This model shows the plasma concentration profile associated with constant continuous drug administration. Examples of this type of administration include the IV infusion, certain oral formulations and certain transdermal patches. The model demonstrates the determinants of the steady state plasma concentration, the time to reach steady state, the administration of loading doses, and the fall in plasma concentrations when drug administration is stopped.

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See Chapter 11: PK of IV Infusion in a One-Compartment Model
Topics relevant to this model are covered in the following sections:

– 11.2.3 Simulation Exercise: Part 1 Rate of Infusion and Cpss
– 11.2.3 Simulation Exercise: Part 2 Effect of Cl and Vd on Cpss
– 11.4.3 Simulation Exercise: Part 3 The Loading Dose
– 11.5.2 Simulation Exercise: Part 4 Termination of the Infusion

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  Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition

  By: Sara E. Rosenbaum, Ph.D.
  An Integrated Textbook with Computer Simulations, which provides a comprehensive account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.     

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