Some drugs do not directly produce the measured drug response. Instead they act upstream, and either increase or decrease the amount of the entity that directly mediates the response (response variable). Indirect effect Model IV can be used for drugs that stimulate the degradation of the response variable. As a result they decrease the amount of the response.
See Chapter 20: Semimechanistic PK-PD Models
Topics relevant to this model are covered in the following sections:
– 20.4 Indirect Effect Models
– 20.4.1 Introduction
– 20.4.2 Characteristics of Indirect Effect Drug Response
– 20.4.3 Characteristics of Indirect Effect Models Illustrated Using Model I
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum