The 2024 annual report for the University of Rhode Island STEEP (Sources, Transport, Exposure & Effects of PFAS) Superfund Research Program, funded by the National Institute of Environmental Health Sciences, serves as a comprehensive overview of key research accomplishments and achievements in the realm of PFAS (Per- and Polyfluoroalkyl Substances). Across thematic areas, the report highlights significant progress in addressing environmental challenges, advancing biomedical knowledge, and fostering research excellence. It underscores STEEP’s commitment to advancing knowledge, fostering innovation, and addressing societal challenges through interdisciplinary research and collaboration. Furthermore, the report emphasizes the critical need for sustained support for research initiatives aimed at promoting environmental sustainability, enhancing healthcare outcomes, and nurturing the next generation of scientists and professionals.