Biography

Dr. Schrader’s primary field of study and research interests are Neuroscience and
Neuropharmacology. In the past, this included mechanisms antipsychotic drug action and molecular functions of the D2 Dopamine Receptor. Currently, his research has shifted to cerebral small vessel diseases (CSVD) and Alzheimer’s Disease Related Disorders, with a particular focus on Cerebral Amyloid Angiopathy (CAA). This work has included proteomic analysis of CSVD animal models using protein mass spectroscopy for elucidation of disease mechanisms and diagnostic biomarker discovery.

Education

PhD in Pharmaceutical Sciences (Pharmacology/Toxicology), College of Pharmacy, University of Rhode Island, 2017

Selected Publications

Schrader JM, Irving CM, Octeau JC, Christian JA, Aballo TJ, Kareemo DJ, et al. The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface. J Biol Chem. 2019 Apr 5;294(14):5604–15.

Octeau JC, Schrader JM, Masuho I, Sharma M, Aiudi C, Chen CK, et al. G Protein Beta 5 Is Targeted to D2-Dopamine Receptor-Containing Biochemical Compartments and Blocks Dopamine-Dependent Receptor Internalization. PLoS One [Internet]. 2014 Aug 27 [cited 2015 Jun 1];9(8). Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146516/
Schrader JM, Xu F, Van Nostrand WE. Distinct brain regional proteome changes in the rTg-DI rat model of cerebral amyloid angiopathy. Journal of Neurochemistry. 2021;159(2):273–91.

Schrader JM, Xu F, Lee H, Barlock B, Benveniste H, Van Nostrand WE. Emergent White Matter Degeneration in the rTg-DI Rat Model of Cerebral Amyloid Angiopathy Exhibits Unique Proteomic Changes. The American Journal of Pathology. 2022 Mar 1;192(3):426–40.

Stanisavljevic A, Schrader JM, Zhu X, Mattar JM, Hanks A, Xu F, et al. Impact of Non- pharmacological Chronic Hypertension on a Transgenic Rat Model of Cerebral Amyloid Angiopathy. Front Neurosci. 2022 Mar 15;16:811371.

Schrader JM, Stanisavljevic A, Xu F, Van Nostrand WE. Distinct Brain Proteomic Signatures in Cerebral Small Vessel Disease Rat Models of Hypertension and Cerebral Amyloid Angiopathy. Journal of Neuropathology & Experimental Neurology. 2022 Jul 20;nlac057.