Many aromatic amines are environmental toxins and human carcinogens. They damage genome and form different bulky DNA lesions, which give rise to different mutation patterns. This application will study the mutational spectra of bulky DNA lesions generated from aromatic amine exposure and provide insights into the development of tumors. Project Summary Many environmental toxins damage […]
Continue reading "Mutational spectra of bulky DNA lesions (NIEHS 5R01ES028865) in collaboration with Dr. Deyu Li (PI) at The University of Rhode Island"Author: Ian T Lester
Protein binding of per- and polyfluoroalkyl substances (PFASs) as part of URI/Harvard Superfund STEEP (NIH/NIEHS 3P42ES027706)
Per- and polyfluoroalkyl substances (PFASs) are used to make surfaces water and oil resistant and can be found in cookware and fabric, as well as firefighting foam. They are ubiquitous and are contaminating water supplies near manufacturing plants and fire training sites. PFASs are present in blood serum of 99% of human population worldwide. To […]
Continue reading "Protein binding of per- and polyfluoroalkyl substances (PFASs) as part of URI/Harvard Superfund STEEP (NIH/NIEHS 3P42ES027706)"Hit the Streets
On a clear and cold Tuesday evening in February a small, slight figure walks a busy city street in Rhode Island’s capital city of Providence, approaching strangers most would go out of their way to avoid. Nicole Schwab who will graduate with a Doctor of Pharmacy degree in May is there to offer help to the homeless: […]
Continue reading "Hit the Streets"Senior Health Insurance Program (SHIP)
Volunteers provide seniors with information, counseling, and assistance in making decisions about Medicare and other insurance concerns.
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A website and mobile app that tracks prescription drug prices and offers discount coupons.
Continue reading "GoodRx"Grant funds purchase of cutting-edge drug manufacturing equipment
$146,000 grant to buy instruments for new class on topicals development.
Continue reading "Grant funds purchase of cutting-edge drug manufacturing equipment"Ryan Institute Gets Approval for Groundbreaking Alzheimer’s Clinical Trial
College of Pharmacy’s Pharmaceutical Development Institute plays key role in trial.
Continue reading "Ryan Institute Gets Approval for Groundbreaking Alzheimer’s Clinical Trial"Clinical Pharmacokinetics and Pharmacodynamics (Rosenbaum)
Dr. Rosenbaum is applying modeling and simulation of drug response data as tools to more fully understand the time course and intensity of drug effects in man. She is interested in applying these methods in research to obtain a greater understanding of a drug’s properties in different populations.
Continue reading "Clinical Pharmacokinetics and Pharmacodynamics (Rosenbaum)"Include: Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum, Ph.D.
An Integrated Textbook with Computer Simulations, which provides a comprehensive account of essential pharmacokinetic and pharmacodynamic concepts. The textbook also incorporates interactive pharmacokinetic and pharmacodynamic simulation models to allow students to visualize important principles and experiment with the design of drug dosing regimens.
Chemical Carcinogenesis Research (Cho)
Our research area is in chemical carcinogenesis with a major emphasis on the structural and synthetic aspects of DNA-adduct formation. Aromatic amine and polycyclic aromatic hydrocarbons are present in environment, thereby posing a threat to human health. I am particularly interested in how environmental carcinogens, upon metabolism, interact with cellular DNA and initiate mutagenesis/carcinogenesis. The […]
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