Deng Lab

Dr. Deng’s research program is primarily focused on investigating bile acid and cholesterol homeostasis under physiological and pathological conditions. Disruption of bile acids and cholesterol homeostasis by genetic or environmental factors has been associated with various diseases.

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Arylamine DNA adduct recognition in eukaryotic nucleotide excision repair (NIH/NIEHS 5R21 ES028384) in collaboration with Dr. Jung Hyun Min at Baylor University

Aromatic amines are among the most notorious environmental chemicals. At pathologically relevant concentrations, their reactive metabolites can react with cellular DNA to produce bulky lesions. If not efficiently repaired, these lesions can result in mutations that lead to various sporadic cancers. Understanding the mechanisms by which these lesions are recognized by the XPC nucleotide excision […]

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