- Assistant Professor
- Department of Nutrition, Metabolism and Muscle Biology Lab
- Phone: 401.874.5869
- Email: email@example.com
- Office Location: Office Location: Fogarty Hall, Room 128
- Website: https://mariemortreux27.wixsite.com/m2b-lab
- NUT 207: General Nutrition
Dr. Mortreux is an Assistant Professor in the Department of Nutrition. Before starting at URI in 2022, she was an Instructor at Harvard Medical School (2019-2022) in Boston, MA.
Dr. Mortreux obtained her B.Sc (2010) and European M.Sc (2012) in genetics and life sciences, along with a European Magistere of Genetics (2012), which were combined to laboratory work in l’Universita Degli Studi di Padova, Italy , at the University of California San Francisco, USA, and at Université Paris Diderot Paris VII in Paris, France. Her majors included Genetics, Genomics, Neurosciences, Physiology and Physiopathology. She then received her Ph.D. in physiopathology/cell biology in Paris in April 2016.
She joined the Rutkove laboratory at Harvard Medical School to pursue her postdoctoral training focusing on NASA-funded studies. She created the first rat analog model of partial gravity, and studied musculoskeletal deconditioning and recovery, and used circulating miRNA and electrical impedance myography as new biomarkers. She then investigated the effects of resveratrol, a common polyphenol, as a mitigating countermeasure to prevent muscle deconditioning and assessed the impact of disuse on the circadian system.
Dr. Mortreux is currently Co-Investigator on 2 funded NASA-grants, one preclinical study and one clinical trial, and an active member of the NASA Analysis Working Group for the Animal Life Science Data Archive, an open-science endeavor.
Dr. Mortreux’s research focuses on the interaction and shared physiopathology between metabolism and muscle plasticity. Using rodent models, the MMB lab investigates how pathologies and diseases alter energy metabolism and circadian rhythm, and uses several nutraceutical approaches to mitigate muscle disuse and preserve muscle stem cells.
- Post-doctoral training, Harvard Medical School, Department of Neurology, Boston MA (2016-2019)
- PhD, neuro-physiopathology, Paris Diderot University, France, 2016
- Animal Experimentation Diploma, Pierre and Marie Curie University, France, 2015
- European MSc, genetics and neurosciences, Paris Diderot University, France, 2012
- European Magistere of Science, genetics and physiology, Paris Diderot University, France, 2012
- BSc, genetics and life sciences, Paris Diderot University, France, 2010
List of publications available on Google Scholar
Mortreux M, Rosa-Caldwell ME, Stiehl ID, Sung DM, Thomas NT, Fry CS, Rutkove SB. “Hindlimb suspension in Wistar rats: sex-based differences in muscle response”. Physiological Reports 2021 Oct;9(19):e15042. Doi:10.14814/phy2.15042
Pandeya S, Nagy JA, Riveros D, Semple C, Taylor R, Mortreux M, Sanchez B, Kapur K, Rutkove SB. “Predicting myofiber cross-sectional area and triglyceride content with electrical impedance myography: a study in db/db mice”. Muscle Nerve 2020. Doi:10.1002/mus.27095
Mortreux M & Rosa-Caldwell ME. “Approaching gravity as a continuum using the rat partial weight-bearing model”. Life 2020 10(10),235 doi:10.3390/life10100235
Semple C, Riveros D, Sung DS, Nagy JA, Rutkove SB, Mortreux M. ‘Using electrical impedance myography as a biomnarker of muscle deconditioning in rats exposed to micro- and partial- gravity analogs. Frontiers in Physiology 2020 doi:10.3389/fphys.2020.557796.
Semple C, Riveros D, Nagy JA, Rutkove SB, Mortreux M. ‘Partial weight-bearing in female rats: proof of concept in a Martian-gravity analog”. Frontiers in Physiology 2020 Apr 3 ;11 :302
Mortreux M, Riveros D, Semple C, Bouxsein ML, Rutkove SB. ‘The partial weight-bearing rat model using a pelvic harness does not impact stress or hindlimb blood flow”. Acta Astronautica 2020 (168):249-255
Mortreux M, Foppen E, Denis RG, Montaner M, Kassis N, Denom J, Vincent M, Fumeron F, Kujawski-Lafourcade M, Andreelli F, Balkau B, Marre M, Roussel R, Magnan C, Gurden H, Migrenne-Li S. “New roles for Protikineticin-2 in feeding behavior, insulin resistance and type 2 diabetes: studies in mice and humans”. Molecular Metabolism 2019 Nov (29):182-196
Mortreux M, Riveros D, Bouxsein ML, Rutkove SB. “A moderate daily dose of resveratrol mitigates muscle deconditioning in a Martian gravity analog”. Frontiers in Physiology 2019 Apr 4;(146):59327
Mortreux M, Nagy JA, Ko FC, Bouxsein ML, Rutkove SB. ‘A novel partial gravity ground-based analog for rats via quadrupedal unloading”. Journal of Applied Physiology 2018 Jul 1;125(1):175-182
Renon M, Legrand B, Blanc E, Daubigney F, Bokobza C, Mortreux M, Paul JL, Delabar JM, Rouach H, Andreau K, Janel N. ‘Impact of Dyrk1A level on alcohol metabolism”. Biochimica Biophysica Acta 2016 Sep;1862(9):1495-503