This model shows the typical plasma concentration profile associated with the administration of several doses of a drug over time. It demonstrates the determinants of the fluctuation in the plasma concentrations, the accumulation of the drug over the course of therapy and the resting steady state plasma concentrations.

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See Chapter 12: Multiple IV Bolus Injections in the One-Compartment Model
Topics relevant to this model are covered in the following sections:

– 12.8 Simulation Exercise

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  Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition

  By: Sara E. Rosenbaum, Ph.D.
  An Integrated Textbook with Computer Simulations, which provides a comprehensive account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.     

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