Nisanne Ghonem, Pharm.D., Ph.D.

  • Assistant Professor
  • Office: 395K Lab: 320
  • Phone: 401.874.4805
  • Email: nghonem@uri.edu
  • Office Location: Avedisian Hall, 7 Greenhouse Road, Kingston, RI 02881
Research Website

 

Biography

Nisanne Ghonem, PharmD ’04, PhD, is an Assistant Professor of Biomedical and Pharmaceutical Sciences, specializing in translational pharmacology.

Research

Dr. Ghonem’s research focuses on the regulation of nuclear receptors for the treatment of liver and kidney diseases, including cholestatic liver diseases and ischemia-reperfusion injury during organ transplantation. Research includes cell culture, animal models, and clinical studies.

Education

Postdoctoral fellowship, Yale University, 2013
Ph.D., Pharmaceutical Sciences, University of Pittsburgh, 2010
Pharm.D., University of Rhode Island, 2004

Selected Publications

(ϯURI corresponding author)

Hou J, Tolbert E, Birkenbach M, Ghonem NSϯ (2021). Treprostinil alleviates hepatic mitochondrial injury during rat renal ischemia-reperfusion injury. Biomed Pharmacother Nov; 143:112172

Ding M, Tolbert E, Birkenbach M, Gohh R, Akhlaghi F, Ghonem NSϯ (2021). Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury. Biomed Pharmacother Sep; 141:111912

Gallucci GM, Trottier J, Hemme CL, Boyer JL, Assis DN, Barbier O, Ghonem NSϯ (2021). Adjunct fenofibrate up-regulates bile acid glucuronidation and improves treatment response for patients with cholestasis Hepatol Commun Aug 27. doi.org/10.1002/hep4.1787

Ding M, Birkenbach M, Tolbert E, Gohh R, Akhlaghi F, and Ghonem NSϯ (2021). Treprostinil, a prostacyclin analog, ameliorates renal ischemia-reperfusion injury: preclinical studies in a rat model of acute kidney injury. Nephrol Dialysis Transplant, Jan 25;36(2):257-266.

Ghonem NSϯ, Auclair AM, Hemme CL, Gallucci GM, de la Rosa Rodriguez R, Boyer JL, Assis DN, (2020). Fenofibrate improves liver function and reduces the toxicity of the bile acid pool in patients with primary biliary cholangitis and primary sclerosing cholangitis who are partial responders to Ursodiol. Clin Pharmacol Ther Dec;108(6):1213-1223

Ghonem NS, Assis DN, Boyer JL (2015). Fibrates and Cholestasis. Hepatology, Aug;(2):635-43

Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL (2014). Peroxisome proliferator-activated receptor-alpha (PPARα) activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Hepatology, Mar;59(3):1030-42.

Ghonem NS and Boyer JL (2013). Fibrates as adjuvant therapy for chronic cholestatic liver disease: it’s time has come. Hepatology. May;57(5):1691-3.

Ghonem NS, Yoshida J, Murase N, Strom SC, Venkataramanan R (2012). Treprostinil improves hepatic    CYP450 activity during rat liver transplantation. J Clin and Exp Hep. Dec;2(4):323-332.

Ozaki KS, Yoshida J, Ueki S, Pettigrew GL, Ghonem N, Sico RM, Lee LY, Shapiro R, Lakkis FG, Pacheco-Silva A, Murase N (2012). Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death. Transpl Int. Jan;1:107-17.

Ghonem N, Yoshida J, Stolz DB, Humar A, Starzl TE, Murase N, Venkataramanan R (2011). Treprostinil, a prostacyclin analog, ameliorates I/R injury in rat OLT. Am J Transplant. Nov (11):2508-16.