Clinical Pharmacokinetics and Pharmacodynamics

Sara Rosenbaum, Ph.D.

Located in Lab Module 495 on Level 4 of Avedisian Hall

iMODR: Flash-Based Models and Videos

Interactive videos are useful for visualization processes in pharmacokinetics and pharmacodynamics.
2-Compartment Model
This video shows the relative distribution of a drug between the central and peripheral compartments from the time the dose is  injected up to the time the dose is eliminated from the body. It also shows how the drug’s volume of distribution changes over the same period.
 
 
 
Hysteresis

This video shows the time course of the plasma concentration and drug concentration at the site of action after an oral dose. It also shows how response is related to the plasma concentration (hysteresis curve) the concentration at the site of action.
The videos were created with the help of R. Wang and J. Connelly
 
 
Flash ® CS4 is a useful platform for the development of interactive pharmacokinetic and pharmacodynamic models. An interactive version of the Indirect Effect Model I- inhibition of kin, is shown below.
Interactive Indirect Effect Model I: Inhibition of kin
This model was created by Ruohan Wang as partial completion of her M.S. degree in Pharmaceutical Science.