Navindra Seeram, Ph.D.

Navindra Seeram
Research Website

 

Biography

Navindra P. Seeram, Ph.D., is a Professor and Chair of the Biomedical and Pharmaceutical Sciences Department in the College of Pharmacy at the University of Rhode Island (URI). Prior to this, he served as the Assistant Director of the UCLA Center for Human Nutrition in the Department of Medicine at the University of California at Los Angeles (UCLA) for 5 years. Dr. Seeram’s research group, the Bioactive Botanical Research Laboratory, investigates medicinal plants and their derived natural products for preventive and therapeutic effects against chronic human diseases. He has co/authored over 220 original peer-reviewed research articles, 11 review articles, 18 book chapters and is a co/inventor on 8 US patents. He has co-edited 3 books and is the founding editor of the Clinical Pharmacognosy book series published by CRC Press/Taylor and Francis. He serves as a Consultant and Scientific Advisor of several Life Science companies, on the advisory board of the American Botanical Council, and on the editorial advisory boards of the Journal of Agricultural and Food Chemistry, and ACS Food Science and Technology.  He was the recipient of the 2019 Distinguished Service Award and 2009 Young Scientist Award from the Division of Agricultural and Food Chemistry of the American Chemical Society and served as the 2017 Chair of that Division. His research is impactful on his field (Google h–index = 80) and he is regularly quoted in the media and popular press about medicinal plants.  He conducted his undergraduate, doctoral, and postdoctoral studies at the University of Guyana (South America), the University of the West Indies (Jamaica) and at Michigan State University, respectively. 

Research

Bioassay-guided discovery of natural products from medicinal plants including medicinal foods targeting neurodegenerative diseases, cancer, diabetes, and inflammation; Investigation of bioavailability, metabolism, tissue disposition, and mechanisms of action of bioactive food components.

Education

Post-Doctoral Fellow, Michigan State University, 1999-2002
Ph.D. Natural Products Chemistry, University of the West Indies, Kingston, Jamaica, 1998
B.Sc., Chemistry (major) & Biology (minor) with Distinction, University of Guyana, Georgetown, Guyana, South America, 1990.

