Model 5: Single Injection in a 2-Compartment Model

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This model shows how a drug’s plasma concentration changes over time after an intravenous injection. It presents the drug-specific parameters that control this relationship. The two compartment model assumes drug distribution to some of the tissues occurs more slowly.

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See Chapter 8: PK of an IV Injection in a Two-Compartment Model
Topics relevant to this model are covered in the following sections:

– 8.6 Simulation Exercise

 

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    Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition

    By: Sara E. Rosenbaum, Ph.D.
    An Integrated Textbook with Computer Simulations, which provides a comprehensive account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.     

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