college of pharmacy

7 Greenhouse Road Kingston, RI 02881

pharmcol@etal.uri.edu – Office: 401.874.2761 Fax: 401.874.2181

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The University of Rhode Island Doctor of Pharmacy program is accredited by the Accreditation Council for Pharmacy Education.

Navindra Seeram, Ph.D.

navindra_seeram_web
  • Associate Professor
  • Office: 495B Lab: 440
  • Phone: 401.874.9367
  • Email: nseeram@uri.edu
  • Mailing Address: 7 Greenhouse Road, Kingston, RI 02881

Biography

researchwebsiteNavindra P. Seeram, Ph.D., is an Associate Professor in the Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, USA. Prior to this, he was the Assistant Director of the UCLA Center for Human Nutrition in the Department of Medicine, University of California, Los Angeles, and an Assistant Professor in the UCLA School of Medicine. His research group, the Bioactive Botanical Research Laboratory, investigates plant foods and natural products for therapeutic and preventive effects against chronic human diseases.

Dr. Seeram has co-authored over 100 peer-reviewed research articles, 14 book chapters, and 6 international patents. He has co-edited 3 books and is the founding editor of the Clinical Pharmacognosy book series published by CRC Press/Taylor and Francis. He serves on the editorial boards of the Journal of Berry Research and the International Journal of Applied Research in Natural Products.

He was the recipient of the 2009 Young Scientist Award from the Agricultural and Food Chemistry Division of the American Chemical Society and is regularly quoted in the media and popular press about medicinal foods. Dr. Seeram did his doctoral and postdoctoral studies at the University of the West Indies in Jamaica and at Michigan State University, USA, respectively.

Professional Experience

July 2013-present:          Associate Professor with tenure, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Dec 2007-June 2013:     Assistant Professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Aug 2003-Dec 2007:      Assistant Adjunct Professor, Division of Clinical Nutrition, Department of Medicine, University of California, Los Angeles, CA, USA.

Nov 2002- Dec 2007:     Assistant Director, UCLA Center for Human Nutrition, Department of Medicine, University of California, Los Angeles, CA, USA.

July 1999-Sep 1999:       Senior Scientific Officer, Scientific Research Council, Kingston, Jamaica, West Indies.

June 1998-June 1999:     Senior Forensic Officer, Police Forensic Laboratory, Ministry of National Security, Kingston, Jamaica, West Indies.

June 1992-June 1998:     Tutorial/Teaching Assistant, University of the West Indies, Kingston, Jamaica, West Indies.

June 1990-June 1992:     Chemistry Teacher, Manchester High School, Mandeville, Jamaica, West Indies.

Research

Bioassay-guided discovery of natural products from medicinal plants including medicinal foods targeting cancer, diabetes, and inflammation; Investigation of bioavailability, metabolism, tissue disposition, and mechanisms of action of bioactive food components.

Education

Post-Doctoral Fellow, Michigan State University, 1999-2002

Ph.D. Natural Products Chemistry, University of the West Indies, Kingston, Jamaica, 1998

B.Sc., Chemistry (major) & Biology (minor) with Distinction, University of Guyana, Georgetown, Guyana, South America, 1990.

Publications

Original Articles in Peer-Reviewed Journals

Guo, L.; Panderi,  I.; Yan, D.D.; Szulak, K.; Li, Y.; Chen, Y.T.; Ma, H.; Niesen, D.B.; Seeram, N.; Ahmed, A.; Yan, B.; Pantazatos, D.;  Lu, W. A Comparative study of hollow copper sulfide nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano. 2013, PubMed PMID: 24053214.

Nahar, P.; Driscoll, M.; Li, L.; Slitt, A.L.; Seeram, N.P. Phenolic mediated anti-inflammatory effects of a maple syrup extract against RAW264.7 macrophages, Journal of Functional Foods, 2013, in press.

Yuan, T.; Wan, C.; Ma, H.; Seeram, N.P. Novel phenolics from the flowers of Punica granatum and their α-glucosidase inhibitory activities, Planta Medica, 2013, 79, 1-6.

Pericherla, K.; Shirazi, A.N.; Rao, V.K.; Tiwari, R.; DaSilva, N.; Mccaffrey, K.T.; Beni, Y.A.; González-Sarrías, A.; Seeram, N.P.; Parang, K.; Kumar, A. Synthesis and antiproliferative activities of Quebecol and its analogs.  Bioorganic Medicinal Chemistry Letters, 2013, in press.

Yuan, T.; Li, L.; Zhang, Y.; Seeram, N.P. Pasteurized and sterilized maple sap as functional beverages: Chemical composition and antioxidant activities. Journal of Functional Foods, 2013, in press.

Jean-Gilles, D.; Li, L.; Vaidyanathan, V.G.; King, R.; Cho, B.; Worthen, D. R.; Chichester, C.O.; Seeram, N.P. Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo. Chemico-Biological Interactions, 2013, 205, 90-99.

Beckford, F.; Brock, A.; González-Sarrías, A.; Seeram, N.P. Novel microwave synthesis of half-sandwich [(h6-C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity. Applied Organometallic Chemistry, 2013, 27, 425-434.

Bolser, J.A.; Alan, R.R.; Smith, A.D.; Li, L.; Seeram, N.P.; McWilliams, S.R. Birds select fruits with more anthocyanins and phenolic compounds during autumn migration, Wilson Journal of Ornithology, 2013, 125, 97-108.