Selected Publications

Original Articles in Peer-Reviewed Journals

  1. Li, H.; Puopolo, T.; Seeram, N.P.; Liu, C.; Ma, H. Anti-ferroptotic effect of cannabidiol in human skin keratinocytes characterized by data-independent acquisition-based proteomics. Journal of Natural Products, 2024. DOI: 10.1021/acs.jnatprod.3c00759
  2. Li, H.; Deng, N.; Puopolo, T.; Jiang, X.; Seeram, N.P.; Liu, C.; Ma, H. Cannflavins A and B with anti-ferroptosis, anti-glycation, and antioxidant activities protect human keratinocytes in a cell death model with erastin and reactive carbonyl species. Nutrients, 2023. 15, 4565. DOI: 10.3390/nu15214565
  3. Puopolo, T.; Cai, A.; Liu, C.; Ma, H.; & Seeram, N.P. Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking. Heliyon, 2023, 9, e21265. DOI: /10.1016/j.heliyon.2023.e21265
  4. Puopolo, T.; Li, H.; Gutkowski, J.; Cai, A.; Seeram, N.P.; Ma, H.; Liu, C. Establishment of human PD-1/PD-L1 blockade assay based on surface plasmon resonance (SPR) biosensor. Bio-protocol, 2023, 13(15). DOI: 10.21769/BioProtoc.4765
  5. Puopolo, T.; Li, H.; Ma, H.; Schrader, J.; Liu, C.; and Seeram, N.P. Uncovering the anti-inflammatory mechanisms of phenolic-enriched maple syrup extract in lipopolysaccharide-induced peritonitis in mice: Insights from data-independent acquisition proteomics analysis. Food & Function, 2023. 14, 6690-6706. DOI: 10.1039/D3FO01386C.
  6. Ressler, A.J.; Frate, M.; Hontoria, A.; Ream, A.; Timms, E.; Li, H.; Stettler, L.D.; Bollinger, A.; Poor, J.E.; Parra, M.A.; Ma, H.; Seeram, N.P.; Meschwitz, S.M.; Henry, G.E. Synthesis, anti-ferroptosis, anti-quorum sensing, antibacterial and DNA interaction studies of chromene-hydrazone derivatives. Bioorganic & Medicinal Chemistry, 2023, 117369. DOI: 10.1016/j.bmc.2023.117369.
  7. Puopolo, T.; Li, H.; Ma, H.; Schrader J.M.; Liu, C.; Seeram, N.P. Uncovering the anti-inflammatory mechanisms of phenolic-enriched maple syrup extract in lipopolysaccharide-induced peritonitis in mice: insights from data-independent acquisition proteomics analysis. Food & Function, 2023, DOI: 10.1039/D3FO01386C.
  8. Boateng, S.T;  Roy, T.; Torrey, K.; Owunna, U.; Banang-Mbeumi, S.; Basnet, D.; Niedda, E.; Alexander, A.D.; Hage, D.E.; Atchimnaidu, S.; Nagalo, B.M.; Aryal, D.; Findley, A.; Seeram, N.P.; Efimova, T.; Sechi, M.; Hill, R.A.; Ma, H.; Chamcheu, J.C.; Murru, S. Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38:1, DOI: 10.1080/14756366.2023.2205042
  9. Bollinger, A.; Brandt, O.; Stettler, L.; Ream, A.; Kopysciansky, V.; Nelson, C.; Slitt, A.; Ma, J.; Tom, L.A.; Ma, H.; Seeram, N.P.; Henry, G.E. Sulfide-linked 3, 4, 5-trimethoxyphenyl-thiosemicarbazide/triazole hybrids: Synthesis, antioxidant, antiglycation, DNA cleavage and DNA molecular docking studies. Results in Chemistry, 2023, 100806. DOI: 10.1016/j.rechem.2023.100806
  10. Torrey, K.J.; Liu, Y.; Li, H.; Ma, H.; Via, C.W.; Bertin, M.J.; Seeram, N.P. What is authentic maple water? A twelve-month shelf-life study of the chemical composition of maple water and its biological activities. Foods, 2023, 12, 239. DOI: 10.3390/foods12020239.
  11. Huang, S.; Li, H.; Xu, J.; Zhou, H.; Seeram, N.P.; Ma, H.; Gu, Q. Chemical constituents of industrial hemp roots and their anti-inflammatory activities. Journal of Cannabis Research, 2023, 5, DOI: 1. 10.1186/s42238-022-00168-3.
  12. Ressler, A.J.; Brandt, O.N.; Weaver, A.; Poor, J.E.; Ream, A.; Summers, N.A.; McMillen, C.D.; Seeram, N.P.; Dougherty, W.G.; Henry, G.E. Chromene-based schiff base ligand: DNA interaction studies and characterization of tetranuclear Zinc, Nickel and Iron complexes. Inorganica Chimica Acta, 2022, 121363. DOI: 10.1016/j.ica.2022.121363.
  13. Puopolo, T.; Chang, T.; Liu, C.; Li, H.; Liu, X.; Wu, X.; Ma, H.; Seeram, N.P. Gram-scale preparation of cannflavin A from hemp (Cannabis sativa L.) and its inhibitory effect on tryptophan catabolism enzyme kynurenine-3-monooxygenase. Biology, 2022, 11, 1416. DOI:10.3390/biology11101416.
  14. Kirk, R.D.; Akanji, T.; Li, H.; Shen, J.; Allababidi, S.; Seeram, N.P.; Bertin, M.J.; Ma, H. Evaluations of skin permeability of cannabidiol and its topical formulations by skin membrane-based parallel artificial membrane permeability assay and Franz cell diffusion assay. Medical Cannabis and Cannabinoids, 2022. DOI: 10.1159/000526769
  15. Liu, C.; Puopolo, T.; Li, H.; Cai, A.; Seeram, N.P.; Ma, H. Identification of SARS-CoV-2 main protease inhibitors from a library of minor cannabinoids by biochemical inhibition assay and surface plasmon resonance characterized binding affinity. Molecules, 2022, 27, 6127. DOI: 10.3390/molecules27186127
  16. Li, H.; Seeram, N.P.; Liu, C.; Ma, H. Further investigation of blockade effects and binding affinities of selected natural compounds to immune checkpoint PD-1/PD-L1. Frontiers in Oncology, 2022. DOI: 10.3389/fonc.2022.995461.
  17. Luo, Z.; He, H.; Tang, T.; Zhou, J.; Li, H.; Seeram, N.P.; Li, D.; Zhang, K.; Ma, H.; Wu, P. Synthesis and biological evaluations of betulinic acid derivatives with inhibitory activity on hyaluronidase and anti-inflammatory effects against hyaluronic acid fragment induced inflammation. Frontiers in Chemistry, 2022, 10, 892554. DOI: 10.3389/fchem.2022.892554.
  18. Puopolo, T.; Liu, C.; Ma, H.; Seeram, N.P. Inhibitory effects of cannabinoids on acetylcholinesterase and butyrylcholinesterase enzyme activities. Medical Cannabis and Cannabinoids, 2022, 5, 85-94. DOI: 10.1159/000524086.
  19. Liu, C.; Cai, A.; Li, H.; Deng, N.; Cho, B.P.; Seeram, N.P.; Ma, H., Characterization of molecular interactions between cannabidiol and human plasma proteins (serum albumin and γ-globulin) by surface plasmon resonance, microcalorimetry, and molecular docking. Journal of Pharmaceutical and Biomedical Analysis, 2022, 214, 114750. DOI: 10.1016/j.jpba.2022.114750.
  20. Xue, L.; Liu, C.; Ma, H.; Seeram, N.P.; Neto, C.C. Anti-inflammatory activities of cranberry fruit extracts in human THP-1 monocytes are influenced by their phytochemical composition. ACS Food Science & Technology, 2022. DOI: 10.1021/acsfoodscitech.1c00324
  21. Andrews, F.M.; Riggs, L.M.; Lopez M.J.; Keowen, M.L.; Garza Jr, F.; Takawira, C.; Liu, C.C.; Liu, Y.; Seeram, N.P.; Cairy, A.; St. Blanc, M. Effect of an oral supplement containing curcumin extract (Longvida®) on lameness due to osteoarthritis and gastric ulcer scores. Equine Veterinary Education, 2022, DOI: 10.1111/eve.13616
  22. Li, H.; Xu, F.; Liu, C.; Cai, A.; Dain, J..; Li, D.; Seeram, N.P.; Cho, B.P.; Ma, H. Inhibitory effects and surface plasmon resonance based binding affinities of dietary hydrolyzable tannins and their gut microbial metabolites on SARS-CoV-2 main protease. Journal of Agricultural and Food Chemistry, 2021, doi: 10.1021/acs.jafc.1c03521.
  23. Li, H.; He, H.; Liu, C.; Akanji, T.; Gutkowski, J.; Li, R.; Ma, H.; Wan, Y.; Wu, P.; Li, D.; Seeram, N.P., Ma, H. Dietary polyphenol oleuropein and its metabolite hydroxytyrosol are moderate skin permeable elastase and collagenase inhibitors with synergistic cellular antioxidant effects in human skin fibroblasts. International Journal of Food Sciences and Nutrition, 2021, DOI: 10.1080/09637486.2021.1996542.
  24. Rose, K.N.; Barlock, B.J.; DaSilva, N.A.; Johnson, S.L.; Liu, C.; Ma, H.; Nelson, R.; Akhlaghi, F.; Seeram N.P. Anti-neuroinflammatory effects of a food-grade phenolic-enriched maple syrup extract in a mouse model of Alzheimer’s disease. Nutritional Neuroscience, 2021, 24, 710-719. 
  25. Johnson, S.L.; Lu, Y. Ma, H.; Seeram, N.P.; Yuan, T. Compounds from Mucuna pruriens seeds and their neuroprotective effects. Chemistry of Natural Compounds, 2021, 57 (3). DOI: 10.1007/s10600-021-03425-8.
  26. He, H.; Li, H.; Akanji, T.; Niu, S.; Luo Z.; Li, D.; Seeram, N.P.; Wu, P.; Ma, H. Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeability. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 1665-1678. DOI: 10.1080/14756366.2021.1956487.
  27. Guo, H.; Liu, C.; Tang, Q.; Li, D.; Wan, Y.; Li, J.; Gao, X.; Seeram, N.P.; Ma, H.; Chen, H. Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress. Journal of Functional Foods. 2021, 83, 104564.
  28. Ma, H.; Li, H.; Liu, C.; Seeram, N. P. Evaluation of cannabidiol’s inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids. Journal of Cannabis Research, 2021, 3, 1-6.
  29. Liu, C.; Li, H.; Xu, F.; Jiang, X.; Ma, H.; Seeram, N.P. Cannabidiol protects human skin keratinocytes from hydrogen-peroxide-induced oxidative stress via modulation of the caspase-1–IL-1β axis.  Journal of Natural Products, 2021, 84, 1563-1572. DOI:  10.1021/acs.jnatprod.1c00083
  30. Pfohl, M.; DaSilva, N.A.; Marques, E.; Agudelo, J.; Liu, C.; Goedken, M.; Slitt, A.L.; Seeram, N.P.; Ma, H. Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice. International Journal of Food Sciences and Nutrition, 2021, 72, 499-510. DOI: 10.1080/09637486.2020.1849041.
  31. Iannucci, J.; Johnson, S.L.; Majchrzak, M.; Barlock, B.J.; Akhlaghi, F.; Seeram, N.P.; Sen, A.; and Grammas, P. Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer’s disease mouse model. Biochemistry and Biophysics Reports, 2020, 24,100862. DOI:10.1016/j.bbrep.2020.100862
  32. Liu, C.; Ma, H.; Slitt, A.; Seeram, N. P. Inhibitory effect of cannabidiol on the activation of NLRP3 inflammasome activation is associated with its modulation of the P2X7 receptor in human monocytes. Journal of Natural Products, 2020, 83, 2025-2029.
  33. Ma, H.; Xu, F.; Liu, C.; Seeram, N. P. A network pharmacology approach to identify potential molecular targets for cannabidiol’s anti-inflammatory activity. Cannabis and Cannabinoid Research, 2020, https://doi.org/10.1089/can.2020.0025.
  34. Liu, C.; Xu, Y.; Kirk, R.D.; Li, H.; Li, D.; DaSilva, N.A.; Bertin, M.J.; Seeram, N.P.; Ma, H., Inhibitory effects of skin permeable glucitol-core containing gallotannins from red maple leaves on elastase and their protective effects on human keratinocytes. Journal of Functional Foods, 2020, 75, 104208.
  35. Johnson, S.L.; Park, H.Y.; Vattem, D.A.; Grammas, P.; Ma, H.; Seeram, N.P. Equol, a blood–brain barrier permeable gut microbial metabolite of dietary isoflavone daidzein, exhibits neuroprotective effects against neurotoxins induced toxicity in human neuroblastoma SH-SY5Y cells and Caenorhabditis elegans. Plant Foods for Human Nutrition, 2020, https://doi.org/10.1007/s11130-020-00840-0
  36. Killian, C.; Johnson, S.L.; Ma, H.; McKeown, B.; McDougall, L.; Hurta, R.; Liu, Y.; Seeram, N.P. Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa. Natural Product Research, 2020, https://doi.org/10.1080/14786419.2020.1784174
  37. Muhsinah, A.B.; Nugroho, A.E.; Li, H.; Lazzaro, S.; DaSilva, N.A.; Li, D.; Ma, H.; Alsayari, A.; Morita, H.; Liu, Y.; Seeram, N.P. Saudiarabicains A-E, bioactive 19-acetoxyingol diterpenoids from Euphorbia saudiarabica. Tetrahedron Letters, 2020, 61, 152203.
