Overview

The Shen Lab (Advanced Drug Delivery & Bioengineering Research Laboratory) is specialized in the areas of formulation development, manufacturing, in vitro and in vivo product performance testing, and development of in vitro-in vivo correlation (IVIVC) for advanced drug delivery systems and medical devices. Located at the Kingston Campus of the University of Rhode Island, the Shen Lab is equipped with pharmaceutical fabrication and performance testing instruments, and a range of state-of-the-art scientific and manufacturing instrumentation through the RI-INBRE Centralized Research Core Facility and Pharmaceutical Development Institute (PDI).

Research

Targeted drug/gene delivery for the treatment of cancers and other human diseases

The overall goal of this line of research is to develop translational targeted therapeutics to minimize systemic toxicity and improve treatment of cancers and other human diseases.

Long acting injectable/implantable polymeric microspheres or hydrogels

We have been designing and developing complex parenteral drug products such as microspheres, nanoparticles, implants and hydrogels as a means to deliver therapeutics in a controlled manner over periods of days to months.

In vitro release testing methods and in vitro-in vivo correlation (IVIVC) for complex drug products

My team has been working on the design and development of suitable discriminatory in vitro release methods for various complex drug products including polymeric microspheres, in situ forming implants and hydrogels. In addition, I have been working on the development of IVIVC to facilitate the development of both innovative and generic complex drug products.

Pediatric formulations with improved efficacy and patience compliance

The main purposes of this study are to: i) Develop innovative technologies and platforms for child-friendly, easy-to-swallow, and palatable oral pediatric formulations with improved efficacy; and ii) Develop novel nanotherapeutics or devices with application in pediatrics.

Publications

Peer-Reviewed Articles (* Corresponding Author)

1. Shah N, Ivone R, Shen J, Meenach SA. Comparison of Nanoparticle Purification Process via Centrifugation and Tangential Flow Filtration: A Case Study on Acetalated Dextran Nanoparticles. Particuology, 2019. (In press)
2. Andhariya JV, Shen J, Wang Y, Choi S, Burgess DJ. Effect of minor manufacturing changes on stability of compositionally equivalent PLGA microspheres. International Journal of Pharmaceutics. 2019, 566: 532-40.
3. Yang Y, Zheng N, Wang XY, Ivone R, Shan WG,* Shen J.* Rapid preparation of spherical granules via the melt atomization technique. Pharmaceutics. 2019, 11(5): 198.
4. Yang Y, Li H, Xu Y, Dong YC, Shan WG,* Shen J.* Fabrication and evaluation of dental fillers using customized molds via 3D printing technology. International Journal of Pharmaceutics. 2019, 563: 66-75.
5. Yang Y, Zheng N, Li HC, Shan WG,* Shen J.* Mechanistic study on rapid fabrication of fibrous films via centrifugal melt spinning. International Journal of Pharmaceutics. 2019, 560: 155-65.
6. Shen J,* Burgess DJ. Advances in drug delivery related biosensors and medical devices. International Journal of Pharmaceutics. 2018, 544(2): 307-8.
7. Li Z, Xie J, Peng S, Liu S, Wang Y, Lu WY, Shen J, Li C. Novel strategy utilizing extracellular cysteine-rich domain of membrane receptor for constructing d-peptide mediated targeted drug delivery systems: a case study on Fn14. Bioconjugate Chemistry.2017, 28(8): 2167-79.
8. Bao QY, Shen J, Jog R, Zhang C, Newman B, Wang Y, Choi S, Burgess DJ. In vitro release testing method development for ophthalmic ointments. International Journal of Pharmaceutics. 2017, 526(1-2): 145-56.
9. Andhariya JV, Shen J, Choi S, Wang Y, Zou Y, Burgess DJ. Development of in vitro-in vivo correlation of parenteral naltrexone loaded polymeric microspheres. Journal of Controlled Release. 2017, 255: 27-35.
10. Bao QY, Jog R, Shen J, Newman B, Wang Y, Choi S, Burgess DJ. Physicochemical attributes and dissolution testing of ophthalmic ointments. International Journal of Pharmaceutics. 2017, 523(1): 310-19.
11. Andhariya JV, Choi S, Wang Y, Zou Y, Burgess DJ, Shen J.* Accelerated in vitro release testing method for naltrexone loaded plga microspheres. International Journal of Pharmaceutics. 2017, 520(1-2): 79-85. Prior to URI
12. Suh MS, Shen J, Kuhn L, Burgess DJ. Novel nanoparticle platform for targeted cancer therapy. International Journal of Pharmaceutics. 2017, 517(1-2): 58-66. 
    

