- Assistant Professor
- Biomedical and Pharmaceutical Sciences, George & Anne Ryan Institute for Neuroscience
- Phone: 401.874.5545
- Email: jaime_ross@uri.edu
- Website
Biography
Jaime M. Ross, Ph.D. joined the URI Faculty in October 2019 and is an Assistant Professor of Neuroscience within the George and Anne Ryan Institute for Neuroscience and Biomedical and Pharmaceutical Sciences in the College of Pharmacy. Dr. Ross is a native of Southern Vermont and attended Saint Lawrence University, where she studied Neuroscience and Fine Arts. Dr. Ross obtained her Ph.D. in Medical Sciences in the Department of Neuroscience at Karolinska Institutet in Stockholm, Sweden, in collaboration with the National Institutes of Health Graduate Partnerships Program. Thereafter, she completed post-doctoral training at both Karolinska Institutet and Harvard Medical School.
Dr. Ross’s overall research interests are to use genetic and genomic approaches to understand the basic mechanisms of disease, focusing on aging and age-related diseases, and in particular brain aging disorders such as Alzheimer’s and Parkinson’s disease. Her lab is most interested in understanding the interconnectedness of mitochondrial dysfunction, epigenetics, and chronic inflammation in aging and disease states in order to develop novel biomarkers and therapies.
Dr. Ross has made seminal contributions to understanding the aging process and is author to more than 20 publications. Her research accomplishments have led to several noteworthy awards and fellowships, including a K99/R00 award from the National Institute on Aging. She also has served as Guest Editor and is on the Editorial Board of Frontiers in Aging Neuroscience, Experimental Gerontology, and International Journal of Molecular Sciences. Outside of the laboratory, Dr. Ross enjoys experimenting in the kitchen as well as in her art studio.
Research
The Ross Lab investigates fundamental questions of aging. Our primary objectives are directed toward understanding the metabolic consequences and underlying molecular mechanisms of aging and age-related diseases, with a particular focus on brain aging and neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. Our work investigates the interconnectedness of several hallmarks of the aging process: mitochondrial dysfunction, deregulated gene expression (epigenetic alterations), and “inflammaging” (low, chronic inflammation), focusing on the whole body as well as key brain regions and neuronal populations.
Education
Post-doctoral Fellow, Harvard University Medical School, 2015-2019
Post-Doctoral Fellow, Karolinska Instiutet, Stockholm, Sweden, 2013-2019
Ph.D., Neuroscience, Karolinska Institutet (National Institutes of Health – Karolinska Institutet Graduate Partnerships Program), 2012
Pre-doctoral Fellow, Karolinska Institutet, Stockholm, Sweden, 2007-2012
B.S., Neuroscience and Fine Arts, St. Lawrence University, 2003
Selected Publications
Potts E†, Coppotelli G, Ross JM#. (2020) Histological-based stainings using free-floating method. Journal of Visualized Experiments. DOI: 10.3791/61622. PubMed
Adelöf J, Ross JM, Lazic SE, Zetterberg M, Wiseman JW, Hernebring M. (2019). Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan. Aging,Sep 11;11(17):7150-7168. PubMed
Ross JM♯, Coppotelli G♯,Branca RM, Kim KM†, Lehtiö J, Sinclair DA, Olson L. (2019). Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice. Aging Cell, Dec;18(6):e13029. PubMed
Ross JM, Coppotelli G, Olson L (Eds). (2016).Mitochondrial Dysfunction in Ageing and Diseases. International Journal of Molecular Sciences. Basel: MDPI AG.ISBN: 978-3-03842-251-8
Coppotelli G, Ross JM♯.(2016). Mitochondria in Ageing and Diseases: The Super Trouper of the Cell. International Journal of Molecular Sciences, Special Issue, “Mitochondrial Dysfunction in Ageing and Diseases”. 17(5):711. DOI: PubMed (invited Editorial)
Ross JM♯, Olson L, Coppotelli G#. (2015). The Mitochondrial and Ubiquitin Proteasome Systems in ageing and disease: Two sides of the same coin? International Journal of Molecular Sciences, Special Issue, “Mitochondrial Dysfunction in Ageing and Diseases”. 16(8):19458-76. DOI:10.3390/ijms160819458 PubMed(invited review)
Ross JM♯, Coppotelli G, Hoffer BJ, Olson L. (2014). Maternally transmitted mtDNA mutations cause reduced lifespan. Scientific Reports,4, 6569; DOI:10.1038/srep06569. PubMed
Ross JM, Stewart JB, Hagström E, Brené S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson NG. (2013). Germline mtDNA mutations aggravate ageing and can impair brain development. Nature, Sep 19; 501(7467): 412-5. PMID:23965628 PubMed
Ross JM♯. (2011). Visualization of mitochondrial respiratory function using cytochrome c oxidase / succinate dehydrogenase (COX/SDH) double-labeling histochemistry. Journal of Visualized Experiments, (57): e3266, DOI: 10.3791/3266.PMID: 22143245 PubMed(invited by Editor)
Ross JM♯, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ and Olson L. (2010). High brain lactate is a hallmark aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proceedings of the National Academy of Sciences of the United States of America, Nov 16; 107(46): 20087-92. PMID: 21041631 PubMed
(† indicates trainees)
(# indicates corresponding author)