Roberta King, Ph.D.

Roberta King, Ph.D.
  • Professor
  • Office: 495L Lab: 320
  • Phone: 401.874.7061
  • Email: rking@uri.edu
  • Office Location: Avedisian Hall, 7 Greenhouse Road, Kingston, RI 02881
Research Website

 

Research

Metabolism & enzymology of endo- and xenobiotics (including medications, hormones, neurotransmitters, dietary substances); Variation in metabolism caused by disease state, age, genetic polymorphisms and presence of inhibitor/activators/suppressors/activators; Protein structure bioinformatics and drug design.

Education

Post-doctoral Fellow, Molecular Epidemiology, National Center for Toxicological Research, 1995-1999
Ph.D., Medicinal and Natural Products Chemistry, University of Iowa, 1995
B.S., Chemistry, University of Kansas, 1989

Selected Publications

Wen X, Donepudi AC, Thomas PE, Slitt AL, King RS, *Aleksunes LM (2012) Regulation of hepatic phase-II metabolism in pregnant mice. J Pharmacol Exp Ther. 2012 Oct 10. [Epub ahead of print] PMID:23055538.

*Pichu, S, Yalcin, EB, Ribeiro, JM, King, RS and Mather, TN. Molecular Characterization of Novel Sulfotransferases from the Tick, Ixodes scapularis. BMC Biochemistry, 12:32. PMID 21708020 (2011). http://www.biomedcentral.com/1471-2091/12/32

Yalcin, EB, Stangl,H, Pichu, S, Mather, TM, *King, RS. Monoamine Neurotransmitters as Substrates for Blacklegged Tick Sulfotransferases. Homology Modeling, Molecular Docking, and Enzyme Kinetics. ACS Chemical Biology, 6(2):176-184 (2011). Epub 2010 Nov 15. PMID: 21043483. http://0-pubs.acs.org.helin.uri.edu/doi/abs/10.1021/cb100266g

Kaimal, R, Song, X, Yan, B, King, R, and *Deng, R Differential Modulation of Farnesoid X Receptor Signaling Pathway by the Thiazolidinediones J. Pharmacol. Exp. Ther. 330: 125-134 (2009). PMID: 19369578. (http://www.ncbi.nlm.nih.gov/pubmed/19369578)

Yalcin, EB, Struzik, SM, *King, RS. Allosteric modulation of SULT2A1 by celecoxib and nimesulide: Computational analyses. Drug Metabolism Letters, 2(3):198-204 (2008). PMID: 19356094. (http://www.ingentaconnect.com/content/ben/dml/2008/00000002/00000003/art00010) http://www.ncbi.nlm.nih.gov/pubmed/19356094

Yuan, Z, Jha, G, McGregor, M, and *King, RS. Metabolites of the carcinogen 2-amino-alpha-carboline formed in male Sprague-Dawley rats in vivo, and in rat hepatocyte and human HepG2 cell incubates. Chemical Research in Toxicology, 20:497-503 (2007). PMID: 17291013. (http://www.ncbi.nlm.nih.gov/sites/entrez/17291013)

*King, RS, Ghosh AA, Wu, J. Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Current Drug Metabolism, 7(7):745-753 (2006). PMID: 17073578. (http://www.ncbi.nlm.nih.gov/sites/entrez/17073578)

Banoglu, E and *King, RS. Sulfation of indoxyl by human and rat aryl (phenol) sulfotransferases to form indoxyl sulfate. European Journal of Drug Metabolism and Pharmacokinetics, 27(2): 135-140 (2002). PMID: 12064372. (http://0-www.ncbi.nlm.nih.gov.helin.uri.edu/pubmed/12064372)