Woode, D.R.; Aiyer, H.S.; Sie, N.; Zwart, A.L.; Li, L.; Seeram, N.P.; Clarke, R. Effect of berry extracts on fulvestrant (ICI 182,780) sensitive and resistant cell lines, International Journal of Breast Cancer, 2012, doi:10.1155/2012/147828; Epub article; 11 pages

González-Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S- and G2/M-cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels. Food Chemistry, 2013, 136, 636-642.

Tao, Y.; Ding, Y.; Wan, C.; Li, L.; Xu, J.; Liu, K.; Slitt, A.; Ferreira, D.; Khan, I.A.; Seeram, N.P. Antidiabetic ellagitannins from pomegranate flowers: Inhibition of a-glucosidase and lipogenic gene expression. Organic Letters, 2012, 14, 5358-61.

Seeram, N.P.; Xu, J.; Li, L.; Slitt, A. Mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes. Medicine and Health Rhode Island, 2012, 95, 283-284.

Omar, R.; Li, L.; Tao, Y.; Seeram, N.P. a-Glucosidase inhibitory hydrolyzable tannins from Eugenia jambolana seeds. Journal of Natural Products, 2012, 75, 1505-1509.

Wan, C.; Yuan, T.; Cirello, A.; Seeram, N.P. Antioxidant and a-glucosidase inhibitory phenolics from highbush blueberry flowers. Food Chemistry, 2012, 135, 1929-1937.

Apostolidis, E.; Li, L.; Kang, B.; Lee, C.M.; Seeram, N.P. Seasonal influence on phenolic-mediated antihyperglycemic properties of Canadian sugar and red maple leaves using in vitro assay models. Food Science and Biotechnology, 2012, 3, 753-760.

González-Sarrías, A.; Tao, Y.; Seeram, N.P. Cytotoxicity and structure activity relationship studies of  maplexins A-I, gallotannins from red maple (Acer rubrum). Food and Chemical Toxicology, 2012, 50, 1369-1376.

Wan, C.; Yuan, T.; Xie, M.; Seeram, N.P. Acer rubrum phenolics include A-type procyanidins and a chalcone. Biochemical Systematics and Ecology, 2012, 44, 1-3.

Ma, H.; Tao, Y.; González-Sarrías, A.; Li, L.; Edmonds, M.E.; Seeram, N.P. New galloyl derivative from winged sumac (Rhus copallinum) fruit. Natural Products Communications, 2012, 7, 45-46.

Laplante, K.L.; Sarkisian, S. A.; Woodmansee, S.; Rowley, D.C.; Seeram, N.P. Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. Phytotherapy Research, 2012, 26, 1371-1374.

Jean-Gilles, D.; Li, L.; Ma, H.; Yuan, T.; Chichester, C.O.; Seeram, N.P. Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. Journal of Agricultural and Food Chemistry, 2012, 60, 5755-5762.

Lewis, N.A.; Liu, F.; Seymour, L.; Magnusen, T.; Erves, T.; Arca, F.A.; Beckford,F.A.; Venkatraman, R.; González-Sarrías, A.; Fronczek, F.R.; VanDerveer, D.G.; Seeram, N.P.; Liu, A.; Jarrett, W.L.; Holder, A.A. Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a schiff base and thiosemicarbazones as mixed-ligands. European Journal of Inorganic Chemistry, 2012, 4, 664-677.

Yuan, T.; Wan, C.; Liu, K.; Seeram, N.P. New maplexins F-I and phenolic glycosides from red maple (Acer rubrum) bark. Tetrahedron, 2012, 68, 959-964.

Wan, C.; Yuan, T.; Li, L.; Kandhi, V.; Cech, N.B.; Xie, M.; Seeram, N.P. Maplexins, new a-glucosidase inhibitors from red maple (Acer rubrum) stems. Bioorganic Medicinal Chemistry Letters, 2012, 22, 597-600.

Beckford, F.; Thessing, J.; Stott, A.; Holder, A. A.; Poluektov, O.G.; Li, L.; Seeram, N.P. Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides. Inorganic Chemistry Communications, 2012, 15, 225-229.

González-Sarrías, A.; Li, L.; Seeram, N.P. Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells. Journal of Functional Foods, 2012, 4, 185-196.

Donepudi, A.C.; Goedken, M.J.; Aleksunes, L.M.; Seeram, N.P.; Slitt, A. The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit) decreases liver inflammation, injury and fibrosis during cholestasis. Liver International, 2012, 32, 560-573.

González-Sarrías, A.; Li, L.; Seeram, N.P. Effects of maple (Acer) plant part extracts on proliferation, apoptosis, and cell cycle arrest of human tumorigenic and non-tumorigenic colon cells. Phytotherapy Research, 2012, 26, 995-1002.

LeBlanc, M-A.; Gonzales-Sarrias, A.; Beckford, F.; Mbarushimana, P.C.;  Seeram, N.P. Coordination chemistry of polyaromatic thiosemicarbazones. 2: Synthesis and biological activity of zinc, cobalt and copper complexes of 1-(naphthalene-2-yl)ethanone thiosemicarbazone. International Journal of Inorganic Chemistry, 2011, accepted. doi:10.1155/2011/624756.

