Tick Control Products for Pets

feeding dog a chew medicine

Preventing tick bites is the first line of defense for keeping pets safe.

There are many different products on the market today that protect your pets from tick-transmitted diseases. The most popular tick bite prevention products are topical sprays and spot-ons. Correctly and timely applied to your pets skin, these products can greatly reduce the chances of tick bites. Products that kill on contact will keep your pet from bringing in ticks that may pose a risk to you or your family members.

ProductWhole Body ProtectionKills TicksKills Ticks Before BitingKills FleasWater ResistantSafe for CatsSafe for Dog/Cat HouseholdsOral Chew/Systemic Action
K9 AdvantixII 
Permethrin* /Imidacloprid*
YesYesYesYesYesNoYes**No
Vectra 3D
Dinotefuran, Pyriproxyfen, Permethrin
YesYesYesYesYesNoYesNo
Simparica Trio
Sarolaner*, Moxidectin* , pyrantel*
YesYesNoYesYesNoYesYes
NEXGARD Plus for dogs 
Afoxolaner*, Moxidectin*,
pyrantel*
YesYesNoYesYesNoYesYes
Credelio Quattro
lotilaner*, moxidectin*, praziquantil*, pyrantel*
Yes YesNoYesYesNoYesYes
Frontline Gold 
fipronil*, (S)-methoprene*, pyriproxyfen*
YesYesNoYesYesYesYesNo
NEXGARD Combo (cats) esafoxolaner*, eprinomectin*,
praziquantel*
Yes. YesNoYesYesYesYesNo (topical)
Frontline Shield (New)
Fipronil* / permethrin*/ pyriproxyfen
YesYesYesYesYesNoYesNo
Revolution Plus 
Selamectin*/
Sarolaner*
YesYesNoYesYesYesYesNo
(topical)
Preventic Collar 
Amatraz*
NoYesNoNoYesNoNoNo
Seresto Collar 
Flumethrin*/ Imidacloprid*
YesYesYesYesYesYesYesNo
 *Active Ingredients
**Contact Elanco Veterinary Services 800-255-6826 for use in mixed households with cats.

Different products have different active ingredients. Before choosing a product, it is important to understand the facts about each one. Ask your veterinarian or click on the links to learn more about each of the recommended products. Products that kill ticks fast (within 24 hours) will better protect your pet from diseases. To protect your family from ticks that may be crawling on your pet, we recommend products that either kill ticks on contact or cause rapid tick detachment.

Product Information

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