RI-INBRE (2004 – 2017)
Pilot Projects
Use of Targeted Nanometer-Size Materials to Increase the Effectiveness of Radiation on Cancer
Investigator: Michael Antosh, University of Rhode Island
Effects of Early Life Stress on Neurobehavioral Development
Investigator: Kevin Bath, Brown University
Discovery of anti-cancer leads from cyanobacteria blooms utilizing an MS/MS-based chemical profiling strategy
Investigator: Matthew Bertin, University of Rhode Island
Role of mutant Swi/Snf complexes and their interactors in regulation of differential gene expression in disease
Investigator: Arnob Dutta, University of Rhode Island
Peroxisome proliferator-activated receptor-alpha (PPARĪ±) as a targeted therapy for treatment of bile acid toxicity in cholestatic liver diseases
Investigator: Nisanne Ghonem, University of Rhode Island
Near infrared sensors for assaying the permeability and resultant chemotherapeutic drug delivery efficacy in tumor spheroid models
Investigator: Daniel Roxbury, University of Rhode Island
Metamaterials-based Near-field Enhanced Biosensing for Early Detection of Lung Cancer
Investigator: Yi Zheng, University of Rhode Island
Mechanisms of Treprostinil-Mediated Anti-Inflammation in Liver Diseases (2015)
Investigator: Nissane Ghonem, University of Rhode Island
Nervous System Wiring by the Robo3 Axon Guidance Receptor and its Ligand Nell2 (2015)
Investigator: Alexander Jaworski, Brown University
Studying Cortico-Muscular Coherence: Fusing Neuroimaging With Body Motion (2015)
Investigator: Kunai Mankodiya, University of Rhode Island
A Mechanistic Dissection of Transcription-Coupled DNA Repair (2014-2015)
Investigator: Alexandra Deaconescu, Brown University
Mentor: Rebecca Page, Brown University
Defining the Role of the Cell Adhesion Molecule TAG-1 in Motor Circuit Formation (2014-2015)
Investigator: Alexander Jaworski, Brown University
Mentor: Diane Lipscombe, Brown University
Biomaterials for Sequenced Biomolecular Delivery in Cancer Immunotherapy (2014-2015)
Investigator: Stephen Kennedy, University of Rhode Island
Mentor: Niall Howlett, University of Rhode Island
Chemical Biology of DNA Repair, Cellular Metabolism, and Cancer (2014-2015)
Investigator: Deyu Li, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island
fNIRS-EEG Neuroimaging for Mapping Cortical Activations in PD Patients (2014-2015)
Investigator: Kunal Mankodiya, University of Rhode Island
Mentors: Walter Besio, University of Rhode Island and Lars Wahlberg, NsGene Inc. and Rhode Island Hospital
Investigations of the Anti-Leukemia Activity of Natural Product Penisimplicissin (2014-2015)
Investigator: Lynnie Trzoss, University of Rhode Island
Mentor: David Rowley, University of Rhode Island
Classification and Functional Characterization of the PP1-Binding Proteins (2014-2015)
Investigator: Ying Zhang, University of Rhode Island
Mentor: Rebecca Page, Brown University
A Quantitative Proteomics Approach to Understanding the Sigma-1 Receptor Signaling Pathways (2008-2009)
Investigator: Carthene Bazemore-Walker, Brown University
Mentor: Wayne Bowen, Brown University
Exploring Nucleocytoplasmic Shuttling of Metabolic Enzymes (2006-2007)
Investigator: Alexander Brodsky, Brown University
Mentor: Stephen L. Helfand, Brown University
Relating Biomembrane Disruption to the Potential Toxicity of Synthetic Inorganic Nanoparticles (2007-2008)
Investigator: Geoffrey Bothun, University of Rhode Island
Mentor: Arijit Bose, University of Rhode Island
Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin (2008-2009)
Investigator: Brenton DeBoef, University of Rhode Island
Mentor: William Euler, University of Rhode Island
Total Synthesis of UCS1025A and Derivatives Thereof for Use as Anti-Telomerase Agents (2005-2006)
Investigator: Brenton DeBoef, University of Rhode Island
Mentor: William Euler, University of Rhode Island
Genetic Properties of DNA Damage Induced by Peroxynitrite (2008-2009)
Investigator: Sarah Delaney, Brown University
Mentor: Anatoly Zhitkovich, Brown University
Mutagenesis and Toxicity of Peroxynitrite-Induced DNA Lesions in Human Cells (2007-2008)
Investigator: Sarah Delaney, Brown University
Mentor: Anatoly Zhitkovich, Brown University
Transcriptional Regulation of Bile Salt Export Pump (2006-2007)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island
Transcriptional Regulation of Bile Salt Export Pump by Endobiotics and Xenobiotics (2005-2006)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island
