Geoffrey D. Bothun

Research

  • Nanotoxicology
  • Nanomedicine
  • Inorganic Membranes
  • Engineered Surfaces
  • Nanobiotechnology
  • Nanoparticles
  • Lipids

Education

  • Postdoctoral Fellow. North Carolina A&T State University, 2006
  • Ph.D., University of Kentucky, 2004
  • M.S., University of Kentucky, 2001
  • B.S., Chemical Engineering, University of Nevada, Reno, 1998
  • B.S., Chemistry, University of Nevada, Reno, 1998

Selected Publications

Anik MI, Pan A, Jakaria MG, Meenach SA, Bothun GD. Protein-Templated Core/Shell Au Nanostructures for Intracellular Reactive Oxygen Species Detection by SERS. ACS Applied Nano Materials, 2022, doi: 10/1021/acsanm.2c02641
Poonia M, Kuster T, Bothun GD. Organic Anion Detection with Functionalized SERS Substrates via Coupled Electrokinetic Preconcentration, Analyte Capture, and Charge Transfer. ACS Applied Materials & Interfaces, 2022. doi: 10.1021/acsami.2c02934
Marques E, Pfohl M, Wei W, et al. Replacement per-and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicology and Applied Pharmacology, 2022; 442, 115991. doi: 10.1016/j.taap.2022.115991
Naumann A, Alesio J, Poonia M, Bothun GD. PFAS fluidize synthetic and bacterial lipid monolayers based on hydrophobicity and lipid charge. Journal of Environmental Chemical Engineering, 2022; 10(2), 107351. doi: 10.1016/j.jece.2022.107351
Tsengam IKM, Omarova M, Kelley EG, et al. Transformation of Lipid Vesicles into Micelles by Adding Nonionic Surfactants: Elucidating the Structural Pathway and the Intermediate Structures. The Journal of Physical Chemistry B, 2022. doi: 10.1021/acs.jpcb. 1c09685
Alesio JL, Slitt A, Bothun GD. Critical insights into the binding of poly-and perfluoroalkyl substances (PFAS) to albumin protein. Chemosphere, 2022; 287, 131979. doi: 10.1016/j.chemosphere.2021.131979
Corcoran LG, Almaraz BAS, Amen KY, et al. Using Microemulsion Phase Behavior as a Predictive Model for Lecithin- Tween 80 Marine Oil Dispersant Effectiveness. Langmuir, 2021; 37(27), 8115-8128. doi: 10.1021/acs.langmuir.1c00651
Küster T, Bothun GD. In situ SERS detection of dissolved nitrate on hydrated gold substrates. Nanoscale Advances, 2021; 3, 4098-4105. doi: 10.1039/D1NA00156F
Ganji N., Bothun GD. Albumin protein coronas render nanoparticles surface active: consonant interactions at air-water and at lipid monolayer interfaces. Environmental Science: Nano, 2021; doi: 10.1039/D0EN00934B
Fedorenko M., Alesio J., Fedorenko A., Slitt A., Bothun GD. Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19F NMR. Chemosphere, 2021; 263, 128083. doi: 10.1016/j.chemosphere.2020.128083
Madani SZM, Safaee MM, Mitchell Gravely, et al. Carbon Nanotube-Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation. ACS Applied Nano Materials, 2020; 4(1), 331-342. doi: 10.1021/acsanm.0c02700
Abbasi A, Silva de Oliveira TT, Bothun GD, Bose A. Carbon Black Templated Gold Nanoparticles for Detection of a Broad Spectrum of Analytes by Surface Enhanced Raman Scattering (SERS). ACS Applied Nano Materials, 2020; 3(3), 2605–2613. doi: 10.1021/acsanm.0c00004
Fernandes JC, Agrawal NR, Aljirafi FO, et al. Does the Solvent in a Dispersant Impact the Efficiency of Crude-Oil Dispersion? Langmuir, 2019; 35(50), 16630-16639. doi: 10.1021/acs.langmuir.9b02184
Pan A, Jakaria MG, Meenach SA, Bothun GD. Radiofrequency and Near-Infrared Responsive Core–Shell Nanostructures Using Layersome Templates for Cancer Treatment. ACS Applied Bio Materials, 2019; 3(1), 273-281. doi: 10.1021/acsabm.9b00797
Hossain T, Bothun GD, Ilias S. Transport of Liquid and Supercritical CO2 and Selected Organic Solvents Through Surface Modified Mesoporous γ-alumina and Titania Membranes. Seperation Science and Technology, 2019; 54(13), 2098-2011. doi: 10.1080/01496395.2019.1594901
Omarova M, Swientoniewski LT, Tsengam IKM, et al. Biofilm Formation by Hydrocarbon-Degrading Marine Bacteria and Its Effects on Oil Dispersion. ACS Sustainable Chemistry & Engineering, 2019; 7(17), 14490-14499. doi: 10.1021/acssuschemeng.9b01923
Hossain T, Bothun, GD, Ilias S. Transport of Liquid and Supercritical CO2 and Selected Organic Solvents Through Surface Modified Mesoporous γ-Alumina and Titania Membranes. Separation Science and Technology, 2019; 1-14. doi: 10.1080/01496395.2019.1594901
Chakraborty S, Abassi A, Bothun G, et al. Phospholipid Bilayer Softening Due to Hydrophobic Gold Nanoparticle Inclusions. Langmuir, 2018. doi:10.1021
Abbasi A, Bothun GD, Bose A. Attachment of Alcanivorax borkumensis to Hexadecane-in-Artificial Sea Water Emulsion Droplets. Langmuir, 2018; 34(18), 5352-5357. doi: 10.1021/acs.langmuir.8b00082
Ganji N, Khan IA, Bothun GD. Surface Activity of Poly(ethylene glycol)-Coated Silver Nanoparticles in the Presence of a Lipid Monolayer. Langmuir, 2018; 34(5), 2039–2045. doi: 10.1021/acs.langmuir.7b03743