Apostolidis, E.; Karayannakidis, P.D.; Kwon, Y-I.; Lee, C.M.; Seeram, N.P.  Seasonal variation of phenolic antioxidant-mediated a-glucosidase inhibition of Ascophyllum nodosum. Plant Foods for Human Nutrition, 2011, 66, 313-319.

Yuan, T.; Wan, C.; González-Sarrías, A.; Kandhi, V.; Cech, N.B.; Seeram, N.P. Phenolic glycosides from sugar maple (Acer saccharum) bark. Journal of Natural Products, 2011, 74, 2472-2476.

González-Sarrías, A.; Gromek, S.; Niesen, D.; Seeram, N.P.; Henry, G.E. Resveratrol oligomers isolated  from Carex species inhibit proliferation of human colon tumorigenic cells inhibited by cell cycle arrest. Journal of Agricultural and Food Chemistry, 2011, 59, 8632-8638.

Ponnala, S.; Chaudhary, S.; González-Sarrías, A.; Seeram, N.P.; Harding, W.W. Cytotoxicity of aporphines in human colon cancer cell lines, HCT-116 and Caco-2: an SAR study. Bioorganic and Medicinal Chemistry Letters, 2011, 21, 4462-4464.

Li, L.; Seeram, N.P. Further investigation into maple syrup yields three new lignans, a new phenylpropanoid, and twenty-six other phytochemicals. Journal of Agricultural and Food Chemistry, 2011, 59, 7708-7716.

Henning, S.M.; Zhang, Y.; Seeram, N.P.; Bowerman, S.; Heber, D. Antioxidant capacity of herbs in dried, fresh, and blended paste forms. International Journal of Food Science and Nutrition, 2011, 62, 219-225.

Beckford, F.A.; Thessing, J.; Shaloski, M.; Mbarushimana, P.C.;  Brock, A.; Didion, J.; Woods, J.; González-Sarrías, A.; Seeram, N.P. Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents. Journal of Molecular Structure, 2011, 992, 39-47.

Beckford, F. A.; Thessing, J.; Woods, J.; Didion, J.; Gerasimchuk, N.; González-Sarrías, A.; Seeram, N.P. Synthesis and structure of [(η6-p-cymene)Ru(2-anthracen-9 ylmethylene-N-ethylhydrazinecarbothioamide)Cl]Cl: Biological evaluation, topoisomerase-II inhibition and reaction with DNA and human serum albumin. Metallomics, 2011, 3, 491-502.

Beckford, F.A.; Shaloski,  M.; Thessing, J.; Woods, J.; Dourth, D.; Didion, J.; Gerasimchuk, N.;  González-Sarrías, A.; Seeram, N.P. Half-sandwich ruthenium-arene complexes with thiosemicarbazones: Synthesis and biological evaluation of [(n6-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl. Journal of Inorganic Biochemistry, 2011, 105, 1019-1029.

Apostolidis, E.; Li, L.; Lee, C.M.; Seeram, N.P. In vitro evaluation of phenolic-enriched extracts of maple syrup for inhibition of carbohydrate hydrolyzing enzymes relevant to type 2 diabetes. Journal of Functional Foods, 2011, 3, 100-106.

Li, L.; Seeram, N.P. Quebecol, a novel phenolic compound isolated from Canadian maple syrup. Journal of Functional Foods, 2011, 3, 125-128.

Hong, M-Y.; Henning, S.M.; Moro, A.; Seeram, N.P.; Zhang, Y.; Heber, D. Chinese Red Yeast Rice inhibition of prostate tumor growth in SCID mice. Cancer Prevention Research, 2011, 4, 608-615.

Manning, K.; Petrunak, E.; Lebo, M.; González-Sarrías, A.; Seeram, N.P.; Henry, G.E. Acylphloroglucinols and xanthones from Hypericum ellipticumPhytochemistry, 2011, 72, 662-667.

Ma, H.; Li, L.; Seeram, N.P. Phenolics from Cornus amomum Mill. fruit. Biochemical Systematics and Ecology, 2010, 38, 1083-1084.

Li, L.; Woolridge, D.; Saing, S.R.; Jennings, J.; Henry, G.E.; Seeram, N.P. Flavonoids and a stilbene from Triadenum fraseri (Spach) Gleason.  Biochemical Systematics and Ecology, 2010, 38, 1074-1076.

Li, L.; Seeram, N.P. Maple syrup phytochemicals include lignans, coumarins, a stilbene and other previously unreported antioxidant phenolic compounds. Journal of Agricultural and Food Chemistry, 2010, 58, 11673-11679.

Zunino, S.; Zhang, Y.; Seeram, N.P.; Storms, D.  Berry fruit extracts inhibit growth and induce apoptosis of high risk acute lymphoblastic leukemia cells in vitro. Journal of Functional Foods, 2010, 2, 185-195.

Adams, L.S.; Phung, S.; Yee, N.; Seeram, N.P.; Li, L.; Chen, S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol-3-kinase pathway. Cancer Research, 2010, 70, 3594-605.

Sharma, M.; Li, L.; Celver, J.; Killian, C.; Kovoor, A.; Seeram, N.P. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. Journal of Agricultural and Food Chemistry, 2010, 58, 3965-3969.

