This model shows the typical effect of several anticancer drugs on the number of circulating neutrophils. The drugs destroy neutrophils as they develop in the bone marrow, and its takes several days for their action to effect the circulating neutrophils. The model demonstrates how inter-individual variability in pharmacokinetics and pharmacodynamics can affect the magnitude and duration of this response.
Link to Model
See Chapter 20: Semimechanistic PK-PD Models
Topics relevant to this model are covered in the following sections:
– 20.5 Other Indirect Effect Models
– 20.5.2 Model for Hematological Toxicity of Anticancer Drugs
– 20.5.2.1 Simulation Model
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum
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