Investigator: Yingsheng Wan, Providence College Scientific Theme: Cancer Abstract: Our previous studies have demonstrated that ultraviolet radiation (UV) induces skin cell damage leading to skin photo-aging and skin cancer. While the cellular and molecular mechanisms are still to be fully elucidated, the leading causes of skin photo-aging and cancer are the accumulation of reactive oxygen species and the […]
Continue reading "Oxygen generating biomaterials to attenuate UV-induced skin cell damage"Category: Research
DNA Polymerase Theta and its Potential Role in Cancer
Investigator: Jamie Towle-Weicksel, Rhode Island College Mentor: Sarah Delaney, Brown University Scientific Theme: Cancer Abstract: DNA is randomly damaged on a daily basis by many factors including environmental exposure and random replicative errors. This damaged DNA can lead to genomic instability and eventually cancer. The cell copes with this damage through DNA repair pathways and this proposed study focuses […]
Continue reading "DNA Polymerase Theta and its Potential Role in Cancer"Functional differentiation of the rat posterior parietal cortex
Investigator: Victoria Templer, Providence College Mentor: Rebecca Burwell, Brown Scientific Theme: Neuroscience Abstract: The purpose of this project is to determine the functional contribution of the rat posterior parietal cortex (PPC) to specific forms of information processing and memory. Recent evidence suggests the primate dorsal PPC (dPPC) is involved in top-down attention and may be guiding behavior based […]
Continue reading "Functional differentiation of the rat posterior parietal cortex"Sustained Intravitreal Drug Delivery Platform for the Treatment of Uveal Melanoma
Investigator: Jie Shen, University of Rhode Island Mentor: Edith Mathiowitz, Brown University Scientific Theme: Cancer Abstract: Uveal melanoma (UM) is rare yet the most common and malignant primary intraocular tumor in adults. Due to the lack of effective treatment, the mortality rate of UM has remained high over the past few decades. In order to improve the prognosis and […]
Continue reading "Sustained Intravitreal Drug Delivery Platform for the Treatment of Uveal Melanoma"Characterization of Brain Activity in Patients with Amyotrophic Lateral Sclerosis
Investigator: Yalda Shahriari, University of Rhode Island Mentor: Walter Besio, University of Rhode Island Scientific Theme: Neuroscience Abstract: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that affects muscles and nerves. The average life expectancy of ALS is 2-5 years from the diagnosis. In recent years ALS has been recognized as a multi-system disorder, where not only the […]
Continue reading "Characterization of Brain Activity in Patients with Amyotrophic Lateral Sclerosis"Enhancing the permeability of carbon nanomaterials into tumor spheroid models
Investigator: Daniel Roxbury, University of Rhode Island Scientific Theme: Cancer Abstract: The ability to deliver sufficiently high concentrations of chemotherapeutic drugs into patient tumors remains a significant hurdle for the intravenous treatment of solid cancers. Barriers such as a selective endothelium, extracellular matrix, densely packed cancer cells with tight junctions, and high interstitial fluid pressures prohibit the […]
Continue reading "Enhancing the permeability of carbon nanomaterials into tumor spheroid models"Deciphering Kingella kingae RTX-toxin regulation
Investigator: Matthew Ramsey, University of Rhode Island Mentor: David Nelson, University of Rhode Island Scientific Theme: Molecular Toxicology Abstract: Kingella kingae is an emerging pathogen in pediatric infectious diseases that colonizes the throat (oropharynx) of 3-17% of children ~6-60 months asymptomatically and infrequently disseminates from the oropharynx to cause endocardial (heart) or osteoarticular/ osteomyelitic (joint and bone) infection. […]
Continue reading "Deciphering Kingella kingae RTX-toxin regulation"Nano-Biomarker Arrays for Cutaneous T-Cell Carcinoma
Investigator: Bernard Munge, Salve Regina University Scientific Theme: Cancer Abstract: Rapid, extremely sensitive and accurate biosensor arrays for clinical measurements ofbiomarker proteins for early detection and monitoring of cancer are critically important and will lead to inexpensive devices for reliable on-the-spot cancer diagnosis, improved therapeutic outcomes at lower costs, decreased patient stress, and new targeted therapies. Such devices […]
Continue reading "Nano-Biomarker Arrays for Cutaneous T-Cell Carcinoma"Effects of Social Status & Facial Attractiveness on Recognition Memory for Faces
Investigator: Thomas Malloy, Rhode Island College Scientific Theme: Neuroscience Abstract: Recogniton of another’s face has important implicaitons for social behavior and coordinated action. For example, a physician’s ability to recognize a patient’s face, although treating socres of patients, can affect treatment compliance and patient statisfaction. Two experiments focused on facial and social variables that impact viusal […]
Continue reading "Effects of Social Status & Facial Attractiveness on Recognition Memory for Faces"Phosphonium Tethered Terpyridine Metal Complexes as G4-DNA Binders
Investigator: Chin Hin Leung, Rhode Island College Scientific Theme: Cancer Abstract: Guanine-rich DNA quadruplex (G4-DNA) is a form of DNA generally believed to play a crucial role in telomerase activity and certain gene regulations, and has been studied as a potential target for anti-cancer agents. Transition metal containing complexes with a planar environment around the metal center, such […]
Continue reading "Phosphonium Tethered Terpyridine Metal Complexes as G4-DNA Binders"