  38. Li, H.; DaSilva, N.A.; Liu, W.; Xu, J.; Dombi, G.W.; Dain, A.A.; Li, D.; Chamcheu, J.C.; Seeram, N.P.; Ma, H. Thymocid®, a standardized black cumin (Nigella sativa) seed extract, modulates collagen cross-linking, collagenase and elastase activities, and melanogenesis in murine B16F10 melanoma cells. Nutrients, 2020, 12, 2146.
  39. Johnson, S.L.; Iannucci, J.; Seeram, N.P.; Grammas, P. Inhibiting thrombin improves motor function and decreases oxidative stress in the LRRK2 transgenic Drosophila melanogaster model of Parkinson’s disease. Biochemical and Biophysical Research Communications, 2020, 527, 532-538.
  40. Castner, E.; Dickson, M.; Mykytyn, A.; Seeram, N.P.; Henry, G.E.; Vivekanand, P. Synthesis and evaluation of apoptotic induction of human cancer cells by ester derivatives of thujone. Medicinal Chemistry Research, 2020, 29, 268-280, doi 10.1007/s00044-019-02481-8.
  41. Liu, C.; Guo, H.; Dain, J. A.; Wan, Y.; Gao, X. H.; Chen, H. D.; Seeram, N. P.; Ma, H. Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes. Food & Function, 2020, DOI: 10.1039/d0fo00359j.
  42. Li, L.; Ma, H.; Liu, T.; Ding, Z.; Liu, W.; Gu, Q.; Mu, Y.; Xu, J.; Seeram, N.P.; Huang, X. and Xu, J., Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice. Journal of Functional Foods, 2020, 70, 103970.
  43. Sheng, J.; Liu, C.; Petrovas, S.; Wan, Y.; Chen, H.D.; Seeram, N.P.; Ma, H. Phenolic-enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity. Dermatologic Therapy, 2020;e13426;  https://doi.org/10.1111/dth.13426.
  44. Espinosa, A.; Paz-Y-Miño-C, G.; Santos, Y.; Ma, H.; Nadeau, M.; Seeram, N.P; Rowley, DC. Anti-amebic effects of Chinese rhubarb (Rheum palmatum) leaves’ extract, the anthraquinone rhein and related compounds. Heliyon. 2020, 1;6(4):e03693. doi: 10.1016/j.heliyon.2020.e03693.
  45. Fan, Q.; Liu, Y.; Wang, X.; Zhang, Z.; Fu, Y.; Liu, L.; Wang, P.; Ma., H.; Ma, H.; Seeram, N.P.; Zheng, J.; Zhou, F. Ginnalin A inhibits aggregation, reverses fibrillogenesis and alleviates cytotoxicity of amyloid-b (1-42).  ACS Chemical Neuroscience.  2020, 11, 638-647.
  46. Havasi, M.H.; Ressler, A.J.; Parks, E.L.; Cocolas, A.H.; Weaver, A.; Seeram, N.P.; Henry, G.E. Antioxidant and tyrosinase docking studies of heterocyclic sulfide derivatives containing a thymol moiety.  Inorganica Chimica Acta, 2020, 119495.
  47. Sun, J.; Deering, R.; Peng, Z.; Najia, L.; Khoo, C.; Cohen, P.; Seeram, N.P.; Rowley, D. Pectic oligosaccharides from cranberry prevent quiescence and persistence in the uropathogenic Escherichia coli CFT 073. Scientific Reports, 2019, 9, 1–9. https://doi.org/10.1038/s41598-019-56005-w.
  48. Cocolas, A.H.; Parks, E.L.; Ressler, A.J.; Havasi, M.H.; Seeram, N.P.; Henry, G.E. Heterocyclic b-keto sulfide derivatives of carvacrol: Synthesis and copper (II) ion reducing capacity. Bioorganic and Medicinal Chemistry Letters, 2019, 126636. doi: 10.1016/j.bmcl.2019.12663.
  49. Xu, W.; Zhang, L.; Omar R.; Liu, W.; Wei, Z.; Zhang Z.; Mu, Y.; Seeram, N.P.; Huang, X.; Ma, H.; Li, L. Barringtogenol C-type triterpenoid saponins from the stem bark of Norway maple (Acer platanoides). Planta Medica, 2019, DOI: 10.1055/a-1031-7283.
  50. Chen, F.; Tang, Q.; Ma, H.; Bian, K.; Seeram, N.P.; Li. D. Hydrolyzable tannins are iron chelators that inhibit DNA repair enzyme ALKBH2. Chemical Research Toxicology, 2019, 32, 1082-1086, doi: 10.1021/acs.chemrestox.8b00398.
  51. Brotzman, N.; Xu, Y.; Graybill, A.; Cocolas, A.; Ressler, A.; Seeram, N.P.; Ma, H.; Henry, G.E. Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol. Bioorganic and Medicinal Chemistry Letters, 2019, 29, 56-58.
  52. Johnson, S.L.; Kirk, R.D.; DaSilva, N.A.; Ma, H.; Seeram, N.P.; Bertin, M.  Polyphenol microbial metabolites exhibit gut and blood-brain barrier permeability and protect murine microglia against LPS-induced inflammation.  Metabolites, 2019, 9, E78; doi:10.3390/metabo9040078
  53. Xu, J.; Liu, T.; Li, Y.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N.P.; Mu, Y.; Hwang, X.; Li, L. Jamun (Eugenia jambolana) fruit extract prevents obesity by modulating the gut microbiome in high-fat-fed-diet mice. Molecular Nutrition Food Research, 2019, 1801307; doi: 10.1002/mnfr.201801307.
  54. Liu, C.; Guo, H.; Dasilva, N.A.; Li, D.L.; Zhang, K.; Wan, Y.S.; Gao, X.H.; Chen, H.D.; Seeram, N.P.; Ma, H. Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes. Journal of Functional Foods, 2019, 54, 559-567.
  55. Lu, W.; Cai, A.; Carley, R.; Rocchio, R.; Petrovas, Z.A.; Chartier, C.A.; Meng, X.; Su, J.; Cho, B.P.; Dain, J.A.; Ma, H.; Seeram, N.P. Bioactive anthraquinones found in plant foods interact with human serum albumin and inhibit the formation of advanced glycation endproducts. Journal of Food Bioactives, 2018, 4, 130-138.
  56. Rose, K.; Wan, C.; Thomas, A.; Seeram, N.P.; Ma, H. Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective properties. Natural Products Communications, 2018, 13, 1309-1311.
  57. Johnson, S.L.; Park, H.Y.; DaSilva, N.A.; Vattem, D.A.; Ma, H.; Seeram, N.P. Levodopa-reduced Mucuna pruriens seed extract shows neuroprotective effects against Parkinson’s disease in murine microglia and human neuroblastoma cells, Caenorhabditis elegans and Drosophila melanogaster.  Nutrients, 2018, 10, pii:E1139. doi: 10.3390/nu10091139.
  58. Liu, Y.; Seeram, N.P. Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements. Journal of Separation Science, 2018, 41, 3022-3033.
  59. Xu, J.; Liu, T.; Li, Y.; Yuan, C.; Ma, H.; Seeram, N.P.; Liu, F.; Mu, Y.; Huang, X.; Li, L. Hypoglycemic and hypolidemic effects of triterpenoid-enriched Jamun (Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type-1 diabetic mice.  Food and Function, 2018, 9, 3330-3337. doi: 10.1039/c8fo00095f.
  60. Liu, F.; Ma, H.; Wang, G.; Seeram, N.P.; Mu, Y.; Xu, Y.; Huang, X.; Li, L. Phenolics from Eugenia jambolana seeds with advanced glycation endproduct formation and alpha-gucosidase inhibitory activities.  Food and Function, 2018, 9, 4246-4254.  doi: 10.1039/c8fo00583d.
  61. Li, C.; Seeram, N.P. Ultra-fast liquid chromatography coupled with electrospray ionization/time-of-flight mass spectrometry for rapid phenolic profiling of red maple (Acer rubrum) leaves.  Journal of Separation Science, 2018, 41, 2331-2346. doi: 10.1002/jssc.201800037.
  62. Liu, Y.; Siard, M.; Adams, A.; Keowen, M.L.; Miller, T.K.; Garza, F.; Andrews, F. M.; Seeram, N.P. Simultaneous quantification of free curcuminoids and their metabolites in equine plasma by LC-ESI-MS/MS.  Journal of Pharmaceutical and Biomedical Analysis, 2018, 154, 31-39.
  63. Ma, H.; Johnson, S.L.; Liu, W.; DaSilva, N.A.; Meschwitz, S.; Dain, J.A.; Seeram, N.P. Evaluation of polyphenol anthocyanin-enriched extracts of blackberry, black raspberry, cranberry, red raspberry and strawberry for free radical scavenging, reactive carbonyl species trapping, anti-glycation, anti-b-amyloid aggregation, and microglial neuroprotective effects. International Journal of Molecular Science, 2018, 19, 461. doi:10.3390/ijms19020461.
  64. Luo, X.K.; Cai, J.; Luo, P.; Li, C.J.; Ma, H.; Liu, Z.; Seeram, N.P.; Gu, Q.; Xu, J. Fluvirosaones A and B, two indolizidine alkaloids with a pentacyclic skeleton from Fluegga virosa. Organic Letters, 2018, 4, 991-994.
  65. Xu, J.; Yuan, C.; Wang, G.; Luo, J.; Ma, H.; Xu, L.; Mu, Y.; Seeram, N.P.; Huang, X.; Li, L. Urolithins attenuate LPS-induced neuroinflammation in BV2 microglia via MAPK, AkT, and NF-kB signaling pathways.  Journal of Agricultural and Food Chemistry, 2018, 66, 571-580.
  66. Liu, F.; Liu, C.; Liu, W.; Zhanjun, D.; Ma, H.; Seeram, N.P.; Xu, L.; Mu, Y.; Huang, X.; Li, L. New sesquiterpenoids from Eugenia jambolana seeds and their anti-microbial activities.  Journal of Agricultural and Food Chemistry, 2017, 65, 10214-10222.
  67. Kim, B.; Park, Y-K.; Bae, M.; Ma, H.; Yuan, T.; Seeram, N.P.; Lee, J-Y. Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells. European Journal of Nutrition, 2017, doi: 10.1007/s00394-017-1506-z. 
  68. DaSilva, N.A.; Nahar, P.P.; Ma, H.; Eid, A.; Meschwitz, S.; Zawia, N.; Slitt, A.; Seeram, N.P. Pomegranate ellagitannin-gut derived metabolites, urolithins, inhibit neuroinflammation in vitro.  Nutritional Neuroscience, 2017, doi: 10.1080/1028415X.2017.1360558. 
  69. Liu, Y.; Rose, K.N; DaSilva, N.A.; Johnson, S.L.; Seeram, N.P. Isolation, identification, and biological evaluation of phenolic compounds from a traditional North American confectionery, maple sugar.  Journal of Agricultural and Food Chemistry, 2017, 65, 4289-4295.
  70. Ma, H.; Xu, J.; DaSilva, N.; Wang, L.; Wei, Z.; Guo, L.; Lu, W.; Xu, J.; Xu, Q.; Seeram, N.P. Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract:  Inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells. Archives of Dermatological Research, 2017, 309, 265-274.
  71. Liu, W.; Wei, Z,; Ma, H.; Cai, A.; Liu, Y.; Sun, J.; Kirshenbaum, L.;  Cho, B.;  Dain, J.A.; Rowley, D.C.; Shaikh, Z.; Seeram, N.P. Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells, Food and Function, 2017, 8, 757-766.
  72. Liu, F.; Yuan, T.; Liu, W.; Ma, H.; Seeram, N.P.; Yuanyuan, L.; Mu, Y.; Huang, X.; Li, L. Phloroglucinol derivatives with protein tyrosinase phosphatase 1B inhibitory activities from Eugenia jambolana seeds.  Journal of Natural Products, 2017, 80, 544-550.
  73. Rafter, J.L.; Gonda-King, L.; Niesen, D.; Seeram, N.P.; Rigsby, C.M.; Preisser, E.L. Impact of consuming ‘toxic’ monarch caterpillars on Chinese mantid growth and fecundity. Insects, 2017, 8, E23; doi:10.3390/insects8010023.
  74. Rafter, J.L.; Vendettuoli, J.F.; Gonda-King, L.; Niesen, D.; Seeram, N.P.; Rigsby, C.M.; Preisser, E.L.  Pretty picky for a generalist: Impacts of toxicity and nutritional quality on mantid prey processing. Environmental Entomology. 2017, 46, 626-632.
  75. Li, Y.; Xu, J.; Yuan, C.; Ma, H.; Liu, T.T.; Liu, F.; Seeram, N.P.; Mu, Y.; Huang, X.; Li, L. Chemical composition and anti-hyperglycemic effects of triterpenoid enriched Eugenia jambolana Lam. berry extract.  Journal of Functional Foods, 2017, 28, 1-10.
  76. Bin Muhsinah A.; Ma, H.; DaSilva, N.; Yuan, T.; Seeram, N.P. Bioactive glucitol-core containing gallotannins and other phytochemicals from silver maple (Acer saccharinum) leaves. Natural Products Communications, 2017, 12, 83-84.
  77. Liu, S.; Huang, D.; Morris-Natschke, S.; Ma, H.; Liu, Z.; Seeram, N.P.; Xu, J.; Lee, K-H; Gu, Q. Euphomilones A and B, ent-rosane diterpenoids with 7/5/6 and 5/7/6 skeletons from Euphorbia milii. Organic Letters, 2016, 18, 6132-6135.
  78. Luo, X.; Li, C.; Luo, P.; Lin, X.; Ma, H.; Seeram, N.P; Song, C.; Xu, J.; Gu. Q. Pterosin sesquiterpenoids from Pteris cretica as hypolipidemic agents via activating liver X receptors. Journal of Natural Products, 2016, 79, 3014-3021.
  79. Sun, J.; Ma, H.; Seeram, N.P.; Rowley, D.C. Detection of inulin, a prebiotic polysaccharide, in maple syrup. Journal of Agricultural and Food Chemistry, 2016, 64, 7142-7147.
  80. Liu, W.; Ma, H.; DaSilva, N.; Rose, K.; Johnson, S.L.; Zhang, L.; Wan, C.; Dain, J.; Seeram, N.P. Development of a neuroprotective potential algorithm for medicinal plants. Neurochemistry International, 2016, 100, 164-177.