    ---

    Prior to URI

13. Jog R, Kumar S, Shen, Jugade N, Tan DC, Gokhale R, Burgess DJ. Formulation design and evaluation of amorphous ABT-102 nanoparticles. International Journal of Pharmaceutics. 2016, 498(1-2): 153-69.
14. Shen J, Lee K, Choi S, Qu W, Wang Y, Burgess DJ. A reproducible accelerated in vitro release testing method for plga microspheres. International Journal of Pharmaceutics. 2016, 498(1-2): 274-82.
15. Shen J, Choi S, Qu W, Wang Y, Burgess DJ. In vitro-in vivo correlation of parenteral risperidone polymeric microspheres. Journal of Controlled Release. 2015, 218: 1-12. (Selected as the Editorial Cover Story and Cover Page)
16. Shen J, Burgess DJ. In vitro-in vivo correlation for complex non-oral drug products: where do we stand? Journal of Controlled Release. 2015, 219: 644-51.
17. Kumar S, Shen J, Zolnik B, Sadrieh N, Burgess DJ. Optimization and dissolution performance of spray-dried naproxen nano-crystals. International Journal of Pharmaceutics. 2015, 486(1-2): 159-66.
18. Kumar S, Jog R, Shen J, Zolnik B, Sadrieh N, Burgess DJ. Formulation and performance of danazol nano-crystalline suspensions and spray dried powders. Pharmaceutical Research. 2015, 32(5): 1694-703.
19. Kumar S, Jog R, Shen J, Zolnik B, Sadrieh N, Burgess DJ. In vitro and in vivo performance of different sized spray-dried crystalline itraconazole. Journal of Pharmaceutical Sciences. 2015, 104(9): 3018-28.
20. Kumar S, Shen J, Burgess DJ. Nano-amorphous spray dried powder to improve oral bioavailability of itraconazole. Journal of Controlled Release. 2014, 192C: 95-102.
21. Shen J, Yu M, Meng QG, Li J, Lv YF, Lu WY. Fatty acid-based strategy for efficient brain targeted gene delivery. Pharmaceutical Research. 2013, 30(10): 2573-83.
22. Shen J, Burgess DJ. In vitro dissolution testing strategies for nanoparticulate drug delivery systems: recent developments and challenges. Drug Delivery and Translational Research. 2013, 3(5): 409-15.
23. Li Y, Lei Y, Wagner E, Xie C, Lu WY, Zhu JH, Shen J, Wang J, Liu M. Potent retro-inverso d-peptide for simultaneous targeting of angiogenic blood vasculature and tumor cells. Bioconjugate Chemistry. 2013, 24(1): 133-43.
24. Shen J, Burgess DJ. Accelerated in vitro release testing methods for extended release parenteral dosage forms. Journal of Pharmacy and Pharmacology. 2012, 64(7): 986-96.
25. Li C, Shen J, Wei X, Xie C, Lu WY. Targeted delivery of a novel palmitylated d-peptide for anti-glioblastoma molecular therapy. Journal of Drug Targeting. 2012, 20(3): 264-71.
26. Shen J, Burgess DJ. Accelerated in vitro release testing of implantable PLGA microsphere/PVA hydrogel composite coatings. International Journal of Pharmaceutics. 2012, 422(1-2): 341-8.
27. Li C, Shen J, Lu WY. Mirror-image isomers screening: overcoming the enzyme barriers for the development of peptide and oligonucleotide therapeutics. Science China Chemistry. 2011, 41: 1112-20.
28. Jin XF, Xu Y, Shen J, Ping QN, Su Z, You WL. Chitosan-glutathione conjugate-coated poly (butyl cyanoacrylate) nanoparticles: promising carriers for oral thymopentin delivery. Carbohydrate Polymers. 2011, 86(1): 51-7.
29. Shen J, Zhan CY, Xie C, Meng QG, Gu B, Li C, Zhang Y, Lu WY. Poly(ethylene glycol)-block-poly(d,l-lactic acid) micelles anchored with angiopep-2 for brain-targeting delivery. Journal of Drug Targeting. 2011, 19(3): 197-203. (Selected as the Key Article by the Editor-in-Chief).
30. Shen J, Deng YP, Jin X, Ping QN, Su Z, Li L. Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for Cyclosporine A: improving in vivo ocular distribution. International Journal of Pharmaceutics. 2010, 402(1-2): 248-53.
31. Sun MJ, Wang Y, Shen J, Ping QN. Octreotide-modification enhances the delivery and targeting of doxorubicin-loaded liposomes to somatostatin receptors expressing tumor in vitro and in vivo. Nanotechnology. 2010, 21(47): 475101.
32. Shen J, Sun MJ, Ping QN. Incorporation of liquid lipid in lipid nanostructured carriers for ocular drug delivery enhancement. Nanotechnology. 2010, 21(2): 025101.
33. Shen J, Wang Y, Ping QN. Mucoadhesive effect of thiolated peg stearate and its modified NLC for ocular drug delivery. Journal of Controlled Release. 2009, 137(3): 217-23.
34. Ping QN, Shen J, Wang Y. Recent progress in cell penetrating peptides. Journal of China Pharmaceutical University. 2006, 37(suppl): 53.
35. Shen J, Luan LB. Preparation and characterization of diammonium glycyrrhizinate liposomes. Chinese Journal of New Drugs. 2006, 15(5): 361.
36. Guo JX, Wu T, Ping QN, Chen Y, Shen J, Jiang G. Solubilization and pharmacokinetic behaviors of sodium cholate/lecithin-mixed micelles containing Cyclosporine A. Drug Deliv 2005, 12(1): 35-39.

