This is the fourth in a series of five models on pharmacokinetic-based drug-drug interactions (DDI). It uses the TDI of the metabolism of desimpranine by paroxetine as a background to study the impact of the inhibitor’s KI, kinact and [I], the victim’s fm and the enzymes kdegrad on the plasma concentration, PK parameters and AUCR of the victim drug.
Link to Model
See Chapter 17: Models Used to Predict DDIs For Orally Administered Drugs
Topics relevant to this model are covered in the following sections:
– 17.4.3 Predictive Models Incorporating Parallel Pathways of Elimination (fm)
– 17.4.3.1 AUC and fm
– 17.4.3.3 Models For Time-Dependent Inhibitors
Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations 2nd Edition
By: Sara E. Rosenbaum
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