A delay in response to a drug can occur when it takes a long time for the drug’s initial effect to be translated into the final response (a long transduction process). The delayed response profile can be captured using a series of transit compartments.
Link to Model
See Chapter 20: Semimechanistic PK-PD Models
Topics relevant to this model are covered in the following sections:
– 20.5 Other Indirect Effect Models
– 20.5.1 Transit Compartment
– 20.5.1.1 Simulation Exercise
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum
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