Koyama, S.; Cobb, L.J.; Mehta, H.H.; Seeram, N.P.; Heber, D.; Pantuck, A.J.; Cohen P. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Hormone IGF Research, 2010, 20, 55-62.

Adams, L.S.; Zhang, Y.; Seeram, N.P.; Heber, D.; Chen. S. Pomegranate ellagitannin derived compounds exhibit anti-proliferative and anti-aromatase activities in breast cancer cells in vitro. Cancer Prevention Research, 2010, 3,108-113.

Henning, S.M.; Seeram, N.P.; Zhang, Y.; Li, L.; Gao, K.; Lee, R.; Wang, D.C.; Zerlin, A.; Karp, H.; Thames, G.; Kotlerman, J.; Li, Z.; Heber, D. Strawberry consumption is associated with increased antioxidant capacity in serum.  Journal of Medicinal Foods, 2010, 13, 116-122.

Beckford, F.; Leblanc, G.; Thessing, J.; Shaloski, M.; Frost, B.J.; Li, L.; Seeram, N.P. Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(6-p-cymene)Ru(NS)Cl]+ (NS = 9-anthraldehyde thiosemicarbazones).  Inorganic Chemistry Communications, 2009, 12, 1094-1098

Beckford, F.; Shaloski, M.; Leblanc, G.; Thessing, J.; Lewis -Alleyne, L.C.; Holder,A. A.; Li, L.; Seeram, N.P. Microwave synthesis of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity. Dalton Transactions, 2009, 48, 10757-10764.

Henry, G.E.; Campbell, M.; Zelinsky, A.A.; Liu, Y.; Bowen-Forbes, C.S.; Li, L.; Nair, M.G.; Rowley, D.C.; Seeram, N.P. Bioactive acylphloroglucinols from Hypericum densiflorum. Phytotherapy Research, 2009, 23, 1759-1762.

Li, L.; Henry G.E.; Seeram, N.P. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds.  Journal of Agricultural and Food Chemistry, 2009, 57, 7282-7287.

Zunino, S.J.; Storms, D.H.; Zhang, Y.; Seeram, N.P. Growth arrest and induction of apoptosis in high-risk leukemia cells by strawberry components. Journal of Functional Foods, 2009, 1, 153-160.

Zhang, Y.; Krueger, D.; Durst, R.; Lee, R.; Wang, D.; Seeram, N.P.; Heber, D. International Multidimensional Authenticity Specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration. Journal of Agricultural and Food Chemistry, 2009, 57, 2550-2557.

Li, L.; Zhang, Y.; Seeram, N.P. Structure of anthocyanins from Eugenia jambolana fruit.  Natural Products Communications, 2009, 4, 217-219.

Li, L.; Adams, L.S.; Chen, S.; Killian, C.; Ahmed, A.; Seeram, N.P. Eugenia jambolana  Lam. berry extract inhibits proliferation and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. Journal of Agricultural and Food Chemistry, 2009, 57,826-831.

Sathe, S.K.; Seeram, N.P.; Kshirsagar H.H.; Heber, D.; Lapsley, K.A. Fatty acid composition of California grown almonds. Journal of Food Sciences, 2008, 73, C607-14.

Hong, M.Y.; Seeram, N.P.; Zhang, Y.; Heber, D. Chinese Red Yeast Rice vs. Lovastatin effects on prostate cancer cells with and without androgen receptor overexpression. Journal of Medicinal Foods, 2008, 11, 657-666.

Hong, M.Y.; Seeram, N.P.; Heber, D. Pomegranate polyphenols downregulate expression of androgen synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. Journal of Nutritional Biochemistry, 2008, 19, 848-55.

Hong, M.Y.; Seeram, N.P.; Zhang, Y.; Heber, D. Anticancer effects of Chinese Red Yeast Rice versus monacolin alone on colon cancer cells. Journal of Nutritional Biochemistry, 2008, 19, 448-458.

Rettig, M.B.; Heber, D.; An, J.; Seeram, N.P.; Liu, H.; Rao, J.Y.; Liu, H.; Klatte, T.; Belldegrun, A.; Moro, A.; Henning, S.M.; Mo, D.; Aronson, W.J.; Pantuck, A.J. Pomegranate extract inhibits androgen-independent prostate cancer growth through a  nuclear factor-Kb-dependent mechanism. Molecular Cancer Therapeutics, 2008, 7, 2662-2671.

Seeram, N.P.; Zhang, Y.; McKeever, R.; Henning, S.M.; Lee, R.; Sartippour, M.; Suchard, M.A.; Li, Z.; Chen, S.; Thames, G.; Zerlin, A.; Nguyen, M.; Wong, D. Heber, D. Ellagitannin metabolites are present in human plasma and urine in similar levels after consumption of pomegranate fruit juice and its liquid and solid extracts. Journal of Medicinal Foods, 2008, 11, 390-394.

Seeram, N.P.; Aviram M.; Zhang, Y.; Henning, S.M.; Dreher, M.; Heber, D. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. Journal of Agricultural and Food Chemistry, 2008, 56, 1415-1422. (Most accessed article for year 2008 in the Journal of Agricultural and Food Chemistry).

Zhang, Y.; Seeram, N.P.; Lee, R.; Feng, L.; Heber, D. Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative activities. Journal of Agricultural and Food Chemistry, 2008, 56, 670-675.  (Most accessed article for Jan-Mar 2008 in the Journal of Agricultural and Food Chemistry).

