Research

Dr. Van Nostrand has been working in Alzheimer’s disease (AD)research for more than 30 years, He was the first to purify and characterize amyloid precursor protein (APP), the progenitor of amyloid-beta (A-beta).  Van Nostrand’s research focuses on vascular-mediated aspects of cognitive impairment and dementia, which are key elements of AD and related disorders. Current studies include the causes of abnormal accumulation of A-beta in AD and a related condition called cerebral amyloid angiopathy (CAA). Van Nostrand has also developed transgenic animal models of disease which has helped to provide key insights into disease processes.