Research

  • $14,977,574All Federal Fiscal Year 2021 Research Funding
    23rdOut of 143 in 2021 federal research dollars to colleges of pharmacy

Overview

The College of Pharmacy’s extensive research is funded by over $15 million in extramural grants, research awards and industry partnerships. The College is ranked 10th out of 142 in 2018 NIH research dollars to colleges of pharmacy. Our state of the art laboratories and support clusters in Avedisian Hall are home to 35 faculty researchers and their research teams.


Focus Areas

Faculty in the URI College of Pharmacy are respected experts in the biomedical, clinical and applied pharmaceutical sciences. Their primary areas of research, interest, and expertise are outlined below. A searchable database of health and research expertise can be found at the Health Expert Database.


Drug Discovery

Where will we find the next generation of antibiotics? Can natural products augment or replace our current therapies for cancer and dementia? Many of humankind’s most devastating diseases have few or no effective therapies. Researchers in the College of Pharmacy are using a variety of approaches to identify and develop new strategies for treating antibiotic-resistant infections, cancer and neurodegenerative diseases. These investigators are collaborating with local and federal agencies and industry partners to translate laboratory results into real-world solutions.


Drug Delivery

Sustained release technologies, transporters, nanoparticles, powders and aerosols are among the drug delivery strategies being investigated today at the College of Pharmacy. Researchers are developing new approaches for delivering therapies across physiological barriers to enhance the treatment of a wide variety of diseases.


Pharmaceutical Chemistry

The development of new drugs and drug delivery strategies is dependent on a solid understanding of the chemistry of the medication and its vehicle. Pharmacy faculty employ a number of sophisticated technologies to probe the chemistry of organic and inorganic molecules, including Mass Spectrometry, NMR Spectroscopy, HPLC and nucleic acid synthesis and isolation. In many cases these investigators share their expertise and capabilities with pharmaceutical developers and manufacturers (large and small) in relationships that benefit the College as well as our industry partners.


Pharmacology

Pharmacologists in the College of Pharmacy possess expertise in a variety of sub-disciplines, including clinical pharmacology, drug metabolism, pharmacokinetics, pharmacodynamics, clinical study design and the analysis of drug response within populations. In many cases, these studies are designed to develop an understanding the sources of variability in drug disposition and effect and in the identification of individual factors that lead to altered drug response.


Toxicology

A number of the investigators in the College of Pharmacy study the consequences of exposure to environmental toxins. These investigators have particular interests in the relationships between the environment and Alzheimer’s disease, fatty liver disease, obesity and kidney disease. Their work has led to significant advancements in our understanding of the environment’s impact on the epigenome (factors that influence gene expression without changing the genetic code).


Pharmacotherapy

A large proportion of the College of Pharmacy faculty conduct research related to the practice of pharmacy. In some cases this work focuses on the treatment of a specific disease, such as diabetes, while in other instances the research involves the study of populations, e.g. the elderly. Many COP faculty members have a strong interest in developing practices that will improve the dissemination of drug-related information and enhance patient compliance.


Clinical Study Design and Analysis

The value of clinical studies is directly related to the quality of the study design and its subsequent analysis. A number of Pharmacy faculty members are recognized experts in this field. These investigators participate in a variety of partnerships and collaborations at the local, regional and national level.


Health Policy and Health Outcomes

The rapidly evolving nature of the healthcare marketplace in the United States requires that health-related decisions be appropriately informed by sound health policy and accurate economic analyses. Pharmacy faculty provide consulting and research support to government agencies and a variety of healthcare organizations and help to develop strategies that maximize the quality of care, improve strategic and operational efficiency and optimize the allocation of resources.

News

Facilities

Labs & Projects

  • Advanced Drug Delivery & Bioengineering Research Laboratory (Shen) - The Shen Lab is specialized in the areas of formulation development, manufacturing, in vitro and in vivo product performance testing, and development of in vitro-in vivo correlation (IVIVC) for advanced drug delivery systems and medical devices.
  • Antimicrobial Stewardship Program (Laplante) - A collaborative research program within the University of Rhode Island College of Pharmacy, the Antimicrobial Stewardship Program focuses on the prevention, treatment, virulence inhibition, and outcomes associated with drug resistant bacteria.
  • Bertin Lab - Access to molecular diversity from unusual biological sources is important to developing new natural products in the therapeutic realm. The Bertin Lab is addressing this access gap by discovering new metabolites from cyanobacterial blooms of Trichodesmium collected from the Gulf of Mexico.
  • Bioactive Botanical Laboratory (Seeram) - Inside URI’s Bioactive Botanical Research Lab, Pharmacy Professor Navindra Seeram has some big ideas about fighting cancer. Ideas so big that he’s regularly sought after by science and news publications around the globe for his expertise in the healing properties of medicinal plants.
  • Chemical Carcinogenesis Research (Cho) - Our research area is in chemical carcinogenesis with a major emphasis on the structural and synthetic aspects of DNA-adduct formation. Aromatic amine and polycyclic aromatic hydrocarbons are present in environment, thereby posing a threat to human health. I am particularly interested in how environmental carcinogens, upon metabolism, interact with cellular DNA and initiate mutagenesis/carcinogenesis. The […]
  • Clinical Pharmacokinetics and Pharmacodynamics (Rosenbaum) - Dr. Rosenbaum is applying modeling and simulation of drug response data as tools to more fully understand the time course and intensity of drug effects in man. She is interested in applying these methods in research to obtain a greater understanding of a drug’s properties in different populations.
  • Clinical Pharmacokinetics Research Laboratory (Akhlaghi) - The Clinical Pharmacokinetics Research Laboratory is specialized in the areas of effect of disease states on drug disposition, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and therapeutic drug monitoring (TDM). Located at the Kingston Campus of the University of Rhode Island, this laboratory is equipped with High Performance Liquid Chromatography (HPLC-UV, Hitachi) and ABI 3200 LC-Tandem Mass […]
  • Deng Lab - Dr. Deng’s research program is primarily focused on investigating bile acid and cholesterol homeostasis under physiological and pathological conditions. Disruption of bile acids and cholesterol homeostasis by genetic or environmental factors has been associated with various diseases.
  • Maple Maple Collaborative - Providing information to the maple benefits to promote the maple industry.
  • Nanotherapeutics & Biomaterials Engineering Laboratory (Menon) - The Dr. Menon lab’s research is centered on using drug delivery- and tissue engineering – based approaches to develop novel and effective solutions to cancer, fibrosis and inflammation. Our current research focuses are
  • Dr. Rowley working with students in his lab Natural Product Drug Discovery Research (Rowley) - One of the more frightening medical trends today is our growing resistance to antibiotics, which we take for everything from ear infections to life-threatening blood conditions. As people use antibiotics for more and more ailments, the ability of germs and bacteria to mutate and adapt has increased, often making them stronger than the medicines available […]
  • Rhode Island Infectious Diseases Research Program - Antimicrobial resistance is globally recognized as one of the greatest healthcare threats. Our research program is focused on the prevention, treatment, virulence inhibition and clinical outcomes associated with drug resistant bacteria. The program is divided into three divisions: the antimicrobial pharmacology division, the outcomes and pharmacoepidemiology division, and the implementation science outreach division.