Sartippour, M.; Seeram, N.P.; Rao, J.Y.; Moro, A.; Harris, D.M.; Firozi, A.; Rettig, M.; Aronson, W.J.; Pantuck, A.J.; Heber, D. Ellagitannin-rich pomegranate extract inhibit angiogenesis in prostate cancer in vitro and in vivo. International Journal of Oncology, 2008, 32, 475-80.

Venkatachalam, M.; Kshirsagar H.H.; Seeram, N.P.; Heber, D.; Thompson, T.T.; Roux, K.H.; Sathe, S.K. Biochemical composition and immunological comparison of select pecan [Carya illinoinensis (Wangenh.) K. Koch] cultivars. Journal of Agricultural and Food Chemistry, 2007, 55, 9899-07.

Heber, D.; Seeram, N.P; Wyatt, H.; Henning, S.M.; Zhang, Y.; Ogden, L.G.; Dreher, M.; Hill, J.O. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol extract dietary supplement in overweight individuals with increased waist size. Journal of Agricultural and Food Chemistry, 2007, 55,10050-10054.

Seeram, N.P.; Aronson, W.J.; Zhang, Y.; Henning, S.M.; Moro, A.; Lee, R.; Sartippour, M.; Harris, D.M.; Rettig, M.B.; Suchard, M.A.; Pantuck, A.J.; Belldegrun, A.; Heber, D. Pomegranate ellagitannin derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. Journal of Agricultural and Food Chemistry, 2007, 55, 7777-7785. (Most accessed article for Oct-Dec 2007 in the Journal of Agricultural and Food Chemistry)

Bobe, G.; Wang, B.; Seeram, N.P.; Nair, M.G.; Bourquin. L.D.   Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APCMin mice fed suboptimal levels of sulindac.  Journal of Agricultural and Food Chemistry 2006, 54, 9322-9328.

Seeram, N.P.; Adams, L.S; Zhang, Y; Sand, D.; Heber, D. Blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. Journal of Agricultural and Food Chemistry, 2006, 54, 9329-39. (Most accessed article for Oct-Dec 2006 in the Journal of Agricultural and Food Chemistry)

Li, Z.; Seeram, N.P.; Carpenter, C.; Thames, G.; Minutti, C.; Bowerman, S. Effect of cranberry on INR in subjects on warfarin for atrial fibrillation. Journal of American Dietetic Association, 2006, 106, 2057-2061.

Henry, G.E.; Raithore, S.; Zhang, Y.; Jayaprakasam B.; Nair, M.G.; Heber, D.; Seeram, N.P. Acylphloroglucinol derivatives from Hypericum prolificum. Journal of Natural Products, 2006, 69, 1645-1648.

Henry, G.E.; Adams, L.S.; Rosales, J.C.; Jacobs, H.; Heber, D.; Seeram, N.P. Kaurene  diterpenes from Laetia thamnia inhibit the growth of human cancer cell lines in vitro.   Cancer Letters, 2006, 244, 190-194.

Seeram, N.P.; Henning, S.M.; Zhang, Y.; Suchard, M.; Li, Z.; Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. Journal of Nutrition, 2006,136, 2481-2485.

Seeram, N.P.; Zhang, Y.; Henning, S.M.; Lee, R.; Niu, Y.; Lin, G.; Heber D. Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative properties. Journal of Agricultural and Food Chemistry, 2006, 54, 7036-7040.

Kobayashi, N.; Barnard, R.J.; Henning, S.H.; Elashoff, D.; Reddy, S.T.; Cohen, P.; Leung, P.; Hong-Gonzalez, J.; Freedland, S.J.; Said, J.; Gui, D.; Seeram, N.P.; Popoviciu, L.M.; Bagga, D.; Heber, D.; Glaspy, J.A.; Aronson, W.J. Effect of altering dietary omega-6:omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2 and prostaglandin E-2. Clinical Cancer Research, 2006, 12, 4662-4670.

Sarafian, T.; Habib, N.; Oldham, M.; Seeram, N.P.; Lee, R.; Tashkin, D.P.; Roth, M.D. Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006, 290, L1202-209.

Muller, C.I.; Kumagai T.; Kelly, J.O.; Seeram, N.P.; Heber, D.; Koeffler, P.H. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leukemia Research, 2006, 30, 841-848.

Pantuck, A.J.; Leppert, J.T.; Zomorodian, N.; Aronson, W.; Hong, J.; Barnard, R.J.; Seeram, N.P.; Liker, H.; Wang, H-E.; Elashoff, R.; Heber, D.; Aviram, M.; Ignarro, L.;  Belldegrun, A. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clinical Cancer Research, 2006, 12, 4018-4026.

Henning, S.M.; Aronson, W.; Niu, Y.; Conde, F.; Lee, N.H.; Seeram, N.P.; Lee, R.; Lu, J.; Harris, D.M.; Moro, A.; Hong, J.; Pak-Shan, L.; Barnard, R.J.; Ziaee, H.G.; Csathy, G.; Go, V.L.W.; Wang, H.; Heber, D. Bioavailability and bioactivity of tea polyphenols in human and mice prostate tissue and serum after green and black tea consumption. Journal of Nutrition, 2006, 136, 1839-1843.

