Todd Brothers, Pharm.D., BCCCP, BCPS

Biography

Dr. Todd Brothers, PharmD, BCCCP, BCPS, is a Clinical Associate Professor of Pharmacy Practice and Clinical Research at the University of Rhode Island College of Pharmacy. He is a licensed pharmacist and board-certified in both Critical Care (BCCCP) and Pharmacotherapy (BCPS), with additional certification in pharmacogenomics. His professional background spans over two decades of clinical practice, education, and research in acute and critical care settings.

Clinically, Dr. Brothers maintains an active practice in adult critical care at Roger Williams Medical Center, where he contributes to antimicrobial stewardship, medication safety, and interdisciplinary ICU care. His clinical work emphasizes optimizing pharmacotherapy in complex, high-acuity patients and improving patient-centered outcomes.

In his academic role, Dr. Brothers is a dedicated educator and mentor. He serves as Course Coordinator for Clinical & Therapeutic Sciences (PHP 527), Co-Coordinator for Precision Medicine and Applied Pharmacogenomics (BPS/PHP 547), and a preceptor for advanced pharmacy practice experiences in critical care. He teaches across PharmD, graduate, and interprofessional programs and is widely recognized for his engaging, clinically grounded teaching style. In recognition of his contributions to education, he was named the 2025 University of Rhode Island College of Pharmacy Faculty of the Year.

Dr. Brothers is actively engaged in professional and institutional service. He serves as Co-Chair of the Rhode Island Medicaid Pharmacy and Therapeutics Committee and as an Executive Council Member of the Rhode Island Pharmacists Association, contributing to statewide policy, formulary decision-making, and advancement of pharmacy practice.

His research lies at the intersection of critical care pharmacotherapy, chronic kidney disease (CKD), and artificial intelligence–driven precision medicine. He focuses on leveraging large-scale electronic health record (EHR) data, machine learning, and synthetic data to identify clinically meaningful patient subgroups, predict disease progression, and optimize medication-related outcomes. He serves as Co-Principal Investigator on the ACCP Foundation–funded OPTOCS-AI project, which aims to optimize pharmacy-led transitions of care using artificial intelligence, and contributes to an NIH/NHLBI R21 proposal developing an AI-driven dashboard for heart failure transitions of care.

Research

Through this work, Dr. Brothers aims to advance AI-enabled clinical decision support, improve transitions of care, reduce readmissions, and move healthcare toward more precise, data-driven, and individualized pharmacotherapy.

Education

Doctor of Pharmacy, Massachusetts College of Pharmacy and Allied Health Sciences- Boston, 2002

Certifications

ACCP Certification: Pharmacogenomics, 2019   
Board Certification: Critical Care (7151992), 2018  
Board Certification: Pharmacotherapy (3100109), 2010

Selected Publications

Synthetic Data–Augmented Machine Learning for 30-Day Readmission Prediction (BMJ Open, 2026). doi:10.1136/bmjopen-2025-108273

Bidirectional Association Between Depression and Chronic Kidney Disease (Frontiers in Nephrology, 2026). doi:10.3389/fneph.2025.1743594

Machine Learning Framework for Identifying CKD Phenotypes (Healthcare Analytics, 2025). doi:10.1016/j.health.2025.100425

Synthetic Data–Driven Early Prediction of Acute Kidney Injury (Pharmacotherapy, 2025). doi:10.1002/phar.70064

Kidney Disease Progression Using Patient Profiling Algorithms (PLOS ONE, 2025). doi:10.1371/journal.pone.0310749

 

Reduction in Chronic Post-Surgical Opioid Utilization (Lancet Regional Health – Americas, 2025). doi:10.1016/j.lana.2024.100977

Wen X, Otoo MN, Tang J, Brothers T, Ward KE, Asal N, Meador KJ. Angiotensin Receptor Blockers for Hypertension and Risk of Epilepsy. JAMA Neurology. 2024 Jun 17:e241714. 

Wen X, Brothers T, Ward K, Kogut S. Reducing the Risks of Prenatal Opioid Exposure in Children. BMJ 2024;384:q803.  

Brothers T, Furtado M, Al-Mamun MA. Thiamine Utilization and the Lack of Prescribing Standardization: A Critical Examination. Alcohol. 2024 Jun;117:11-19. 

Mbous Y, Brothers T, Al-Mamun M. Medication Regimen Complexity Index Score at Admission as a Predictor of Inpatient Outcomes: A Machine Learning Approach. International Journal of Environmental Research and Public Health. 2023; 20(4):3760.            

Brothers T, Strock J, LeMasters TJ, Pawasauskas J, Reed RC and Al-Mamun MA.  Survival and Recovery Modeling of Acute Kidney Injury in Critically Ill Adults. SAGE Open Medicine 2022;(10):1-13.      

Oluwadolapo L, Gold J, Murthy A, Brothers T, et al. Rate and Risk Factors Associated with Prolonged Opioid Use After Surgery. A Systematic Review and Meta-Analysis. JAMA Network Open 2020;3(6):e207367. 

Honors and Awards

Top 5% ISPOR Finalist Research Award Recipient, 2024
APPE Preceptor of the Year- University of Rhode Island, 2013
Rhode Island Society of Health-Systems Pharmacists- New Clinical Pharmacy Practitioner of the Year, 2007
Excellence in Clinical Pharmacy Practice- Massachusetts College of Pharmacy and Allied Health Sciences- Boston, 2002