Model 2: Simple Drug Transporter Model

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The major uptake and efflux transporters present in the intestinal, hepatocyte and renal tubular membranes are shown. Examples of transporters at the various sites can be seen by clicking on a transporter symbol. The model will simulate plasma concentrations after oral or IV doses. Individual transporters may be turned off to observe how they influence drug concentrations.

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See Chapter 2: Passage of Drugs Through Membranes
Topics relevant to this model are covered in the following sections:

– 2.4.1 Uptake Transporters: SLC Superfamily
– 2.4.2 Efflux Transporters: ABC Superfamily
– 2.4.3 Characteristics of Transporter Systems
– 2.4.4 Simulation Exercise

 

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