Seeram, N.P.; Henning S.M.; Lee, R.; Niu Y.; Scheuller, H.S.; Heber, D. Catechin and caffeine contents of green tea dietary supplements and correlation with antioxidant activity. Journal of Agricultural and Food Chemistry, 2006, 54, 1599-1603. (Most accessed article for year 2006 in the Journal of Agricultural and Food Chemistry).

Adams, L.S.; Seeram, N.P.; Hardy, M.L.; Carpenter, C.; Heber, D. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cells. Evidence-Based Complementary and Alternative Medicine, 2006, 3, 117-124.

Adams, L.S.; Seeram, N.P.; Aggarwal, B.B.; Takada, Y.; Sand, D.; Heber, D. Pomegranate juice, total pomegranate tannins and punicalagin suppress inflammatory cell signaling in colon cancer cells. Journal of Agricultural and Food Chemistry, 2006, 54, 980-985. [Cited as ACS (American Chemical Society) Hot Papers: May 2007; As defined by Thomson ISI®'s Essential Science Indicators, Hot Papers are articles published within the last 2 years receiving the most citations over the most recent 2-month period].

Gao, K.; Xu, A.; Krull, C.; Venema, K.; Liu, Y.; Niu Y.; Lu, J.; Bensoussan, L.; Seeram, N.P.; Heber D.; Henning S.M. Of the major phenolic acids formed during human microbial fermentation of tea, citrus and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity. Journal of Nutrition, 2006, 136, 52-57.

Gao, K.; Henning, S.M.; Niu, Y.; Bensoussan, L.; Seeram, N.P.; Xu. A.; Heber, D. The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. Journal of Nutritional Biochemistry, 2006, 17, 89-95.

Seeram, N.P.; Lee, R.; Scheuller, H.S.; Heber, D. Identification of phenolics in strawberries by liquid chromatography electrospray ionization mass spectroscopy. Food Chemistry, 2006, 97, 1-11.

Li, Z.; Seeram, N.P.; Lee, R.; Thames, G.; Minutti, C.; Wang, H-J.; Heber, D. Plasma clearance of Lovastatin vs. Chinese Red Yeast Rice in healthy volunteers. Journal of Alternative and Complementary Medicine, 2005, 11, 1031-1038.

Loren, D.; Seeram, N.P.; Schulman, R.N.; Holtzman, D. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury, Pediatric Research, 2005, 57, 858-864.

Seeram, N.P.; Adams, L.S.; Henning, S.M.; Niu, Y.; Zhang, Y.; Nair, M.G.; Heber, D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. Journal of Nutritional Biochemistry, 2005,16, 360-367.

Seeram, N.P.; Lee, R.; Hardy, M.L.; Heber, D. Rapid large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Separation and Purification Technology, 2005, 41, 49-55.

Sartippour, M.R.; Seeram, N.P.; Heber, D.; Hardy, M.L.; Norris, N.; Lu, Q.L.; Zhang L.; Rao, J.Y.; Brooks, M.N. Rabdosia rubescens inhibits breast cancer growth and angiogenesis. International Journal of Oncology, 2005, 26, 121-127.

Seeram, N.P.; Lee, R.; Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta, 2004, 348, 63-68.

Tall, J.M.; Seeram, N.P.; Zhao, C.; Nair, M.G.; Meyer, R.A.; Raja, S.N. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behavioral Brain Research, 2004, 153, 181-88.

Seeram, N.P.; Adams, L.S.; Hardy, M.L.; Heber, D. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. Journal of Agricultural and Food Chemistry, 2004, 52, 2512-2517.

Beckwith, A.G.; Zhang, Y.; Seeram, N.P.; Cameron, A.C.; Nair, M.G. Relationship of light quantity and anthocyanin production in Pennisetum setaceum Cvs. Rubrum and Red Riding Hood. Journal of Agricultural and Food Chemistry, 2004, 52, 456-461.

Zhang, Y.; Bolleddula, J.; Seeram, N.P.; Olsen, L.K.; Dewitt, D.; Nair, M.G. Insulin secretion and cyclooxygenase enzyme inhibition by Cabernet Sauvignon grape skin compounds. Journal of Agricultural and Food Chemistry, 2004, 52, 228-233.

Cichewicz, R.H.; Zhang, Y.; Seeram, N.P.; Nair, M.G. Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies.  Life Sciences, 2004, 74, 1791-1799.

Bolleddula, J.; Zhang, Y.; Seeram, N.P.; Nair, M.G. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life Sciences, 2003, 174, 125-132.

Kang, S.Y.; Seeram, N.P.; Nair, M.G.; Bourquin, L.D. Tart cherry anthocyanins inhibit tumor development in ApcMin mice and reduce proliferation of human colon cancer cells, Cancer Letters, 2003, 194, 13-19.

Seeram, N.P.; Zhang, Y.; Nair, M.G. Inhibition of proliferation of human cancer cell lines and cyclooxygenase enzymes by anthocyanidins and catechins. Nutrition and Cancer, 2003, 46, 101-106.

Seeram, N.P.; Cichewicz, R.H.; Chandra, A.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. Journal of Agricultural and Food Chemistry, 2003, 51, 1948-1951.

Bolleddula, J.; Seeram, N.P.; Nair, M.G. Anticancer and anti-inflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Letters, 2003, 189, 11-16.

