Aromatic amines are among the most notorious environmental chemicals. At pathologically relevant concentrations, their reactive metabolites can react with cellular DNA to produce bulky lesions. If not efficiently repaired, these lesions can result in mutations that lead to various sporadic cancers. Understanding the mechanisms by which these lesions are recognized by the XPC nucleotide excision […]

Many aromatic amines are environmental toxins and human carcinogens. They damage genome and form different bulky DNA lesions, which give rise to different mutation patterns. This application will study the mutational spectra of bulky DNA lesions generated from aromatic amine exposure and provide insights into the development of tumors. Project Summary Many environmental toxins damage […]

Per- and polyfluoroalkyl substances (PFASs) are used to make surfaces water and oil resistant and can be found in cookware and fabric, as well as firefighting foam. They are ubiquitous and are contaminating water supplies near manufacturing plants and fire training sites.  PFASs are present in blood serum of 99% of human population worldwide. To […]