1. Understand the structure of the indirect model 2. Understand the influence of model parameters on response 3. Appreciate the factors that control the onset magnitude and duration of response

1. Understand the structure of the indirect model 2. Understand the influence of model parameters on response 3. Appreciate the factors that control the onset magnitude and duration of response

1. Understand the structure of the indirect model 2. Understand the influence of model parameters on response 3. Appreciate the factors that control the onset magnitude and duration of response

1. Understand the characteristics of the transit compartment model 2. Observe how the response profile changes between compartments 3. Observe how the response is influenced by the dose 4. Observe how the response is influenced by the number of compartments and by the total mean transit time

1. Use the model for nicotine’s effect on heart rate to demonstrate how tolerance    can be modeled using a hypothetical metabolite that acts as a drug antagonist 2. Observe how the model can be used to understand the time course of     tolerance and to plan compensatory strategies to minimize drug tolerance

1. Present the structure of a PD model for the hematological toxicty 2. Observe the onset, duration of, and recovery from, drug-induced neutropenia 3. Observe how a drug’s PK and PD effects the duration and intensity of neutropenia

1. Understand how irreversible drug effects can be modeled 2. Observe the time course of plasma concentrations and response 3. Using a simulation model based on disolvprazole (see text), observe how     irreversible drug effects impact the design of dosing regimens