Seeram, N.P.; Francis, L.S.; Needham, O.L.; Jacobs, H.; McLean, S.; Reynolds, W.F. Drimane and bisabolane sesquiterpenoids from Cinnamodendron corticosum  (Canellaceae). Biochemical Systematics and Ecology, 2002, 31, 637-640.

Seeram, N.P.; Nair, M.G. Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents, anthocyanins, anthocyanidins and catechins. Journal of Agricultural and Food Chemistry, 2002, 50, 5308-5312.

Seeram, N.P.; Schutzki, R.; Chandra, A.; Nair, M.G. Characterization, quantification and bioactivities of anthocyanins in Cornus species, Journal of Agricultural and Food Chemistry, 2002, 50, 2519-2523.

Seeram, N.P.; Bourquin, L.D.; Nair, M.G. Degradation products of cyanidin glycosides from tart cherries and their bioactivities, Journal of Agricultural and Food Chemistry, 2001, 49, 4924-4929.

Seeram, N.P.; Momin, R.A.; Bourquin, L.D.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides from cherries and berries, Phytomedicine, 2001, 8, 362-369.

Jacobs, H.; Seeram, N.P.; Nair, M.G.; McLean, S.; Reynolds, W.F. Amides of Piper amalago var. nigrinodum. Journal of Indian Chemical Society, 2000, 76, 713-717.

Seeram, N.P.; Lewis, A.; Jacobs, H.; Nair, M.G.; McLean, S.; Reynolds, W.F. Proctoriones A-C: 2-acylcyclohexane-1,3-dione derivatives from Peperomia  proctorii. Journal of Natural Products, 2000, 63, 399-402.

Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F. A prenylated benzopyran derivative from Peperomia clusiifolia. Phytochemistry, 1998, 49, 1389-1391.

Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F. Prenylated hydroxybenzoic derivatives from Piper murrayanum. Phytochemistry, 1996, 43, 863-865.

Seeram, N.P.; Jacobs, H.; McLean, S.; Reynolds, W.F.; Tay, L.; Wu, M. 3,4-epoxydihydropiplartine. A new imide from Piper verrucosum. Journal of Natural Products, 1996, 59, 436-437.

 

Review & Symposium Introduction Articles in Peer-Reviewed Journals

Seeram, N.P. Berries and human health: Research highlights from the fifth biennial berry health benefits symposium, Journal of Agricultural and Food Chemistry, 2013, in press.

Seeram, N.P. Emerging research supporting the positive effects of berries on human health and disease prevention. Journal of Agricultural and Food Chemistry, 2012, 60, 5685-5686.  

Seeram, N.P. Recent trends and advances in berry health benefits research. Journal of Agricultural and Food Chemistry, 2010, 58, 3869-3870.

Seeram, N.P. Berry Fruits: Compositional elements, biochemical activities and the impact of their intake on human health, performance and disease. Journal of Agricultural and Food Chemistry, 2008, 56, 627-629. (Most accessed article for year 2008 in the Journal of  Agricultural and Food Chemistry).

Seeram, N.P. Berry fruits for cancer prevention: Current status and future prospects. Journal of Agricultural and Food Chemistry, 2008, 56, 630-635. (Most accessed article for Jan-Mar 2008 in the Journal of Agricultural and Food Chemistry).

Aggarwal, B.B.; Bhardwaj, A.; Aggarwal, R.S.; Seeram, N.P.; Shishodia, S.; Takada, Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research, 2004, 24, 2783-2840.

 

Book Chapters

Li, L.; Seeram, N.P. Chemical composition and biological effects of maple syrup. American   Chemical Society (ACS) Symposium Series Volume 1093, Emerging Trends in Dietary Components for Preventing and Combating Disease, Patil, B.; Murthy, K.N.C.; Jayaprakasha, G.K.; Seeram, N.P. (Eds), Oxford University Press, Washington DC, USA, 2012, Chapter 18, pp. 323-333.

Seeram, N.P. Polyphenol overview.  In: Encyclopedia of Dietary Supplements. Coates, P.; Betz,  J.M.; Blackman, M.R.; Cragg, G.M.; Levine, M.; Moss, J.; White, J.D. (Eds.). Informa Healthcare, New York, NY, USA, 2010, p.632.

Seeram, N.P.; Zhang, Y.; Bowerman, S.; Heber, D. Phytochemicals and health aspects of the pistachio. In: Tree Nut Nutraceuticals, Phytochemicals, and Health Aspects. Alasalvar, C.; Shahidi, F. (Eds). CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, 2009, pp. 295-304.

Seeram, N.P. Strawberry phytochemicals and human health: A review. In: Takeda, F., D.T. Handley, and E.B. Poling (Eds.). Proceedings of the 2007 North American Strawberry Symposium.  North American Strawberry Growers Association, Kemptville, ON, Canada, 2008. pp. 7-14.

Seeram, N.P.; Heber, D. Impact of berry phytochemicals on human health: Effects beyond antioxidation. Chapter 21. In: Lipid Oxidation and Antioxidants: Chemistry, Methodologies and Health Effects. American Chemical Society (ACS) Symposium Series No. 956/Antioxidant Measurement and Applications; Ho, C.T; Shahidi, F.S. (Eds). Oxford University Press, UK, 2006.