  81. Mellado-Mojica, E.; Seeram, N.P.; Lopez, M.G. Comparative analysis of maple syrups and natural sweeteners: Carbohydrates composition and classification (differentiation) by HPAEC-PAD and FTIR spectroscopy-chemometrics, Journal of Food Composition and Analysis, 2016, 52, 1-8.
  82. Ma, H.; DaSilva, N.; Liu, W.; Nahar, P.P., Wei, Z.; Liu, Y.; Pham, P.T.; Crews, R.; Vattem, D.A.; Slitt, A.L.; Shaikh, Z.; Seeram, N.P. Effects of a standardized phenolic-enriched maple syrup extract on b-amyloid aggregation, neuroinflammation in microglial and neuronal cells, and b-amyloid induced neurotoxicity in Caenorhabditis elegans, Neurochemical Research, 2016, 41, 2836-2847.
  83. Beckford, F.A.; Brock, A.; Gonzalez-Sarrias, A.; Seeram, N.P. Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules, Journal of Molecular Structure, 2016, 1121, 156-166.
  84. Liu, Y.; Ma, H.; Seeram, N.P. Development and UFLC-MS/MS characterization of a product specific standard for phenolic quantification of maple food products.  Journal of Agricultural and Food Chemistry, 2016, 64, 3311-3317.
  85. Beckford, F.A.; Stott, A.; Mbarushimana, P.C.; LeBlanc, M.A.; Hall, K.; Smith, S.; Bullock, J.L.; Houghton, D.J.; Holder, A.A.; Gerasimchuk, N.N.; Gonzalez-Sarrias, A.; Seeram, N.P. Anticancer, biophysical, and computational investigations of
    half-sandwich ruthenium(II) complexes: The effect of arene versus thiacrown face-cap. Interdisciplinary Journal of Chemistry, 2016, 1, 1-15.
  86. Ma, H.; Liu, W.; Frost, L.; Kirshenbaum, L.; Dain, J.; Seeram, N.P. Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential, Food and Function, 2016, 7, 2213-2222.
  87. Kresty, L.; Fromkes, J.; Frankel, W.; Hammond, C.D.; Seeram, N.P.; Baird, M.; Stoner, G.D. A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett’s esophagus. Oncotarget, 2016, DOI: 10.18632/oncotarget.10457.
  88. Sun, J.D.; Ma, H.; Liu, W.; Marais, J.; Khoo, C.; Dain, J.; Rowley, D.C.; Seeram, N.P. Effect of cranberry (Vaccinum macrocarpon) oligosaccharides on the formation of advanced glycation endproducts, Journal of Berry Research, 2016, 6, 149-158.
  89. Skrip, M.M.; Seeram, N.P.; Yuan, T.; Ma, H.; McWilliams, S.R. Dietary antioxidants and flight exercise affect how female birds allocate nutrients to eggs: how carry-over effects work, Journal of Experimental Biology, 2016, 219, 2716-2725.
  90. Chen, J.; Sun, J.D.; Deering, R.D.; DaSilva, N.; Seeram, N.P.; Wang, H.; Rowley, D.C.; Rhizoleucinoside, a rhamnolipid-amino alcohol hybrid from the rhizobial symbiont Bradyrhizobium sp. BTAi1. Organic Letters, 2016, 18, 1490-1493.
  91. Gray, J.; Burgos, D.Z.; Yuan, T.; Seeram, N.; Rebar, R.; Follmer, R.; Heart, E. Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA. AJP-Endocrinology and Metabolism, 2016, 310, E394-E404.
  92. Sandhaus, S.; Taylor, T.; Edwards, T.; Huddlestown, A.; Wooten, Y.; Venkatraman, R.; Weber, R.T.; Gonzalez-Sarrias, A.; Martin, P.M.; Cagle, P.; Tse-Dinh, Y-C.; Beebe, S.J.; Seeram, N.; Holder, A.A. A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIa. Inorganic Chemistry Communications, 2016, 64, 45-49.
  93. Deering, R.W.; Chen, J.; Sun, J.; Ma, H.; Dubert, J.; Barja, J.L.; Seeram, N.P.; Wang, H.; Rowley, D.C. N-acyl dehydrotyrosines, tyrosine inhibitors from the marine bacterium, Thalassotalea sp. PP2-459. Journal of Natural Products, 2016, 79, 447-450.
  94. Yuan, T.; Ma, H.; Liu, W.; Niesen, D.B.; Shah, N.; Crews, R.; Rose, K.N.; Vattem, D.A.; Seeram, N.P. Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chemical Neurosciences, 2016, 7, 26-33.
  95. Ma, H.; Wang, L.; Niesen, D.B.; Cai, A.; Cho, B.P.; Tan, W.; Gu, Q.; Xu, J.; Seeram, N.P. Structure activity related, mechanistic and modeling studies of gallotannins containing a glucitol core and a-glucosidase. RSC Advances, 2015, 5, 107904-107915.
  96. Zhang, Y.; Ma, H.; Liu, W.; Yuan, T.; Seeram, N.P. New antiglycative compounds from cumin (Cuminum cyminum) spice. Journal of Agricultural and Food Chemistry, 2015, 63, 10097-10102.
  97. Kapoor, R.; Ronnenberg, A.; Puleo, E.; Chatterton Jr., R.T.; Dorgan, J.F.; Seeram, N.P.; Sturgeon, S.R. Effects of pomegranate juice on hormonal biomarkers of breast cancer risk. Nutrition and Cancer, 2015, DOI:10.1080/01635581.2015.1073756.
  98. Zhang, L.; Tu, Z-C.; Yuan, T.; Ma, H.; Niesen, D.B.; Wang, H.; Seeram, N.P. New gallotannin and other phytochemicals from sycamore maple (Acer pseudoplatanus) leaves. Natural Products Communications, 2015, 10, 1977-1980.
  99. Zhang, Y.; Ma, H.; Yuan, T.; Seeram, N.P. Red maple (Acer rubrum) aerial parts as a source of bioactive phenolics. Natural Products Communications, 2015, 10, 1409-1412.
  100. Sun, J.; Marais, J.; Khoo, C.; LaPlante, K.; Givskov, M.; Tolker-Nielsen, T.; Vejborg, R.M.;  Seeram, N.P.; Rowley, D.C. Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Eschericha coli. Journal of Functional Foods, 2015, 17, 235-242.
  101. Orr, K.K.; Feret, B.M.; Lemay, V.A.; Cohen, L.B.; MacDonnell, C.P.; Seeram, N.; Hume, A.L. Assessment of a hybrid team based learning (TBL) in a required self-care course. Currents in Pharmacy Teaching and Learning, 2015, http://dx.doi.org/10.1016/j.cptl.2015.04.016.
  102. Nahar, P.; Slitt, A.; Seeram, N.P. Anti-inflammatory effects of novel standardized solid lipid curcumin formulations. Journal of Medicinal Food, 2015, 18, 786-792.
  103. Ma, H.; Liu, W.; Frost, L.; Wang, L.; Kong, L.; Dain, J.A.; Seeram, N.P. The hydrolyzable gallotannin, penta-O-galloyl-b-D-glucopyranoside inhibits the formation of advanced glycation endproducts by protecting protein structure. Molecular BioSystems, 2015, 11, 1338-1347.
  104. Niesen, D.B.; Ma, H.; Yuan, T.; Bach II, A.C.; Henry, G.E.; Seeram, N.P. Phenolic constituents of Carex vulpinoidea seeds and their tyrosinase inhibitory activities. Natural Products Communications, 2015, 3, 491-493.
  105. Yuan, T.; Nahar, P.; Sharma, M.; Liu, K.; Slitt, A.; Aisa, H.A.; Seeram, N.P. Indazole-type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro. Journal of Natural Products, 2014, 77, 2316-2320.
  106. Ahmed, A.H.; Subaiea, G.M.; Eid, A.; Li, L.; Seeram, N.P.; Zawia, N.H. Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer’s disease animal model. Current Alzheimer Research, 2014, 11, 834-843.
  107. Liu, W.; Ma, H.; Frost, L.; Yuan, T.; Dain, J.A.; Seeram, N.P. Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species. Food and Function, 2014, 5, 2996-3004.
  108. Zhang, Y.; Yuan, T.; Li, L.; Nahar, P.; Slitt, A.; Seeram, N.P. Chemical compositional, biological, and safety studies of a novel maple syrup derived extract for nutraceutical applications. Journal of Agricultural and Food Chemistry, 2014, 62, 6687-6698.
  109. Kumar, K.; Schniper, S.; González-Sarrías, A.; Holder, A.A.; Sanders, N.; Sullivan, D.; Jarrett, W.L.; Davis, K.; Bai, F.; Seeram, N.P.; Kumar, V. Highly potent anti-proliferative effects of a gallium (III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation. European Journal of Medicinal Chemistry, 2014, 86, 81-86.
  110. Nahar, P.; Driscoll, M.; Li, L.; Slitt, A.L.; Seeram, N.P. Phenolic mediated anti-inflammatory effects of a maple syrup extract against RAW264.7 macrophages. Journal of Functional Foods, 2014, 6, 126-136.
  111. Guo, L.; Panderi,  I.; Yan, D.D.; Szulak, K.; Li, Y.; Chen, Y.T.; Ma, H.; Niesen, D.B.; Seeram, N.; Ahmed, A.; Yan, B.; Pantazatos, D.;  Lu, W. A comparative study of hollow copper sulfide nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. 2013, 7, 8780-8793.
  112. Yuan, T.; Wan, C.; Ma, H.; Seeram, N.P. Novel phenolics from the flowers of Punica granatum and their α-glucosidase inhibitory activities, Planta Medica, 2013, 79, 1-6.
  113. Pericherla, K.; Shirazi, A.N.; Rao, V.K.; Tiwari, R.; DaSilva, N.; Mccaffrey, K.T.; Beni, Y.A.; González-Sarrías, A.; Seeram, N.P.; Parang, K.; Kumar, A. Synthesis and antiproliferative activities of quebecol and its analogs.  Bioorganic Medicinal Chemistry Letters, 2013, 23, 5329-5331.
  114. Yuan, T.; Li, L.; Zhang, Y.; Seeram, N.P. Pasteurized and sterilized maple sap as functional beverages: Chemical composition and antioxidant activities. Journal of Functional Foods, 2013, 5, 1582-1590.
  115. Jean-Gilles, D.; Li, L.; Vaidyanathan, V.G.; King, R.; Cho, B.; Worthen, D.R.; Chichester, C.O.; Seeram, N.P. Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo. Chemico-Biological Interactions, 2013, 205, 90-99.
  116. Beckford, F.; Brock, A.; González-Sarrías, A.; Seeram, N.P. Novel microwave synthesis of half-sandwich [(h6-C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity. Applied Organometallic Chemistry, 2013, 27, 425-434.
  117. Bolser, J.A.; Alan, R.R.; Smith, A.D.; Li, L.; Seeram, N.P.; McWilliams, S.R. Birds select fruits with more anthocyanins and phenolic compounds during autumn migration, Wilson Journal of Ornithology, 2013, 125, 97-108.
  118. González-Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S- and G2/M-cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels. Food Chemistry, 2013, 136, 636-642.
  119. Woode, D.R.; Aiyer, H.S.; Sie, N.; Zwart, A.L.; Li, L.; Seeram, N.P.; Clarke, R. Effect of berry extracts on fulvestrant (ICI 182,780) sensitive and resistant cell lines, International Journal of Breast Cancer, 2012, doi:10.1155/2012/147828; Epub article; 11 pages.
  120. Tao, Y.; Ding, Y.; Wan, C.; Li, L.; Xu, J.; Liu, K.; Slitt, A.; Ferreira, D.; Khan, I.A.; Seeram, N.P. Antidiabetic ellagitannins from pomegranate flowers: Inhibition of a-glucosidase and lipogenic gene expression. Organic Letters, 2012, 14, 5358-61.
  121. Seeram, N.P.; Xu, J.; Li, L.; Slitt, A. Mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes. Medicine and Health Rhode Island, 2012, 95, 283-284.
  122. Omar, R.; Li, L.; Tao, Y.; Seeram, N.P. a-Glucosidase inhibitory hydrolyzable tannins from Eugenia jambolana seeds. Journal of Natural Products, 2012, 75, 1505-1509.
  123. Wan, C.; Yuan, T.; Cirello, A.; Seeram, N.P. Antioxidant and a-glucosidase inhibitory phenolics from highbush blueberry flowers. Food Chemistry, 2012, 135, 1929-1937.
  124. Apostolidis, E.; Li, L.; Kang, B.; Lee, C.M.; Seeram, N.P. Seasonal influence on phenolic-mediated antihyperglycemic properties of Canadian sugar and red maple leaves using in vitro assay models. Food Science and Biotechnology, 2012, 3, 753-760.
  125. González-Sarrías, A.; Tao, Y.; Seeram, N.P. Cytotoxicity and structure activity relationship studies of maplexins A-I, gallotannins from red maple (Acer rubrum). Food and Chemical Toxicology, 2012, 50, 1369-1376.
  126. Wan, C.; Yuan, T.; Xie, M.; Seeram, N.P. Acer rubrum phenolics include A-type procyanidins and a chalcone. Biochemical Systematics and Ecology, 2012, 44, 1-3.
  127. Ma, H.; Tao, Y.; González-Sarrías, A.; Li, L.; Edmonds, M.E.; Seeram, N.P. New galloyl derivative from winged sumac (Rhus copallinum) fruit. Natural Products Communications, 2012, 7, 45-46.
  128. Laplante, K.L.; Sarkisian, S.A.; Woodmansee, S.; Rowley, D.C.; Seeram, N.P. Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. Phytotherapy Research, 2012, 26, 1371-1374.
