Metabolism & Enzymology Research

Roberta King, Ph.D.

Located in Lab Module 470 on Level 4 of Avedisian Hall

Our research program at URI can be described by four related projects:

  1. Inhibitors of human sulfotransferases
  2. Biotransformation of indole to the uremic toxin indoxyl sulfate
  3. In vivo metabolism of the food-borne carcinogen 2-amino-alpha-carboline
  4. Effect of sulfotransferase inhibitors on estradiol homeostasis and   actions

We have two additional collaborative projects:

  1. Metabolism of benzo[ghi]pyrene (Bongsup Cho)
  2. Metabolism of linolenic acid in salmon liver hepatocytes (Chong Lee, Nutrition)

These projects all emanate from my expertise in biochemical and toxicological approaches toward metabolism of drugs, hormones, carcinogens, and other xenobiotics. My training includes chemistry, biochemistry, enzymology, toxicology and pharmacology, and I tend to see the world of science through the eyes of biochemistry and enzymology. This is reflected in my approach toward research.