The model shows the unique plasma concentration-time profile associated with the administration of a drug using multiple short infusions. It demonstrates the influence of the duration of the infusion and allows the user to practice the calculation of a suitable dose and dosing interval to achieve desired peak and trough plasma concentrations of a drug.

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See Chapter 13: Multiple Intermittent Infusions
Topics relevant to this model are covered in the following sections:

– 13.5 Individualization of Dosing Regimens

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  Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition

  By: Sara E. Rosenbaum, Ph.D.
  An Integrated Textbook with Computer Simulations, which provides a comprehensive account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.     

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