This is the model that is most commonly used to for the time course of drug effects in man. It assumes that the response is driven by the blood or plasma concentrations of the drug. When the model parameters are known, it can be used to predict response at anytime time after any dose.
Link to Model
See Chapter 19: Introduction to PD Models and Integrated PK-PD Models
Topics relevant to this model are covered in the following sections:
– 19.3 Direct Effect Pharmacodynamic Models
– 19.4 Integrated PK-PD Models: Integrated Bolus Injection in a 1 Compartment Model and the Sigmoidal Emax Model
– 19.4.1 Simulation Exercise
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum
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