Toxicological Significance of Bile Export Pump (2004-2005)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island
Mechanisms for Estrogen-Mediated Transrepression of Human Bile Salt Export Pump (2008-2009)
Investigator: Ruitang Deng, University of Rhode Island
Mentor: Bingfang Yan, University of Rhode Island
Dissecting the Gene Regulatory Network for Epidermis (2008-2009)
Investigator: Steven Irvine, University of Rhode Island
Mentor: David Nelson, University of Rhode Island
Dissecting Regulation of Intracellular Vesicle Trafficking in a Tick Salivary Gland Model (2006-2007)
Investigator: Shahid Karim, University of Rhode Island
Mentors: Thomas N. Mather, University of Rhode Island and Gary Wessel, Brown University
Fragile Polymer Backbones for Disease Treatment Materials: Organocatalytic Ring-Opening Polymerization of Thioesters (2013-2014)
Investigator: Matthew Kiesewetter, University of Rhode Island
Mentors: Geoffrey Bothun, University of Rhode Island and Gary Wessel, Brown University
Estrogen Sulfotransferase and Estradiol Homeostasis in Mammary Epithelial Cells (2005-2006)
Investigator: Roberta King, University of Rhode Island
Mentors: Bongsup Cho, University of Rhode Island and Bingfang Yan, University of Rhode Island
Estrogen Sulfotransferase Inhibition and Breast Cancer (2004-2005)
Investigator: Roberta King, University of Rhode Island
Mentors: Bongsup Cho, University of Rhode Island and Bingfang Yan, University of Rhode Island
The Effects of Early Embryonic Exposure to PCBs on the Developing Nervous System (2007-2008)
Investigator: Jill Kreiling, Brown University
Mentor: Surendra Sharma, Brown University
Development of a New Class of Antibiotics (2005-2006)
Investigator: Thilo Lange, Brown University
Mentor: Susan Gerbi, Brown University
The Causes and Consequences of Genomic Change in Parasitic Oomycetes (2010-2011)
Investigator: Christopher Lane, University of Rhode Island
Mentor: David Nelson, University of Rhode Island
Evaluating Alpha Toxin and Biofilm Formation in Staphylococcus aureus Through the Accessory Gene Regulator Operon (agr) (2006-2007)
Investigator: Kerry LaPlante, University of Rhode Island
Mentor: David Rowley, University of Rhode Island
Antimicrobial Agents that Inhibit Alpha-Toxin, Prevent Biofilm Formation in Staphylococcus aureus (2005-2006)
Investigator: Kerry LaPlante, University of Rhode Island
Mentor: David Rowley, University of Rhode Island
Establishing Sub-nuclear Domains of Coordinate Gene Regulation (2010-2011)
Investigator: Erica Larschan, Brown University
Mentor: Stephen Helfand, Brown University
Profile of miRNA Expression Alterations by Endocrine Disrupting Toxicants (2007-2008)
Investigator: Carmen Marsit, Brown University
Mentor: Kim Boekelheide, Brown University
Tumor-Penetrating Acetalated Dextran Nanoparticles Capable of Tandem Delivery of Radiosensitizing Agents for the Treatment of Lung Cancer (2013-2014)
Investigator: Samantha Meenach, University of Rhode Island
Mentor: Arijit Bose, University of Rhode Island
Surface Hsc/OC.10 Confers a Growth and Survival Advantage to Oval Cells, Cholangiocytes and Hepatocellular Carcinomas (2007-2008)
Investigator: David Mills, Rhode Island Hospital
Mentor: Douglas Hixson, Brown University
A Field-Deployable Direct Readout Solution-Based SERS method for the Rapid and Sensitive Detection of Pesticides in Fruits and Vegetables (2008-2009)
Investigator: Radha Narayanan, University of Rhode Island
Mentor: Chris Brown, University of Rhode Island
The Dynamic Cellular Localization of TrpM1 (2008-2009)
Investigator: Elena Oancea, Brown University
Mentor: Julie Kauer, Brown University
The Effects of Environmental Oxidants on HePTP Structure and MAP Kinase Interaction (2007-2008)
Investigator: Rebecca Page, Brown University
Mentor: Kristi Wharton, Brown University
Synthesis of Next-Generation Inhibitors of Botulinum Neurotoxin (2008-2009)
Investigator: Becky Sartini, University of Rhode Island
Mentor: Gary Wessel, Brown University
Anti-Inflamatory Effects of Strawberry Polyphenols via Sub-Cellular Signaling Pathways in COX-2 Expressing Human Colon Cancer Cell Line (HT-29) (2008-2009)
Investigator: Navindra Seeram, University of Rhode Island
Mentor: Clinton Chichester, University of Rhode Island
Design of Anticancer Cytotoxins (2004-2005)
Investigator: Yana K. Reshetnyak, University of Rhode Island
Mentor: Clinton Chichester, University of Rhode Island