  129. Jean-Gilles, D.; Li, L.; Ma, H.; Yuan, T.; Chichester, C.O.; Seeram, N.P. Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. Journal of Agricultural and Food Chemistry, 2012, 60, 5755-5762.
  130. Lewis, N.A.; Liu, F.; Seymour, L.; Magnusen, T.; Erves, T.; Arca, F.A.; Beckford, F.A.; Venkatraman, R.; González-Sarrías, A.; Fronczek, F.R.; VanDerveer, D.G.; Seeram, N.P.; Liu, A.; Jarrett, W.L.; Holder, A.A. Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a schiff base and thiosemicarbazones as mixed-ligands. European Journal of Inorganic Chemistry, 2012, 4, 664-677.
  131. Yuan, T.; Wan, C.; Liu, K.; Seeram, N.P. New maplexins F-I and phenolic glycosides from red maple (Acer rubrum) bark. Tetrahedron, 2012, 68, 959-964.
  132. Wan, C.; Yuan, T.; Li, L.; Kandhi, V.; Cech, N.B.; Xie, M.; Seeram, N.P. Maplexins, new a-glucosidase inhibitors from red maple (Acer rubrum) stems. Bioorganic Medicinal Chemistry Letters, 2012, 22, 597-600.
  133. Beckford, F.; Thessing, J.; Stott, A.; Holder, A. A.; Poluektov, O.G.; Li, L.; Seeram, N.P. Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides. Inorganic Chemistry Communications, 2012, 15, 225-229.
  134. González-Sarrías, A.; Li, L.; Seeram, N.P. Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells. Journal of Functional Foods, 2012, 4, 185-196.
  135. Donepudi, A.C.; Goedken, M.J.; Aleksunes, L.M.; Seeram, N.P.; Slitt, A. The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit) decreases liver inflammation, injury and fibrosis during cholestasis. Liver International, 2012, 32, 560-573.
  136. González-Sarrías, A.; Li, L.; Seeram, N.P. Effects of maple (Acer) plant part extracts on proliferation, apoptosis, and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells. Phytotherapy Research, 2012, 26, 995-1002.
  137. LeBlanc, M-A.; Gonzales-Sarrias, A.; Beckford, F.; Mbarushimana, P.C.; Seeram, N.P. Coordination chemistry of polyaromatic thiosemicarbazones. 2: Synthesis and biological activity of zinc, cobalt and copper complexes of 1-(naphthalene-2-yl)ethanone thiosemicarbazone. International Journal of Inorganic Chemistry, 2011, accepted. doi:10.1155/2011/624756.
  138. Apostolidis, E.; Karayannakidis, P.D.; Kwon, Y-I.; Lee, C.M.; Seeram, N.P.  Seasonal variation of phenolic antioxidant-mediated a-glucosidase inhibition of Ascophyllum nodosum. Plant Foods for Human Nutrition, 2011, 66, 313-319.
  139. Yuan, T.; Wan, C.; González-Sarrías, A.; Kandhi, V.; Cech, N.B.; Seeram, N.P. Phenolic glycosides from sugar maple (Acer saccharum) bark. Journal of Natural Products, 2011, 74, 2472-2476.
  140. González-Sarrías, A.; Gromek, S.; Niesen, D.; Seeram, N.P.; Henry, G.E. Resveratrol oligomers isolated from Carex species inhibit proliferation of human colon tumorigenic cells inhibited by cell cycle arrest. Journal of Agricultural and Food Chemistry, 2011, 59, 8632-8638.
  141. Ponnala, S.; Chaudhary, S.; González-Sarrías, A.; Seeram, N.P.; Harding, W.W. Cytotoxicity of aporphines in human colon cancer cell lines, HCT-116 and Caco-2: an SAR study. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 4462-4464.
  142. Li, L.; Seeram, N.P. Further investigation into maple syrup yields three new lignans, a new phenylpropanoid, and twenty-six other phytochemicals. Journal of Agricultural and Food Chemistry, 2011, 59, 7708-7716.
  143. Henning, S.M.; Zhang, Y.; Seeram, N.P.; Bowerman, S.; Heber, D. Antioxidant capacity of herbs in dried, fresh, and blended paste forms. International Journal of Food Science and Nutrition, 2011, 62, 219-225.
  144. Beckford, F.A.; Thessing, J.; Shaloski, M.; Mbarushimana, P.C.; Brock, A.; Didion, J.; Woods, J.; González-Sarrías, A.; Seeram, N.P. Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents. Journal of Molecular Structure, 2011, 992, 39-47.
  145. Beckford, F. A.; Thessing, J.; Woods, J.; Didion, J.; Gerasimchuk, N.; González-Sarrías, A.; Seeram, N.P. Synthesis and structure of [(η6–p-cymene)Ru(2-anthracen-9 ylmethylene-N-ethylhydrazinecarbothioamide)Cl]Cl: Biological evaluation, topoisomerase-II inhibition and reaction with DNA and human serum albumin. Metallomics, 2011, 3, 491-502.
  146. Beckford, F.A.; Shaloski, M.; Thessing, J.; Woods, J.; Dourth, D.; Didion, J.; Gerasimchuk, N.;  González-Sarrías, A.; Seeram, N.P. Half-sandwich ruthenium-arene complexes with thiosemicarbazones: Synthesis and biological evaluation of [(n6–p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl. Journal of Inorganic Biochemistry, 2011, 105, 1019-1029.
  147. Apostolidis, E.; Li, L.; Lee, C.M.; Seeram, N.P. In vitro evaluation of phenolic-enriched extracts of maple syrup for inhibition of carbohydrate hydrolyzing enzymes relevant to type 2 diabetes. Journal of Functional Foods, 2011, 3, 100-106.
  148. Li, L.; Seeram, N.P. Quebecol, a novel phenolic compound isolated from Canadian maple syrup. Journal of Functional Foods, 2011, 3, 125-128.
  149. Hong, M-Y.; Henning, S.M.; Moro, A.; Seeram, N.P.; Zhang, Y.; Heber, D. Chinese Red Yeast Rice inhibition of prostate tumor growth in SCID mice. Cancer Prevention Research, 2011, 4, 608-615.
  150. Manning, K.; Petrunak, E.; Lebo, M.; González-Sarrías, A.; Seeram, N.P.; Henry, G.E. Acylphloroglucinols and xanthones from Hypericum ellipticum.  Phytochemistry, 2011, 72, 662-667.
  151. Ma, H.; Li, L.; Seeram, N.P. Phenolics from Cornus amomum Mill. fruit. Biochemical Systematics and Ecology, 2010, 38, 1083-1084.
  152. Li, L.; Woolridge, D.; Saing, S.R.; Jennings, J.; Henry, G.E.; Seeram, N.P. Flavonoids and a stilbene from Triadenum fraseri (Spach) Gleason.  Biochemical Systematics and Ecology, 2010, 38, 1074-1076.
  153. Li, L.; Seeram, N.P. Maple syrup phytochemicals include lignans, coumarins, a stilbene and other previously unreported antioxidant phenolic compounds. Journal of Agricultural and Food Chemistry, 2010, 58, 11673-11679.
  154. Zunino, S.; Zhang, Y.; Seeram, N.P.; Storms, D.  Berry fruit extracts inhibit growth and induce apoptosis of high risk acute lymphoblastic leukemia cells in vitro. Journal of Functional Foods, 2010, 2, 185-195.
  155. Adams, L.S.; Phung, S.; Yee, N.; Seeram, N.P.; Li, L.; Chen, S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol-3-kinase pathway. Cancer Research, 2010, 70, 3594-605.
  156. Sharma, M.; Li, L.; Celver, J.; Killian, C.; Kovoor, A.; Seeram, N.P. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. Journal of Agricultural and Food Chemistry, 2010, 58, 3965-3969.
  157. Koyama, S.; Cobb, L.J.; Mehta, H.H.; Seeram, N.P.; Heber, D.; Pantuck, A.J.; Cohen P. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Hormone IGF Research, 2010, 20, 55-62.
  158. Adams, L.S.; Zhang, Y.; Seeram, N.P.; Heber, D.; Chen. S. Pomegranate ellagitannin derived compounds exhibit anti-proliferative and anti-aromatase activities in breast cancer cells in vitro. Cancer Prevention Research, 2010, 3,108-113.
  159. Henning, S.M.; Seeram, N.P.; Zhang, Y.; Li, L.; Gao, K.; Lee, R.; Wang, D.C.; Zerlin, A.; Karp, H.; Thames, G.; Kotlerman, J.; Li, Z.; Heber, D. Strawberry consumption is associated with increased antioxidant capacity in serum.  Journal of Medicinal Foods, 2010, 13, 116-122.
  160. Beckford, F.; Leblanc, G.; Thessing, J.; Shaloski, M.; Frost, B.J.; Li, L.; Seeram, N.P. Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(6-p-cymene)Ru(NS)Cl]+ (NS = 9-anthraldehyde thiosemicarbazones).  Inorganic Chemistry Communications, 2009, 12, 1094-1098
  161. Beckford, F.; Shaloski, M.; Leblanc, G.; Thessing, J.; Lewis -Alleyne, L.C.; Holder,A. A.; Li, L.; Seeram, N.P. Microwave synthesis of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity. Dalton Transactions, 2009, 48, 10757-10764.
  162. Henry, G.E.; Campbell, M.; Zelinsky, A.A.; Liu, Y.; Bowen-Forbes, C.S.; Li, L.; Nair, M.G.; Rowley, D.C.; Seeram, N.P. Bioactive acylphloroglucinols from Hypericum densiflorum. Phytotherapy Research, 2009, 23, 1759-1762.
  163. Li, L.; Henry G.E.; Seeram, N.P. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds.  Journal of Agricultural and Food Chemistry, 2009, 57, 7282-7287.
  164. Zunino, S.J.; Storms, D.H.; Zhang, Y.; Seeram, N.P. Growth arrest and induction of apoptosis in high-risk leukemia cells by strawberry components. Journal of Functional Foods, 2009, 1, 153-160.
  165. Zhang, Y.; Krueger, D.; Durst, R.; Lee, R.; Wang, D.; Seeram, N.P.; Heber, D. International Multidimensional Authenticity Specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration. Journal of Agricultural and Food Chemistry, 2009, 57, 2550-2557.
  166. Li, L.; Zhang, Y.; Seeram, N.P. Structure of anthocyanins from Eugenia jambolana fruit.  Natural Products Communications, 2009, 4, 217-219.
  167. Li, L.; Adams, L.S.; Chen, S.; Killian, C.; Ahmed, A.; Seeram, N.P. Eugenia jambolana  Lam. berry extract inhibits proliferation and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. Journal of Agricultural and Food Chemistry, 2009, 57,826-831.
  168. Sathe, S.K.; Seeram, N.P.; Kshirsagar H.H.; Heber, D.; Lapsley, K.A. Fatty acid composition of California grown almonds. Journal of Food Sciences, 2008, 73, C607-14.
  169. Hong, M.Y.; Seeram, N.P.; Zhang, Y.; Heber, D. Chinese Red Yeast Rice vs. Lovastatin effects on prostate cancer cells with and without androgen receptor overexpression.  Journal of Medicinal Foods, 2008, 11, 657-666.
  170. Hong, M.Y.; Seeram, N.P.; Heber, D. Pomegranate polyphenols downregulate expression of androgen synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. Journal of Nutritional Biochemistry, 2008, 19, 848-55.
  171. Hong, M.Y.; Seeram, N.P.; Zhang, Y.; Heber, D. Anticancer effects of Chinese Red Yeast Rice versus monacolin alone on colon cancer cells. Journal of Nutritional Biochemistry, 2008, 19, 448-458.
  172. Rettig, M.B.; Heber, D.; An, J.; Seeram, N.P.; Liu, H.; Rao, J.Y.; Liu, H.; Klatte, T.; Belldegrun, A.; Moro, A.; Henning, S.M.; Mo, D.; Aronson, W.J.; Pantuck, A.J. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-Kb-dependent mechanism. Molecular Cancer Therapeutics, 2008, 7, 2662-2671.
  173. Seeram, N.P.; Zhang, Y.; McKeever, R.; Henning, S.M.; Lee, R.; Sartippour, M.; Suchard, M.A.; Li, Z.; Chen, S.; Thames, G.; Zerlin, A.; Nguyen, M.; Wong, D. Heber, D. Ellagitannin metabolites are present in human plasma and urine in similar levels after consumption of pomegranate fruit juice and its liquid and solid extracts. Journal of Medicinal Foods, 2008, 11, 390-394.
  174. Seeram, N.P.; Aviram M.; Zhang, Y.; Henning, S.M.; Dreher, M.; Heber, D. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. Journal of Agricultural and Food Chemistry, 2008, 56, 1415-1422. (Most accessed article for year 2008 in the Journal of Agricultural and Food Chemistry).
  175. Zhang, Y.; Seeram, N.P.; Lee, R.; Feng, L.; Heber, D. Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative activities. Journal of Agricultural and Food Chemistry, 2008, 56, 670-675.  (Most accessed article for Jan-Mar 2008 in the Journal of Agricultural and Food Chemistry).
