1. Present the structure of a PD model for the hematological toxicty 2. Observe the onset, duration of, and recovery from, drug-induced neutropenia 3. Observe how a drug’s PK and PD effects the duration and intensity of neutropenia

1. Understand how irreversible drug effects can be modeled 2. Observe the time course of plasma concentrations and response 3. Using a simulation model based on disolvprazole (see text), observe how     irreversible drug effects impact the design of dosing regimens