Mass Spectrometry

LC/Mass Spectrometers

 

AB SCIEX TripleTOF 4600 system

The AB SCIEX TripleTOF 4600 system includes a mass spectrometer, a DuoSpray™ ion source, and a computer running the Analyst TF software. The DuoSpray ion source combines a Turbo Ion Spray (TSI) probe and an APCI (atmospheric pressure chemical ionization) probe in a single ion source housing.
Unique features include: increased sensitivity with QJet Ion Guide and Accelerator TOF Anayzer;  SmartSpeed 100Hz Acquisition; select up to 50 precursors and get high resolution MS/MS results using IDA (information-dependent acquisition) algorithms.


AB SCIEX QTrap 4500 system

The AB SCIEX QTrap 4500 system includes a triple quadrapole nominal-mass mass spectrometer, Turbo V ion source, and computer running Analyst software. The instrument also contains a QJet Ion Guide for increased sensitivity.

 

 

 

AB SCIEX TripleTOF 5600 system

The AB SCIEX TripleTOF 5600 system includes a mass spectrometer, a DuoSpray™ ion source, a High frequency LINAC® Collision Cell, an Accelerator TOF Analyzer, a Detection system, and a computer running the Analyst TF 1.7.1 software. Key features include enhanced selectivity with differential ion mobility, robust spray with the DuoSpray™ Turbo V Source, comprehensive coverage with data-independent SWATH acquisition, and maximize flexibility with front end separations. The AB SCIEX TripleTOF 5600 system is coupled to an Acquity UPLC H-Class system for chromatographic separation.

 

The Shimadzu Prominence UFLC system

Both mass spectrometers have Shimadzu Prominence UFLC systems which provides 10 times faster separation than conventional LC with a reduction of total analysis cycle time and three times better separation.

 

 

 

 

Elemental Analyzer (ICP-MS)

The iCAP Q ICP-MS has been developed with groundbreaking technology to enable advanced high-performance analysis combined with total reliability and ultra-flexibility.

  • Ergonomically designed quadrupole ICP-MS with smallest bench space available
  • Innovative RAPID (Right Angle Positive Ion Deflection) lens technology (90° ion optics done right) for separation of ions and neutrals
  • High-performance quadrupole analyzer is pumped by a novel split flow turbo pump backed by a single rotary
  • New, simultaneous analog/PC detector with real time multi-channel analyzer  electronics provides >9 orders of dynamic range suitable for both steady state and transient signal analysis

 

MALDI TOF/TOF Mass Spectrometer
The AXIMA Performance is a MALDI-TOF/TOF instrument with a 50Hz nitrogen laser, up to 384 sample target capability and automated software.  With the ability to perform high energy collisional-induced dissociation (CID), the instrument can provide highly informative MS/MS spectra for a variety of compounds including peptides, sugars, lipids, small molecules, etc. This instrument provides high sensitivity and resolution using the curved field reflectron for MS/MS without re-acceleration.

 

SCIEX X500R QTOF PLATFORM coupled to an EXION LC AC SYSTEM
Through an NIEHS supplemental grant to the University of Rhode Island (URI) STEEP Superfund Research Program (Rainer Lohmann, PI), the following instrument is available across URI for all researchers: 
A tandem (MS/MS) mass spectrometer combining a quadrupole and a time-of-flight analyzer allows collecting high-resolution MS and MRM spectra. The instrument is suitable for both quantitative analysis as well as non-targeted approach and operates under SCIEX OS software. The collected data are evaluated using an independent processing station (SCIEX Alpha Workstation 2020) equipped with SCIEX OS-Q software.
The instrument is located at: The Narragansett Bay Campus, Graduate School of Oceanography. Center for Atmospheric Chemistry Studies (CACS).
To reserve a time for the SCIEX X500R “only”, please email the following contacts:
Simon Vojta (vojta@uri.edu)
Thomas Garrow (thomas_garrow@uri.edu)