  176. Sartippour, M.; Seeram, N.P.; Rao, J.Y.; Moro, A.; Harris, D.M.; Firozi, A.; Rettig, M.; Aronson, W.J.; Pantuck, A.J.; Heber, D. Ellagitannin-rich pomegranate extract inhibit angiogenesis in prostate cancer in vitro and in vivo. International Journal of Oncology, 2008, 32, 475-80.
  177. Venkatachalam, M.; Kshirsagar H.H.; Seeram, N.P.; Heber, D.; Thompson, T.T.; Roux, K.H.; Sathe, S.K. Biochemical composition and immunological comparison of select pecan [Carya illinoinensis (Wangenh.) K. Koch] cultivars. Journal of Agricultural and Food Chemistry, 2007, 55, 9899-07.
  178. Heber, D.; Seeram, N.P; Wyatt, H.; Henning, S.M.; Zhang, Y.; Ogden, L.G.; Dreher, M.; Hill, J.O. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol extract dietary supplement in overweight individuals with increased waist size. Journal of Agricultural and Food Chemistry, 2007, 55, 10050-10054.
  179. Seeram, N.P.; Aronson, W.J.; Zhang, Y.; Henning, S.M.; Moro, A.; Lee, R.; Sartippour, M.; Harris, D.M.; Rettig, M.B.; Suchard, M.A.; Pantuck, A.J.; Belldegrun, A.; Heber, D. Pomegranate ellagitannin derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. Journal of Agricultural and Food Chemistry, 2007, 55, 7777-7785. (Most accessed article for Oct-Dec 2007 in the Journal of Agricultural and Food Chemistry)
  180. Bobe, G.; Wang, B.; Seeram, N.P.; Nair, M.G.; Bourquin. L.D.   Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APCMin mice fed suboptimal levels of sulindac.  Journal of Agricultural and Food Chemistry 2006, 54, 9322-9328.
  181. Seeram, N.P.; Adams, L.S; Zhang, Y; Sand, D.; Heber, D. Blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. Journal of Agricultural and Food Chemistry, 2006, 54, 9329-39. (Most accessed article for Oct-Dec 2006 in the Journal of Agricultural and Food Chemistry)
  182. Li, Z.; Seeram, N.P.; Carpenter, C.; Thames, G.; Minutti, C.; Bowerman, S. Effect of cranberry on INR in subjects on warfarin for atrial fibrillation. Journal of American Dietetic Association, 2006, 106, 2057-2061.
  183. Henry, G.E.; Raithore, S.; Zhang, Y.; Jayaprakasam B.; Nair, M.G.; Heber, D.; Seeram, N.P. Acylphloroglucinol derivatives from Hypericum prolificum. Journal of Natural Products, 2006, 69, 1645-1648.
  184. Henry, G.E.; Adams, L.S.; Rosales, J.C.; Jacobs, H.; Heber, D.; Seeram, N.P. Kaurene  diterpenes from Laetia thamnia inhibit the growth of human cancer cell lines in vitro.   Cancer Letters, 2006, 244, 190-194.
  185. Seeram, N.P.; Henning, S.M.; Zhang, Y.; Suchard, M.; Li, Z.; Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. Journal of Nutrition, 2006,136, 2481-2485.
  186. Seeram, N.P.; Zhang, Y.; Henning, S.M.; Lee, R.; Niu, Y.; Lin, G.; Heber D. Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative properties. Journal of Agricultural and Food Chemistry, 2006, 54, 7036-7040.
  187. Kobayashi, N.; Barnard, R.J.; Henning, S.H.; Elashoff, D.; Reddy, S.T.; Cohen, P.; Leung, P.; Hong-Gonzalez, J.; Freedland, S.J.; Said, J.; Gui, D.; Seeram, N.P.; Popoviciu, L.M.; Bagga, D.; Heber, D.; Glaspy, J.A.; Aronson, W.J. Effect of altering dietary omega-6: omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2 and prostaglandin E-2. Clinical Cancer Research, 2006, 12, 4662-4670.
  188. Sarafian, T.; Habib, N.; Oldham, M.; Seeram, N.P.; Lee, R.; Tashkin, D.P.; Roth, M.D. Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006, 290, L1202-209.
  189. Muller, C.I.; Kumagai T.; Kelly, J.O.; Seeram, N.P.; Heber, D.; Koeffler, P.H. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leukemia Research, 2006, 30, 841-848.
  190. Pantuck, A.J.; Leppert, J.T.; Zomorodian, N.; Aronson, W.; Hong, J.; Barnard, R.J.; Seeram, N.P.; Liker, H.; Wang, H-E.; Elashoff, R.; Heber, D.; Aviram, M.; Ignarro, L.;  Belldegrun, A. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clinical Cancer Research, 2006, 12, 4018-4026.
  191. Henning, S.M.; Aronson, W.; Niu, Y.; Conde, F.; Lee, N.H.; Seeram, N.P.; Lee, R.; Lu, J.; Harris, D.M.; Moro, A.; Hong, J.; Pak-Shan, L.; Barnard, R.J.; Ziaee, H.G.; Csathy, G.; Go, V.L.W.; Wang, H.; Heber, D. Bioavailability and bioactivity of tea polyphenols in human and mice prostate tissue and serum after green and black tea consumption. Journal of Nutrition, 2006, 136, 1839-1843.
  192. Seeram, N.P.; Henning S.M.; Lee, R.; Niu Y.; Scheuller, H.S.; Heber, D. Catechin and caffeine contents of green tea dietary supplements and correlation with antioxidant activity. Journal of Agricultural and Food Chemistry, 2006, 54, 1599-1603. (Most accessed article for year 2006 in the Journal of Agricultural and Food Chemistry).
  193. Adams, L.S.; Seeram, N.P.; Hardy, M.L.; Carpenter, C.; Heber, D. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cells. Evidence-Based Complementary and Alternative Medicine, 2006, 3, 117-124.
  194. Adams, L.S.; Seeram, N.P.; Aggarwal, B.B.; Takada, Y.; Sand, D.; Heber, D. Pomegranate juice, total pomegranate tannins and punicalagin suppress inflammatory cell signaling in colon cancer cells. Journal of Agricultural and Food Chemistry, 2006, 54, 980-985. [Cited as ACS (American Chemical Society) Hot Papers: May 2007; As defined by Thomson ISI®’s Essential Science Indicators, Hot Papers are articles published within the last 2 years receiving the most citations over the most recent 2-month period].
  195. Gao, K.; Xu, A.; Krull, C.; Venema, K.; Liu, Y.; Niu Y.; Lu, J.; Bensoussan, L.; Seeram, N.P.; Heber D.; Henning S.M. Of the major phenolic acids formed during human microbial fermentation of tea, citrus and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity. Journal of Nutrition, 2006, 136, 52-57.
  196. Gao, K.; Henning, S.M.; Niu, Y.; Bensoussan, L.; Seeram, N.P.; Xu. A.; Heber, D. The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. Journal of Nutritional Biochemistry, 2006, 17, 89-95.
  197. Seeram, N.P.; Lee, R.; Scheuller, H.S.; Heber, D. Identification of phenolics in strawberries by liquid chromatography electrospray ionization mass spectroscopy. Food Chemistry, 2006, 97, 1-11.
  198. Li, Z.; Seeram, N.P.; Lee, R.; Thames, G.; Minutti, C.; Wang, H-J.; Heber, D. Plasma clearance of Lovastatin vs. Chinese Red Yeast Rice in healthy volunteers. Journal of Alternative and Complementary Medicine, 2005, 11, 1031-1038.
  199. Loren, D.; Seeram, N.P.; Schulman, R.N.; Holtzman, D. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatric Research, 2005, 57, 858-864.
  200. Seeram, N.P.; Adams, L.S.; Henning, S.M.; Niu, Y.; Zhang, Y.; Nair, M.G.; Heber, D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. Journal of Nutritional Biochemistry, 2005,16, 360-367.
  201. Seeram, N.P.; Lee, R.; Hardy, M.L.; Heber, D. Rapid large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Separation and Purification Technology, 2005, 41, 49-55.
  202. Sartippour, M.R.; Seeram, N.P.; Heber, D.; Hardy, M.L.; Norris, N.; Lu, Q.L.; Zhang L.; Rao, J.Y.; Brooks, M.N. Rabdosia rubescens inhibits breast cancer growth and angiogenesis. International Journal of Oncology, 2005, 26, 121-127.
  203. Seeram, N.P.; Lee, R.; Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta, 2004, 348, 63-68.
  204. Tall, J.M.; Seeram, N.P.; Zhao, C.; Nair, M.G.; Meyer, R.A.; Raja, S.N. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behavioral Brain Research, 2004, 153, 181-88.
  205. Seeram, N.P.; Adams, L.S.; Hardy, M.L.; Heber, D. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. Journal of Agricultural and Food Chemistry, 2004, 52, 2512-2517.
  206. Beckwith, A.G.; Zhang, Y.; Seeram, N.P.; Cameron, A.C.; Nair, M.G. Relationship of light quantity and anthocyanin production in Pennisetum setaceum Cvs. Rubrum and Red Riding Hood. Journal of Agricultural and Food Chemistry, 2004, 52, 456-461.
  207. Zhang, Y.; Bolleddula, J.; Seeram, N.P.; Olsen, L.K.; Dewitt, D.; Nair, M.G. Insulin secretion and cyclooxygenase enzyme inhibition by Cabernet Sauvignon grape skin compounds. Journal of Agricultural and Food Chemistry, 2004, 52, 228-233.
  208. Cichewicz, R.H.; Zhang, Y.; Seeram, N.P.; Nair, M.G. Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies.  Life Sciences, 2004, 74, 1791-1799.
  209. Bolleddula, J.; Zhang, Y.; Seeram, N.P.; Nair, M.G. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life Sciences, 2003, 174, 125-132.
  210. Kang, S.Y.; Seeram, N.P.; Nair, M.G.; Bourquin, L.D. Tart cherry anthocyanins inhibit tumor development in ApcMin mice and reduce proliferation of human colon cancer cells. Cancer Letters, 2003, 194, 13-19.
  211. Seeram, N.P.; Zhang, Y.; Nair, M.G. Inhibition of proliferation of human cancer cell lines and cyclooxygenase enzymes by anthocyanidins and catechins. Nutrition and Cancer, 2003, 46, 101-106.
  212. Seeram, N.P.; Cichewicz, R.H.; Chandra, A.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. Journal of Agricultural and Food Chemistry, 2003, 51, 1948-1951.
  213. Bolleddula, J.; Seeram, N.P.; Nair, M.G. Anticancer and anti-inflammatory activities of        cucurbitacins from Cucurbita andreana. Cancer Letters, 2003, 189, 11-16.
  214. Seeram, N.P.; Francis, L.S.; Needham, O.L.; Jacobs, H.; McLean, S.; Reynolds, W.F. Drimane and bisabolane sesquiterpenoids from Cinnamodendron corticosum  (Canellaceae). Biochemical Systematics and Ecology, 2002, 31, 637-640.
  215. Seeram, N.P.; Nair, M.G. Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents, anthocyanins, anthocyanidins and catechins. Journal of Agricultural and Food Chemistry, 2002, 50, 5308-5312.
  216. Seeram, N.P.; Schutzki, R.; Chandra, A.; Nair, M.G. Characterization, quantification and bioactivities of anthocyanins in Cornus species. Journal of Agricultural and Food Chemistry, 2002, 50, 2519-2523.
  217. Seeram, N.P.; Bourquin, L.D.; Nair, M.G. Degradation products of cyanidin glycosides from tart cherries and their bioactivities. Journal of Agricultural and Food Chemistry, 2001, 49, 4924-4929.
  218. Seeram, N.P.; Momin, R.A.; Bourquin, L.D.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides from cherries and berries. Phytomedicine, 2001, 8, 362-369.
  219. Jacobs, H.; Seeram, N.P.; Nair, M.G.; McLean, S.; Reynolds, W.F. Amides of Piper amalago var. nigrinodum. Journal of Indian Chemical Society, 2000, 76, 713-717.
  220. Seeram, N.P.; Lewis, A.; Jacobs, H.; Nair, M.G.; McLean, S.; Reynolds, W.F. Proctoriones A-C: 2-acylcyclohexane-1,3-dione derivatives from Peperomia proctorii. Journal of Natural Products, 2000, 63, 399-402.
  221. Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F. A prenylated benzopyran derivative from Peperomia clusiifolia. Phytochemistry, 1998, 49, 1389-1391.
  222. Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F. Prenylated hydroxybenzoic derivatives from Piper murrayanum. Phytochemistry, 1996, 43, 863-865.
  223. Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F.; Tay, L.; Wu, M. 3,4-epoxydihydropiplartine, A new imide from Piper verrucosum. Journal of Natural Products, 1996, 59, 436-437.

