Alan Shawn Feinstein College of Education and Professional Studies

80 Washington Street, Providence, RI 02903 – 401.277.5000

Normal Flow (Direct) Filtration

Course Outline

  • Fundamentals of normal flow filtration
  • Applications of filtration in a recombinant purification process:
    – Clarification
    – Prefiltration
    – Sterile filtration
    – Buffer filtration
    – Virus filtration
  • Types of membranes and media
  • Membrane Manufacturing methods
  • Types of membrane modules and cartridges
  • Fouling mechanisms
  • Vmax testing
  • Sizing of filters
    – based on throughput
    – based on flow rate
  • Integrity testing of filters
  • Practical tips on dos and don’ts
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