This model shows the characteristics of a single oral dose with first order absorption in a one compartment model. The model demonstrates the determinants of the peak plasma concentration, the time to reach the peak and area under the curve. Additionally the model illustrates how absorption, and not elimination controls the fall in the plasma concentration when absorption is very slow (Flip flop model).

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See Chapter 9: PK of Extravascular Drug Administration
Topics relevant to this model are covered in the following sections:

– 9.6 Simulation Exercise

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  Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition

  By: Sara E. Rosenbaum, Ph.D.
  An Integrated Textbook with Computer Simulations, which provides a comprehensive account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.     

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