- Assistant Professor
- Office: 395K
- Phone: 401.874.4805
- Email: firstname.lastname@example.org
- Office Location: 7 Greenhouse Road, Kingston, RI 02881
Translational and basic research focusing on novel therapeutic approaches for the treatment of chronic liver and kidney diseases, including cholestasis and ischemia-reperfusion injury during organ transplantation. Research interests include: 1) molecular mechanisms of inflammation as it relates to chronic gastrointestinal diseases, 2) regulation of drug transporters in the setting of chronic liver diseases, and 3) nuclear receptors as therapeutic targets for liver and kidney injury.
Postdoctoral fellowship, Yale University, 2013
Ph.D., Pharmaceutical Sciences, University of Pittsburgh, 2010
Pharm.D., University of Rhode Island, 2004
Ghonem NS, Assis DN, Boyer JL (2015). Fibrates and Cholestasis: A Review. Hepatology, Aug;62(2):635-43.
Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL (2014). Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Hepatology, Mar;59(3):1030-42.
Ghonem NS and Boyer JL (2013). Fibrates as adjuvant therapy for chronic cholestatic liver disease: it’s time has come. Hepatology. May;57(5):1691-3.
Ghonem NS, Yoshida J, Murase N, Strom SC, Venkataramanan R (2012). Treprostinil improves hepatic CYP450 activity during rat liver transplantation. J Clin and Exp Hep. Dec;2(4):323-332.
Ozaki KS, Yoshida J, Ueki S, Pettigrew GL, Ghonem N, Sico RM, Lee LY, Shapiro R, Lakkis FG, Pacheco-Silva A, Murase N (2012). Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death. Transpl Int. Jan;1:107-17.
Ghonem N, Yoshida J, Stolz DB, Humar A, Starzl TE, Murase N, Venkataramanan R (2011). Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. Nov;11(11):2508-16.