Recent Grants

7/20/2023. PI. National Science Foundation. “Collaborative Research: Magnetic Clustering using Novel Poly(amino acid) Corrals to Advance Magnetic Particle Imaging”
7/20/2023. PI. National Science Foundation. “Collaborative Research: Magnetic Clustering using Novel Poly(amino acid) Corrals to Advance Magnetic Particle Imaging”
7/20/2023. PI. National Science Foundation. “Collaborative Research: Magnetic Clustering using Novel Poly(amino acid) Corrals to Advance Magnetic Particle Imaging”
7/19/2023. PI. National Science Foundation. “Collaborative Research: Magnetic Clustering using Novel Poly(amino acid) Corrals to Advance Magnetic Particle Imaging”
6/15/2023. Co-PI. National Institutes of Health. “Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - Renewal”
5/22/2023. PI. Directorate for Engineering/NSF. “REU Supplement for NSF Grant Number 2002751”
9/13/2022. Co-PI. National Institutes of Health. “Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - Renewal”
1/25/2021. Co-PI. National Institute of Environmental Health Services. “GSO/CI/NIEHS - STEEP Year 5 Budget Request.”
1/25/2021. Co-PI. National Institute of Environmental Health Services. “GSO/CI/NIEHS - STEEP Year 5 Budget Request.”
4/6/2020. PI. National Science Foundation. “Accumulation and transformation of micro and Nano plastics within the sea surface microlayer.”
12/27/2018. PI. University of Maryland. “Molecular Engineering of Food-Grade Dispersants as Highly Efficient and Safe Products for the Treatment of Oil Spills”
10/3/2018. PI. University of Maryland. “Molecular Engineering of Food-Grade Dispersants as Highly Efficient and Safe Products for the Treatment of Oil Spills.”
9/30/2018. Co-PI. National Science Foundation. “Remotely Activated Biomaterial Scaffolds for Flexibly Directing the Recruitment and Differentiation of Bone Progenitor Cells.”
9/24/2018. Co-PI. National Institute of Health. “CI - STEEP - Sources, Transport, Exposure and Effects of Perfluoroalkyl Substances.”
9/20/2018. Co-PI. National Science Foundation. “RII Track-1: Enhancing Rhode Island's Coastal Environment to Enable Growth in a Blue Economy.”
9/10/2018. Co-PI. National Science Foundation. “MRI: Acquisition of a Confocal High Content Screening System to Enhance Bioengineering, and Biomedical Research.”
8/29/2018. PI. RI Science and Technology Advisory Council. “EPSCoR: RII Track 1: STAC Match.”
7/30/2018. PI. University of Maryland. “Molecular Engineering of Food-Grade Dispersants as Highly Efficient and Safe Products for the Treatment of Oil Spills.”
5/9/2018. Co-PI. National Institute of Health. “CI-STEEP-Sources, Transport, Exposure, and Effects of Perfluoroalkyl Substances.”
3/30/2018. Co-PI. National Institute of Health. “CI-STEEP-Sources, Transport, Exposure, and Effects of Perfluoroalkyl Substances.”
3/8/2018. PI. University of Maryland. “Molecular Engineering of Food-Grade Dispersants as Highly Efficient and Sale Products for the Treatment of Oil Spills.”
3/7/2018. PI. RI Science and Technology Advisory Council. “EPSCoR: RII Track 1: STAC match.”
10/4/2017. Co-PI. National Institute of Health. "CI - STEEP - Sources, Transport, Exposure and Effects of Perfluoroalkyl Substances."
9/22/2017. PI. RI Commerce Corporation. "Evaluation of a New Cleaning Process for Medical Devices."
9/21/2017. Co-PI. National Science Foundation. "RII Track-1: Enhancing Rhode Island's Coastal Environment to Enable Growth in a Blue Economy.”
8/11/2017. PI. University of Maryland. "Molecular Engineering of Food-Grade Dispersants as Highly Efficient and Safe Products for the Treatment of Oil Spills."
6/12/2017. PI. National Science Foundation. "Nanoparticle-Bacterial Membrane Interactions and Their Role in Nanotoxicology.”
1/31/2017. PI. University of Maryland. "Molecular Engineering of Food-Grade Dispersants as Highly Efficient and Safe Products for the Treatment of Oil Spills."

Honors & Awards

  • 2017 NSF CAREER Award

Additional Links

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