Daniel Roxbury


  • Nanoscience
  • Carbon Nanotubes
  • Nanomaterials
  • Carbon Nanomaterials
  • Thin Films and Nanotechnology
  • Bio-analytical Sensors
  • Nano Spectroscopy
  • Molecular Dynamics Simulation


  • Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, 2012-2016
  • Ph.D., Chemical Engineering, Lehigh University, 2012
  • B.S., Chemical Engineering, Lehigh University, 2007

Selected Publications

Nadeem A, Kindopp A, Wyllie I, et al.Enhancing Intracellular Optical Performance and Stability of Engineered Nanomaterials via Aqueous Two-Phase Purification. Nano Letters, 2023; 23(14), 6588-6595 doi: 10.1021/acs.nanolett.3c01727
Roger LM, Lewinski NA, Putman HM, Roxbury D, Tresguerres M, Wangpraseurt D. Nanobiotech engineering for future coral reefs. One Earth, 2023. doi: 10.1016/j.oneear.2023.05.008
Roger L, Lewinski N, Putnam H, et al. Nanotechnology for coral reef conservation , restoration and rehabilitation. Nature Nanotechnology, 2023. 1-3. doi:  10.1038/s41565-023-01402-6
Card M, Alejandro R, Roxbury D. Decoupling Individual Optical Nanosensor Responses Using a Spin-Coated Hydrogel Platform. ACS Applied Materials & Interfaces, 2022. doi: 10.1021/acsami.2c16596
Gravely M, Kindopp A, Hubert L, et al. Aggregation Reduces Subcellular Localization and Cytotoxicity of Single-Walled Carbon Nanotubes. ACS Applied Materials & Interfaces, 2022. doi: 10.1021/acsami.2c02238
Jena PV, Gravely M, Cupo C, Safaee MM, Roxbury D, Heller DA. Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles. ACS Nano, 2022. doi: 10.1021/acsnano.1c10708
Langenbacher R, Budhathoki-Uprety J, Jena PV, et al. Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes. Nano Letters, 2021. doi: 10.1021/acs.nanolett.1c01093
Card M, Gravely M, Madani SZM, Roxbury D. A Spin-Coated Hydrogel Platform Enables Accurate Investigation of Immobilized Individual Single-Walled Carbon Nanotubes. ACS Applied Materials & Interfaces, 2021; 13(27), 31986-31995. doi: 10.1021/acsami.1c06562
Gravely M, Roxbury D. Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells. ACS Nano, 2021. doi: 10.1021/acsnano.1c04500
Safaee MM., Gravely M., Roxbury D. A Wearable Optical Microfibrous biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress. Advanced Functional Materials, 2021; 2006254. doi: 10.1002/adfm.202006254
Madani SZM, Safaee MM., Gravely M., et al. Carbon Nanotube-Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation. ACS Applied Nano Materials, 2021; 4(11), 331-342. doi: 10.1021/acsanm.0c02700
Heller DA, Jena PV, Pasquali M, et al. Banning carbon nanotubes would be scientifically unjustified and damaging to innovation. Nature Nanotechnology, 2020; 15(3), 164-166. doi: 10.1038/s41565-020-0656-y
Madani SZM, Reisch A, Roxbury D, Kennedy SM. A Magnetically Responsive Hydrogel System for Controlling the Timing of Bone Progenitor Recruitment and Differentiation Factor Deliveries. ACS Biomaterials Science & Engineering, 2020; 6(3), 1522-1534. doi: 10.1021/acsbiomaterials.9b01746
Horoszko CP, Jena PV, Roxbury D, Rotkin SV, Heller Heller DA. Optical Voltammetry of Polymer-Encapsulated Single-Walled Carbon Nanotubes. Journal of Physical Chemistry C, 2019; 123(39), 24200-24208. doi: 10.1021/acs.jpcc.9b07626
Gravely M, Safaee MM, Roxbury D. Biomolecular Functionalization of a Nanomaterial to Control Stability and Retention Within Live Cells. Nano Letters, 2019; 19(9), 6203-6212. doi: 10.1021/acs.nanolett.9b02267
Safaee MM, Gravely M, Lamothe A, McSweeney M, Roxbury D. Enhancing the Thermal Stability of Carbon Nanomaterials with DNA. Scientific Reports, 2019; 9, 11926. doi: 10.1038/s41598-019-48449-x
Safaee MM, Gravely M, Rocchio C, Simmeth M, Roxbury D. DNA Sequence Mediates Apparent Length Distribution in Single-Walled Carbon Nanotubes. ACS Applied Materials & Interfaces, 2019; 11(2), 2225-2233. doi: 10.1021/acsami.8b16478
Galassi TV, Jena PV, Shah J, et al. An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo. American Association for the Advancement of Science, 2018; 10(461), eaar2680. doi: 1126/scitranslmed.aar2680
Shamay Y, Shah J, Isik M, et al. Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines. Nature Materials, 2018; 17(4), 361-368. doi: 10.1038/s41563-017-0007-z

Recent Grants

8/2/2023. PI. National Science Foundation. “CAREER: Spectral Imaging for Sub-Cellular Nanometrology and Nanotoxicology”
2/14/2023. PI. The Miriam Hospital “COBRE: Wearable smart textiles for non-invasive detection of the stress biomarker cortisol.”
7/1/2022. PI. National Science Foundation. “EAGER: Multiplexed Wound Biomarker Detection with a Nanosensor Embedded Microfibrous Biomaterial.”
7/1/2022. PI. National Science Foundation. “EAGER: Multiplexed Wound Biomarker Detection with a Nanosensor Embedded Microfibrous Biomaterial.”
7/2/2019. PI. National Science Foundation. "CAREER: Spectral Imaging for Cellular Nanometrology and Nanotoxicology."
9/10/2018. Co-PI. National Science Foundation. “MRI: Acquisition of a Confocal High Content Screening System to Enhance Bioengineering, and Biomedical Research.”

Honors & Awards

  • 2019 NSF CAREER Award

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