Model 3: Hepatic Clearance Model

See Chapter 5: Drug Elimination and Clearance
Topics relevant to this model are covered in the following sections:

– Hepatic Clearance and the Well Stirred Venous Equilibrium Model
– Hepatic Bioavailability
– Hepatic Oral Clearance
– Sensitivity to Changes in Q, Clint, fu

* High Extraction: Nonrestrictive Clearance
* Low Extraction: Restrictive Clearance
* Drugs with Mid-Range Extraction Ratios

– Simulation Model For Hepatic Clearance


  • cholab

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