideline documents have been prepared to assist investigators with these procedures. Contact the Attending Veterinarian and CBRC staff at email CBRC@uri.edu for this information.

    • Guidelines for Blood Collection
    • Pain Guidelines
    • Guidelines for Dosing
    • Use of Non-Pharmaceutical Compounds
    • Testing of Cell Lines and other Biologics Prior to use 
    • Suggestions for Maintaining Appropriate Medical Records
    • Anesthetic Gas Scavenging
    • Use of Respiratory Protection and other PPE
    • Writing a Good Layman’s Summary
    • Determination of the Number of Acquisitions Needed in Each Study Group
    • Searching the Literature using the Three R’s
    • Best Practices when Prolonged Restraint is Necessary
    • Immunization and Antibody Production including Ascites Production
  • The following are per diem (by the day) charges. This cost is for general maintenance and operation for daily care.

    For grant writing purposes, assume an annual increase of 3% on these charges. 

    For additional species and/or general information, contact the Attending Veterinarian at email CBRC@uri.edu.

  • The Comparative Biology Resources Center (CBRC) has developed an SOP manual that describes the procedures in use for normal CBRC activities. Investigators and staff are encouraged to review the specific SOPs needed for their activities within the vivarium. Knowledge of these procedures is important prior to beginning work at any of the facilities.

    The SOP manual is a very valuable tool. It is used to provide training to new staff, to answer specific questions regarding procedures and/or equipment, to demonstrate to inspectors and accreditation site visitors our conduct of the care program, and to catalog procedures for future reference.

    SOP Numbering System: The General sections are assigned a three digit number commencing with 100 and proceeding numerically in multiples of 100 until all general categories are addressed. Individual SOP’s are assigned a unique number followed by a decimal point and two additional digits to indicate the revision number.

    100’s  General Operating Procedures

    200’s  Room Maintenance

    300’s  Daily Health

    400’s  Operations

    500’s  Veterinary Procedures

    600’s  Occupational Health, Hazards, and Safety

    700’s  Quality Assurance and Microbiological Surveillance

    800’s  Enrichment

    900’s  ABSL Practices

  • 1. Make application to the Rhode Island Department of Health.

    a. Fill out Controlled Substances application at:

    i. At top of form, mark “new application”

    ii. for Registration classification mark item “D. Researcher”

    iii. for drug schedule mark “2,3,4,5”

    iv. mark DEA number as “pending”

    v. email completed application to mariane.soto@health.ri.gov

    b. Mariane will send you the “Tax Payer Status Affidavit” for you to sign and return.

    c. Send Mariane check, pcard, or credit card for $100. fee.

    d. Once RI DOH has issued your controlled substance registration, make application to the


    2. Make application to Federal DEA

    a. Fill out application at Federal DEA website: 

    b. Select “New Applications Online”

    c. Select DEA form 225 “Researchers”

    d. Select Business Activity as “Researcher (II-V)”

    e. Click “Begin” at bottom of page.

    f. Remember to select govt agency so the fee is waived.


    3. Federal DEA will contact you by email to acknowledge the receipt of your application.


    4. Next, they will require completion of researcher questionnaire sent to you by email. As an example, see my completed questionnaire attached.


    5. My contact at the Federal DEA was:

    Barbara Menhart, Registration Program Specialist
    Drug Enforcement Administration
    New England Field Division
    Boston Diversion Group
    Office # 617-557-2200
    Fax # 617-557-2126
    E-mail: Barbara.Menhart@usdoj.gov


    6. She is very helpful and pleasant on the phone and email communication.


    7. Once you have obtained the DEA registration certificate, scan and email to Rhode Island (mariane.soto@health.ri.gov) to complete your application with RI Dept of Health.

  • As of February 2015, the LASC is operating under a new vendor name. Please make all POs for the LASC to “URI_LAC”. Please make this change when submitting to increase funds or when you’re extending your current PO for the new fiscal year.

    The Laboratory Animal Service Center (LASC) facilitates the humane care and use of laboratory animals (e.g., mice, rats, hamsters, guinea pigs and rabbits) in research and teaching at the University of Rhode Island.

    The LASC is operated by the Comparative Biology Resources Center, 75 Lower College Road. This office places all animal orders; maintains inventories of food, bedding, sanitation materials, and clinical supplies; and processes animal care billing to principal investigators. Please call the main office line (401)874-2408 or email gbrackee@uri.edu for further information.

    Policies and Procedures

    Laboratory Animal Service Center SOP

    Submitting a PO

    Animal Users Health and Safety Program

    Rates and Fees

    The LASC is required to recover the costs associated with the care of laboratory animals through per diem rates. Per diem rates are based on the cost analysis and recovery procedures delineated in the National Institutes of Health (NIH) Cost Analysis and Rate Setting Manual for Animal Research Facilities. Approximately 80% of animal care costs are subsidized by the Division of Research and Economic Development and the individual Colleges. Please contact the Comparative Biology Resources Center gbrakee@uri.edu (401)874-2408 for specific rate information. 

    Invoices are processed monthly and charged interdepartmentally to the principal investigator’s Office of Sponsored Projects (OSP) project or department chartfield as located on the animal cage card and room census sheet.

    Program Activities

    The regular program activities of the LASC Center are to make available the following services to all academic and/or research faculty and staff affiliated with the IACUC and animal use:

    • LASC provides complete animal care for all laboratory animals used for research and/or teaching purposes.
    • LASC orders (as requested by Investigators), receives and places into appropriate housing all laboratory animals used for research and/or teaching purposes.
    • LASC provides complete clinical health care and/or diagnostic services for all laboratory animals under our charge.
    • LASC provides consultation (as requested by investigators) on veterinary, regulatory, and/or animal model aspects of laboratory animal use.
    • LASC distributes to all interested academic and/or research faculty and staff any current, relevant information of a general nature regarding the proper use of laboratory species.
    • LASC distributes specific information to principal investigators regarding current innovations in the area of their individual research interests.
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