INVESTIGATORS: Geoff Stilwell, Rhode Island College THEME: Neuroscience ABSTRACT: Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motor neuron (MN) degeneration, muscle weakness and death within 3-5 after diagnosis. Mutations in superoxide dismutase 1 (sod1) cause ALS and approximately 170 different mutations in this gene have been documented in patients to date. Irrespective of which […]
Continue reading "Detecting SOD1 Aggregates In A Drosophila Model Of Amyotrophic Lateral Scelerosis"Category: SURF PUI Award-2019
SURF PUI Training and Development Awards 2019
Nano-Biomarker Arrays for Cutaneous T-Cell Carcinoma
INVESTIGATOR: Bernard Munge, Salve Regina University THEME: Environmental Health Sciences ABSTRACT: Rapid, extremely sensitive and accurate biosensor arrays for clinical measurements of biomarker proteins for early detection and monitoring of cancer are critically important and will lead to inexpensive devices for reliable on-the-spot cancer diagnosis, improved therapeutic outcomes at lower costs, decreased patient stress, and […]
Continue reading "Nano-Biomarker Arrays for Cutaneous T-Cell Carcinoma"Exploring the Inhibition of Quorum Sensing-Controlled Biofilm Formation
INVESTIGATOR: Susan Meschwitz, Salve Regina University THEME: Environmental Health Sciences ABSTRACT: Traditional therapeutics to treat bacterial infections have given rise to multi-drug resistant pathogens, which pose a major threat to human and environmental health. Many bacteria found in the environment and in chronic infections exist in highly structured multi-cellular communities known as biofilms, and the […]
Continue reading "Exploring the Inhibition of Quorum Sensing-Controlled Biofilm Formation"Exploring the Relationship Between Structure and Function in KmtR
INVESTIGATOR: Khadine Higgins, Salve Regina University THEME: Environmental Health Sciences ABSTRACT: The long term goal of this work is aimed at understanding why Mycobaterium tuberculosis (M. tuberculosis) requires two Ni(II)- and Co(II)-responsive metalloregulators associated with the export of Ni(II) and Co(II) and how these two regulators differ. M. tuberculosis is the causative agent of tuberculosis, […]
Continue reading "Exploring the Relationship Between Structure and Function in KmtR"Neuroscience: Negative Experiences and Late Adolescents Health Outcomes
INVESTIGATOR: Emily Cook, Rhode Island College THEME: Neuroscience ABSTRACT: Past research during adulthood has suggested that how individuals handle stress emotionally and physically has implications for behavioral and physical health during adolescence. Yet we know little about daily stressors (i.e., minor yet frequent stressful experiences such as daily tests, family arguments) among late adolescents (the […]
Continue reading "Neuroscience: Negative Experiences and Late Adolescents Health Outcomes"Neuroscience: Disrupting Toxic Protein Aggregates in a Yeast Model of Parkinson’s Disease
INVESTIGATOR: Nicanor Austriaco, Providence College THEME: Neuroscience ABSTRACT: Parkinson’s Disease (PD) is a neurodegenerative disorder that leads to progressive deterioration of motor function due to the loss of dopamine-producing cells in the brain. The pathological hallmark of PD is the abnormal aggregation of specific proteins, including, most significantly, α-synuclein, which is an abundant, presynaptic protein of […]
Continue reading "Neuroscience: Disrupting Toxic Protein Aggregates in a Yeast Model of Parkinson’s Disease"