This model demonstrates how an effect compartment can be added to a pharmacokinetic model to accommodate a delay in drug response caused by a slow distribution of a drug to its site of action.
Link to Model
See Chapter 20: Semimechanistic PK-PD Models
Topics relevant to this model are covered in the following sections:
– 20.2 Hysteresis and the Effect Compartment
– 20.2.1 Simulation Exercise
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum
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