Review & Symposium Introduction Articles in Peer-Reviewed Journals

  1. Liu, C.; Seeram, N.P.; Ma, H. Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review. Cancer Cell International, 2021, 21, 239. (Invited Review).
  2. Seeram, N.P.; Burton-Freeman B.  The eighth biennial berry health benefits symposium. Food and Function, 2020, 11, 30-31.
  3. Seeram, N.P.; Burton-Freeman B.  The seventh biennial berry health benefits symposium. Food and Function, 2018, 9, 20-21.
  4. Seeram, N.P.; Shukitt-Hale, B.  Advances in berry research: The sixth biennial berry health benefits symposium. Journal of Berry Research, 2016, 16, 93-95.
  5. Seeram, N.P. Berries and human health: Research highlights from the fifth biennial berry health benefits symposium, Journal of Agricultural and Food Chemistry, 2014, 62, 3839-3841.
  6. Niesen, D.; Hessler, C.; Seeram, N.P. Beyond resveratrol: a review of natural stilbenoids identified from 2009-2013. Journal of Berry Research, 2013, 3, 181-196. (Invited Review).
  7. Seeram, N.P. Emerging research supporting the positive effects of berries on human health and disease prevention. Journal of Agricultural and Food Chemistry, 2012, 60, 5685-5686.
  8. Seeram, N.P. Recent trends and advances in berry health benefits research. Journal of Agricultural and Food Chemistry, 2010, 58, 3869-3870.
  9. Seeram, N.P. Berry Fruits: Compositional elements, biochemical activities and the impact of their intake on human health, performance and disease. Journal of Agricultural and Food Chemistry, 2008, 56, 627-629. (Most accessed article for year 2008 in the Journal of Agricultural and Food Chemistry).
  10. Seeram, N.P. Berry fruits for cancer prevention: Current status and future prospects. Journal of Agricultural and Food Chemistry, 2008, 56, 630-635. (Most accessed article for Jan-Mar 2008 in the Journal of Agricultural and Food Chemistry).
  11. Aggarwal, B.B.; Bhardwaj, A.; Aggarwal, R.S.; Seeram, N.P.; Shishodia, S.; Takada, Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research, 2004, 24, 2783-2840. (Invited Review).

