College of Pharmacy

Avedisian Hall, 7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.eduOffice: 401.874.2761 Fax: 401.874.2181

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Xinyuan Chen, Ph.D.

  • Assistant Professor
  • Office: 395L Lab: 480
  • Phone: 401.874.5033
  • Email:
  • Office Location: 7 Greenhouse Road, Kingston, RI 02881


My research focuses on developing novel laser-based approaches to facilitate transdermal drug/vaccine delivery (1) and improve vaccine/adjuvant safety (2), and fabricating the right formulation and device for such purposes (3).


Instructor, Massachusetts General Hospital, MA 2012-2015

Post-doc, Massachusetts General Hospital, MA 2008-2011

Post-doc, Burke Medical Research Institute, NY, 2007

Ph.D., Nanjing University, 2006

B.S., Nanjing University, 2001


Zhou C, Chen X, Zhang Q, Wang J, Wu MX. Laser mimicking mosquito bites for skin delivery of malaria sporozoite vaccines. J Control Release. 2015; 204C:30-37.

Chen X*, Kositratna G, Zhou C, Manstein D, Wu MX. “Micro-fractional epidermal powder delivery for improved skin vaccination”. J Control Release, 2014, 192:310-6. PMCID: PMC4171958. *, co-corresponding author.

Wang J, Shah D, Chen X, Anderson RR, Wu MX. “Micro-sterile inflammation array as safe adjuvant for influenza vaccines”, Nature Communications. 2014, 5:4447.

Chen X, Wang J, Shah D, Wu MX. “An update on the use of laser technology in vaccine immunization”. Expert Rev Vaccines. 2013, 12 (11), 1313-1323.

Chen X, Shah D, Kositratna G, Manstein D, Anderson RR, Wu MX, Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology. J Control Release. 2012; 159(1):43-51. PMCID: PMC3322279

Chen X, Pravetoni M, Bhayana B, Pentel PR, and Wu MX, Improve nicotine vaccine immunogenicity by combined intradermal delivery and cutaneous adjuvants. Vaccine. 2012; 31(1):159-64. PMCID: PMC3557791

Chen X, Zeng QY, Wu MX. Improved Efficacy of DC-based immunotherapy by cutaneous laser illumination. Clin Cancer Res. 2012; 18(8):2240-9.  PMCID: PMC3328606

Chen X, Wu MX. How effective could laser-based approaches be in assisting dendritic cell immunotherapy? Immunotherapy. 2012; 4(10):983-5.

Zhi L, Ustyugova IV, Chen X, Zhang Q, Wu MX. Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling. J Immunol. 2012;189(4):1639-47. PMCID: PMC3440304

Chen X, Wu MX. Laser vaccine adjuvants for transcutaneous immunization. Expert Review of Vaccines. 2011, 10(10):1397-403.   PMCID: PMC3250349

Chen X, Kim P, Farinelli B, Doukas A, Yun SH, Gelfand JA, Anderson RR, Wu MX. A Novel Laser Vaccine Adjuvant increases the Motility of Antigen Presenting Cells. PLOS one. 2010, 5(10):e13776. PMCID: PMC2966445

Shahid M, Shen L, Seldin DC, Lu B, Ustyugova IV, Chen X, Zapol WM, Wu MX. Impaired 3′, 5’-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. Hypertension. 2010; 56(4):705-12. PMCID: PMC3157252

Kim E, Tolhurst AT, Qin LY, Chen XY, Febbraio M, Cho S. CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury. J Neurosci. 2008;28(18):4661-70. PMCID: PMC2830708

Fu ZH, Wang JH, Sun JH, Chen XY, Xu JG. Fu’s subcutaneous needling-Possible clinical evidence of the subcutaneous connective tissue in acupuncture. J Altern Complement Med. 2007;13(1):47-51

Chen XY, Zhang W, Zhang W, Wu S, Bi F, Su YJ, Tan XY, Liu JN, Zhang J. Vaccination with viable HUVECs prevents metastatic tumors by attack on tumor vasculature with both cellular and humoral immunity. Clin Cancer Res. 2006; 12(19):5834-5840.

Fu ZH, Chen XY, Lu LJ, Lin J, Xu JG. Immediate effect of Fu’s Subcutaneous Needling for Low Back Pain. Chin Med J. 2006, 119(11): 953-956.

Ding BS, Zhou YJ, Chen XY, Zhang J, Zhang PX, Sun ZY, Tan XY, Liu JN. Lung Endothelium Targeting for Pulmonary Embolism Thrombolysis. Circulation. 2003; 108:2892-2898.


Book Chapter

Chen X, Wu MX. Laser for skin vaccine delivery and adjuvantation. Molecular Vaccines from Prophylaxis to Therapy, Book Chapter, 2014/1/1, 519-525.

Chen X*, Wang J, Wu JH, Wu MX. Skin Vaccination against Nicotine Addiction. (*, co-corresponding author)

Feng J, Liu SW, Wu MX, Chen X. Micro-Fractional Epidermal Powder Delivery for Skin Vaccination. (Corresponding author)

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