The direction of the change in Cp is in keeping with the transporter’s function at each site. The magnitude of the change in Cp has been  arbitarily selected for clarity: absorption and excretion transporters were programed to produce about  a 2 fold change in F and renal clearance respectively

1. Observe the structure of the one compartment model with single IV bolus input   2. Observe how Cp changes over Time 3. Observe how the primary pharmacokinetic parameters, CL and Vd, influence the Cp-Time profile

1. Understand the physiological basis for the 2-compartment model 2.Observe the characteristics of the Cp-Time profile 3.Understand how the primary PK parameters influence the Cp-Time profile