Patents

1. Lu WY, Shen J, et al. One pH-sensitive dual-stage brain tumor targeted drug delivery system and nanoparticle preparation method and application. (CN103656650B)
2. Ping QN, Wang Y, Sun MJ, Shen J. PEG-decorated phospholipid derivative using octreotide as target ligand and production method thereof. (CN101455845B)
3. Ping QN, Shen J, Sun MJ, et al. Biological adhesion-type poly(ethylene glycol) derivative and application thereof in pharmacology. (CN101544756A)

Book Chapters                                                                                    

• Shen J, Burgess DJ. Drugs for Long Acting Injections and Implants. In “Long Acting Injections and Implants”. Eds. Wright J and Burgess DJ. CRS Press, Springer, 2012: 73-91.

Full publication list:

https://scholar.google.com/citations?hl=en&user=mb6wgDkAAAAJ&view_op=list_works

Research Team

Principle Investigator

Jie Shen, Ph.D.

Assistant Professor                                           

Biomedical and Pharmaceutical Sciences & Chemical Engineering

Positions Available 

Dr. Jie Shen’s laboratory in the Departments of Biomedical and Pharmaceutical Sciences at URI welcome motivated and talented individuals to join the Shen Lab as a graduate or an undergraduate researcher.

If interested, please send your CV and unofficial transcripts to Dr. Shen at jie_shen@uri.edu

Lab Members

Lingxiao Xie, Ph.D.

Postdoctoral Fellow                                           

Biomedical and Pharmaceutical Science

Ryan Ivone, M.S.

Ph.D. Student           

Biomedical and Pharmaceutical Science

Khaled Ibrahim

M.S. Student 
Biomedical and Pharmaceutical Science 

Yanping Deng, Ph.D.

Visiting Scholar
Biomedical and Pharmaceutical Sciences

Outreach

Our lab and other Chemical Engineering labs have partnered with a local high school to run a K12 outreach program known as the Rhode Island Pharmaceutical and Biological Engineering Academy (RIPBEA). The RIPBEA program runs every spring semester and features interactive lectures/seminars at the high school, facility tours and hands-on laboratory experience at URI, as well as poster presentations detailing students’ activities.

Jie Shen, Ph.D.

• Assistant Professor 
• Phone: 401.874.5594
• Email: jie_shen@uri.edu