Book Chapters

  1. Heber, D.; Seeram, N.P. Phytonutrients and Cancer In: Nutritional Oncology. First Edition. Heber, D.; Li, Z.; Go, V.L.W.; (Eds). CRC Press, Boca Raton2021 eBook ISBN. 2021. https://doi.org/10.1201/9780429317385. 
  2. Yuan, T.; Seeram, N.P. Pomegranate Juice, Chapter 42, pp. 513-526, In: Handbook of Functional Beverages and Human Health, Alasalvar, C.; Shahidi, F. (Eds). CRC Press, Boca Raton, FL, USA, 2016. Print ISBN: 978-1-4665-9641-2. eBook ISBN: 978-1-4665-9642-9.
  3. Yuan, T. and Seeram, N.P. Maple Water, Chapter 58, pp. 757-764, In: Handbook of Functional Beverages and Human Health, Alasalvar, C.; Shahidi, F. (Eds). CRC Press, Boca Raton, FL, USA, 2016. Print ISBN: 978-1-4665-9641-2. eBook ISBN: 978-1-4665-9642-9.
  4. Do, Q.T.; Driscoll, M.; Slitt, A.; Seeram, N.; Peppard, T.; Bernard, P. Reverse pharmacognosy: A tool to accelerate discovery of new bioactive food ingredients. In: Foodinformatics, Martinez-Mayorga, K.; Medina-Franco, J.L. (Eds), Springer International Publishing, pp.111-130, 2014. doi: 10.1007/978-3-319-10226-9_4; ISBN: 978-3-319-10225-2.
  5. Li, L.; Seeram, N.P. Chemical composition and biological effects of maple syrup. Chapter 18, pp. 323-333. American Chemical Society (ACS) Symposium Series Volume 1093, In Emerging Trends in Dietary Components for Preventing and Combating Disease, Patil, B.; Murthy, K.N.C.; Jayaprakasha, G.K.; Seeram, N.P. (Eds), Oxford University Press, Washington DC, USA, 2012.
  6. Seeram, N.P. Polyphenol overview.  In: Encyclopedia of Dietary Supplements. Coates, P.; Betz, J.M.; Blackman, M.R.; Cragg, G.M.; Levine, M.; Moss, J.; White, J.D. (Eds.). Informa Healthcare, New York, NY, USA, 2010, p.632.
  7. Seeram, N.P.; Zhang, Y.; Bowerman, S.; Heber, D. Phytochemicals and health aspects of the pistachio. In: Tree Nut Nutraceuticals, Phytochemicals, and Health Aspects. Alasalvar, C.; Shahidi, F. (Eds). CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, 2009, pp. 295-304.
  8. Seeram, N.P. Strawberry phytochemicals and human health: A review. In: Takeda, F., D.T. Handley, and E.B. Poling (Eds.). Proceedings of the 2007 North American Strawberry Symposium.  North American Strawberry Growers Association, Kemptville, ON, Canada, 2008. pp. 7-14.
  9. Seeram, N.P.; Heber, D. Impact of berry phytochemicals on human health: Effects beyond antioxidation. Chapter 21. In: Lipid Oxidation and Antioxidants: Chemistry, Methodologies and Health Effects. American Chemical Society (ACS) Symposium Series No. 956/Antioxidant Measurement and Applications; Ho, C.T; Shahidi, F.S. (Eds). Oxford University Press, UK, 2006.
  10. Aggarwal, B.B.; Bhatt, I.D.; Ichikawa, H.; Ahn, K.S.; Sethi, G.; Sandur, S.K.; Natarajan, C.; Seeram, N.P.; Shishodia, S.  Curcumin: Biological and medicinal properties. Chapter 10, pp. 297-368. In: Turmeric: The genus Curcuma. Ravindran, P.N.; Babu, K.N.; Sivaraman, K. (Eds.) CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  11. Seeram, N.P.; Zhang, Y.; Reed, J; Krueger, C.; Vaya, J. Pomegranate phytochemicals. Chapter 1, pp. 3-30. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  12. Espin, J.C.; Seeram, N.P.; Tomás-Barberán, F.A. Bioavailability of pomegranate polyphenols. Chapter 3, pp. 45-60. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  13. Harris, D.M.; Besselink, E.; Seeram, N.P. Assessment of estrogenicity of pomegranate in an in vitro bioassay. Chapter 9, pp. 143-155. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal &Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  14. Seeram, N.P.; Zhang, Y.; Heber, D. Commercialization of pomegranates: Fresh fruits, beverages and botanical extracts. Chapter 12, pp. 187-196. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal Aromatic Plant Series, Boca Raton, FL, USA, 2006.
  15. Seeram, N.P. Berries. Chapter 37, pp. 615-625. In: Nutritional Oncology. Second Edition. Heber, D.; Blackburn, G.; Go, V.L.W.; Milner, J. (Eds). Academic Press, London, UK, 2006.
  16. Seeram, N.P. Bioactive polyphenols from foods and dietary supplements: Challenges and opportunities. Chapter 3, pp. 25-38; In: Herbs: Challenges in Chemistry and Biology; ACS Symposium Series No. 925 (Herbs); Ho, C.T; Wang, M.; Sang, S. (Eds). Oxford University Press, UK, 2006.
  17. Seeram, N.P.; Kulkarni, V.V.; Padhye, S. Sources and chemistry of resveratrol. Chapter 2, p. 17. In: Oxidative Stress and Diseases Series: Resveratrol in Health and Disease. Aggarwal, B.B.; Shishodia, S.; Packer, L. (Eds). Taylor & Francis Group, Boca Raton, FL, USA, 2006.
  18. Seeram, N.P.; Ichikawa, H.; Shishodia, S.; Aggarwal, B.B. Preventative and therapeutic effects of plant polyphenols through suppression of nuclear factor-kappa B. Chapter 21, pp. 243-275. In: Oxidative Stress and Diseases Series: Molecular Intervention in Lifestyle-Related Diseases. Hiramatsu, M.; Yoshikawa, T.; Packer, L. (Eds). CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, 2006.

Book Editor & Book Series Editor

  1. Patil, B.; Murthy, K.N.C.; Jayaprakasha, G.K.; Seeram, N.P. (Eds). American Chemical Society (ACS) Symposium Series, Emerging Trends in Dietary Components for Preventing and Combating Disease, American Chemical Society, Washington DC, distributed by Oxford University Press, 2012.
  2. Stoner, G.; Seeram, N.P. (Eds). Berries and Cancer.  Springer Science, NY, USA, 2011.
  3. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). Pomegranates: Ancient Roots Modern Medicine. CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006. 
  4. Seeram, N.P. Founding Editor of Clinical Pharmacognosy Series; CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, August 2008.  Three volumes published in this series to date.

Patents

  1. Rowley, D.; Sun, J.; Deering, R.; Seeram, N.P.; Cohen P. Cranberry-derived compositions for potentiating antibiotic efficacy against bacterial persistence. US Patent No. US11369628B2, 2018.
  2. Seeram, N.P.; Ma, H.; Parang, K.  Methods for skin whitening using a gallotannin. US Patent No. 10,155,738, B2, December 18, 2018.
  3. Seeram, N.P.; Heber D. Therapeutic uses of urolithins. US Patent No. 8,648,112 B2, 2014.
  4. Seeram, N.P.; Heber D. Purifications of pomegranate ellagitannins and their uses thereof. US Patent No. 7,897,791 B2, 2011.
  5. Seeram, N.P.; Heber D. Purifications of pomegranate ellagitannins and their uses thereof. US Patent No. 7,919,636 B2, 2011.
  6. Seeram, N.P.; Heber D.  Purifications of pomegranate ellagitannins and their uses thereof. US Patent No. 7,638,640 B2, 2009.
  7. Nair, M.G.; Bourquin, L.D.; Seeram, N.P.; Kang, S.Y. Method for treating tumors caused by APC gene mutation with anthocyanins and cyanidin, US Patent No. 6,656,914 B2, 2003.
  8. Nair, M. G.; Cichewicz, R.C.; Seeram, N.P.; Zhang, Y. Anticancer anthraquinones isolation from Hemerocallis fulva and methods of use. US Patent No. 6,875,746 B1, 2005.

Honors and Awards

• Thomson Reuters Highly Cited Researcher in Agricultural Sciences for 2014-2019 (based on papers indexed in Web of Science; highlycited.com).
• 2019 Distinguished Service Award, Agricultural and Food Chemistry Division, American Chemical Society.
• 2017 International Maple Syrup Institute President’s Award
• 2017 Chair, Agricultural and Food Chemistry Division, American Chemical Society.
• 2009 Young Scientist Awardee, Agricultural and Food Chemistry Division, American Chemical Society.
• Editorial Boards: Journal of Agricultural and Food Chemistry, International Journal of Applied Research in Natural Products, Journal of Berry Research.
• Advisory Board of the American Botanical Council.
• Best Third Year Student in Natural Sciences, University of Guyana, Georgetown, Guyana.
• Best Third Year Organic Chemistry Student, University of Guyana, Georgetown, Guyana.
• Best Graduating Student in Natural Sciences, University of Guyana, Georgetown, Guyana.