Aggarwal, B.B.; Bhatt, I.D.; Ichikawa, H.; Ahn, K.S.; Sethi, G.; Sandur, S.K.; Natarajan, C.; Seeram, N.P.; Shishodia, S.  Curcumin: Biological and medicinal properties. Chapter 10, pp. 297-368. In: Turmeric: The genus Curcuma. Ravindran, P.N.; Babu, K.N.; Sivaraman, K. (Eds.) CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.

Seeram, N.P.; Zhang, Y.; Reed, J; Krueger, C.; Vaya, J. Pomegranate phytochemicals. Chapter 1, pp. 3-30. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.

Espin, J.C.; Seeram, N.P.; Tomás-Barberán, F.A. Bioavailability of pomegranate polyphenols. Chapter 3, pp. 45-60. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.

Harris, D.M.; Besselink, E.; Seeram, N.P. Assessment of estrogenicity of pomegranate in an in vitro bioassay. Chapter 9, pp. 143-155. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal &Aromatic Plant Series, Boca Raton, FL, USA, 2006.

Seeram, N.P.; Zhang, Y.; Heber, D. Commercialization of pomegranates: Fresh fruits, beverages and botanical extracts. Chapter 12, pp. 187-196. In: Pomegranates: Ancient Roots Modern Medicine. Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). CRC Press & Taylor and Francis Group, Medicinal Aromatic Plant Series, Boca Raton, FL, USA, 2006.

Seeram, N.P. Berries. Chapter 37, pp. 615-625. In: Nutritional Oncology. Second Edition. Heber, D.; Blackburn, G.; Go, V.L.W.; Milner, J. (Eds). Academic Press, London, UK, 2006.

Seeram, N.P. Bioactive polyphenols from foods and dietary supplements: Challenges and opportunities. Chapter 3, pp. 25-38; In: Herbs: Challenges in Chemistry and Biology; ACS Symposium Series No. 925 (Herbs); Ho, C.T; Wang, M.; Sang, S. (Eds). Oxford University Press, UK, 2006.

Seeram, N.P.; Kulkarni, V.V.; Padhye, S. Sources and chemistry of resveratrol. Chapter 2, p. 17.

In: Oxidative Stress and Diseases: Resveratrol in Health and Disease. Aggarwal, B.B.; Shishodia, S.; Packer, L. (Eds). Taylor & Francis Group, Boca Raton, FL, USA, 2006.

Seeram, N.P.; Ichikawa, H.; Shishodia, S.; Aggarwal, B.B. Preventative and therapeutic effects of plant polyphenols through suppression of nuclear factor-kappa B. Chapter 21, pp. 243-275. In: Oxidative Stress and Diseases Series: Molecular Intervention in Lifestyle-Related Diseases. Hiramatsu, M.; Yoshikawa, T.; Packer, L. (Eds). CRC Press & Taylor and Francis Group, Boca Raton, FL, USA, 2006.

 

Book Editor & Book Series Editor

Patil, B.; Murthy, K.N.C.; Jayaprakasha, G.K.; Seeram, N.P. (Eds). American Chemical Society (ACS) Symposium Series, Emerging Trends in Dietary Components for Preventing and Combating Disease, American Chemical Society, Washington DC, distributed by Oxford University Press, 2012.

Stoner, G.; Seeram, N.P. (Eds). Berries and Cancer.  Springer Science, NY, USA, 2011.

  Seeram, N.P.; Schulman, R.N.; Heber, D. (Eds). Pomegranates: Ancient Roots Modern Medicine. CRC Press & Taylor and Francis Group, Medicinal & Aromatic Plant Series, Boca Raton, FL, USA, 2006.

Seeram, N.P. Clinical Pharmacognosy Series; CRC Press & Taylor and Francis Group, Boca   Raton, FL, USA, August 2008.  Volumes published in this series to date:

A) Bagetta, G.; Cosentino, M.; Corasaniti, M.T.; Sakurada, S. (Eds). Herbal Medicines: Development and Validation of Plant-Derived Medicines for Human Health. CRC Press & Taylor and Francis Group, Clinical Pharmacognosy Series, Boca Raton, FL, USA, 2012.

 

Patents

Seeram, N.P.; Heber D. Therapeutic uses of urolithins. US Patent No. 8,183,282, 2012.

Seeram, N.P.; Heber D. Purifications of pomegranate ellagitannins and their uses thereof. US Patent No. 7,897,791 B2, 2011.

Seeram, N.P.; Heber D. Purifications of pomegranate ellagitannins and their uses thereof. US Patent No. 7,919,636 B2, 2011.

Seeram, N.P.; Heber D.  Purifications of pomegranate ellagitannins and their uses thereof. US Patent No. 7,638,640 B2, 2009.

Nair, M.G.; Bourquin, L.D.; Seeram, N.P.; Kang, S.Y. Method for treating tumors caused by APC gene mutation with anthocyanins and cyanidin, US Patent No. 6,656,914 B2, 2003.

Nair, M. G.; Cichewicz, R.C.; Seeram, N.P.; Zhang, Y. Anticancer anthraquinones isolation from Hemerocallis fulva and methods of use. US Patent No. 6,875,746 B1, 2005.

Honors and Awards

2009 Young Scientist Award, Division of Agricultural and Food Chemistry, American Chemical Society.

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