- Professor, Director of Research Development
- Office: 395D Lab: 340
- Phone: 401.874.5020
- Email: aslitt@uri.edu
- Office Location: Avedisian Hall, 7 Greenhouse Road, Kingston, RI 02881
Research
Dr. Slitt’s research interests focus on how 1) expression of drug transporters affects chemical (i.e. drug and environmental chemical) disposition and toxicity, 2) nutrition and intake of dietary antioxidants affects the expression of drug transporters, 3) liver disease (i.e. diabetes, cholestasis, and ethanol cirrohsis) affects transporter expression and chemical disposition, and 4) transporter expression affects cholesterol transport and susceptibility to gallstone formation.
Education
Postdoctoral Fellowship, University of Kansas Medical Center, 2000-2004
Ph.D., University of Connecticut, Pharmaceutical Sciences (Pharmacology and Toxicology), 2000
B.S., University of Connecticut, Molecular and Cellular Biology, 1995
Selected Publications
Merrell MD, Augustine LM, Slitt A.L., Cherrington NJ. Induction of drug metabolism enzymes and transporters by oltipraz in rats. J Biochem Mol Toxicol. 2008;22:128-35.
Augustine LM, Fisher CD, Lickteig AJ, Aleksunes LM, Slitt A.L., Cherrington NJ.Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats. J Biochem Mol Toxicol. 2008;22:93-100.
Cheng Q, Aleksunes LM, Manautou JE, Cherrington NJ, Scheffer GL, Yamasaki H, and Slitt AL. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol. Pharm., 2008, 5:77-91.
Ahern, L.D., Besselsen, D.G., Kulkarni, S., Cheng, Q., Slitt, A.L., and Cherrington, N.J. Induction of Hepatic Transporter Proteins Protects Against LCA-Induced Intrahepatic Cholestasis, Toxicology and Applied Pharmacology, 2008, 226:74-83.
Aleksunes, L.M.A, Slitt, A.L.,Maher, J.M., Augustine, L.M., Goedken, M., Chan, J.Y., Cherrington, N.J., Klaassen, C.D., and Manautou, J.E. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2 transcription factor. Toxicology and Applied Pharmacology, 2008, 226:74-83.
Maher J.M., Dieter M.Z., Aleksunes L.M., Slitt A.L., Guo G., Tanaka Y., Scheffer G.L., Chan J.Y., Manautou J.E., Chen Y., Dalton T.P., Yamamoto M., Klaassen C.D. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology. 2007, 46(5):1597-610.
Lickteig A.J., Fisher C.D., Augustine L.M., Aleksunes L.M., Besselsen D.G., Slitt A.L., Manautou J.E., Cherrington N.J. Efflux Transporter Expression and Acetaminophen Metabolite Excretion are Altered in Rodent Models of Non-Alcoholic Fatty Liver Disease. Drug Metab Dispos. 2007, 35:1970-8.